Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 110 children-between 0-16 years of age-, 90 children with Down-syndrome and 20 controls the following metabolic parameter were analyzed: ETK (vitamin-B1-activating coefficient), EGR (vitamin B2), P-5'-P, EGOT (vitamin B6), GOT, GPT, pH, K, Na, Ca, Cl, uric-acid (HS). Among some important correlations between the different parameters it could be demonstrated-for the first time to our knowledge-that in Mongoloids a disturbance of the vitamin-B1-metabolism exists, certified by the so-called transketolase-test.
Fortschr Med 1975 Sep 11
PMID:[Studies on the state of vitamins B1, B2 and B6 in Down's syndrome]. 12 24

The halogenated pyrimidine analogue 5-bromo-2-deoxycytidine (BCdR) was infused into BALB/C mice bearing EMT-6 tumors via either the intravenous or intra-arterial route. Hepatic dehalogenation of the drug was blocked by 5-diazouracil (DAZU) in order to ascertain its relative importance in the degradation of intravenously administered analogues. Increased radiosensitization was noted with higher intravenous pyrimidine concentrations, but DAZU blockage of dehalogenation had little effect. These studies show that following intravenous infusion, enough BCdR apparently bypasses the hepatic vessels to permit tumor radiosensitization despite dilution of the drug by the systemic circulation.
Radiology 1977 Sep
PMID:Comparison of intravenous and intra-arterial pyrimidine infusion as a means of radiosensitizing tumors in vivo. 88 82

Mechanisms of temperature regulation were assessed by measurements of oxygen consumption (VO2), body temperature (Rre = rectal, Tsk = skin), evaporative water loss (EWL), regional distribution of blood flow, and blood volume. Hamsters (Mesocricetus auratus) were acclimated to ambient temperatures of 34 or 22 degrees C. VO2 of 34 degrees C-exposed animals was reduced to 50% of that of controls at 22 degrees C, whereas EWL with heat exposure was almost double that of controls. Heat-acclimated animals had a slightly elevated Tre in comparison to 22 degrees C-acclimated animals, whereas there was a marked elevation in Tsk with heat exposure, in contrast to control animals at 22 degrees C. Blood flow distribution measurements indicated that with 34 degrees C exposure there was a decreased flow in liver, kidney, and intestine, whereas there was an increase to the carcass. Red cell and plasma volumes in heat-acclimated hamsters were decreased belwo the values of the 22 degrees C controls. Heat acclimation of the fhamster appears to involve reduced VO2 and increased WEL. Convective and radiative heat loss appear to be maintained by increased Tsk with heat exposure. Nonevaporative heat dissipation mechanisms are of primary importance in thermoregulation of the heat-acclimated hamster, and it is suggested that this is mediated by increased peripheral blood flow with reduced flow to the viscera.
Am J Physiol 1976 Sep
PMID:Mechanisms of temperature regulation in heat-acclimated hamsters. 97 Apr 52

A mathematical model has been developed to anticipate the physiological responses and the thermal state of a naked human under exposure to cold, taking into account his morphological characteristics (skinfold, size, weight) and the environmental conditions (air or water temperature and velocity, barometric pressure and hygrometry). The skinfold conditions the body's thermal conductance and the metabolism depends both on rectal (Tre) and mean skin (Tsk) temperatures. After being tested, this model was used to study the evolution of Tre. It shows the influence of the skinfold which accounts for most of the inter-individual differences. It also permits discussion of survival possibilities during immersion and completes data provided by previously established curves.
Aviat Space Environ Med 1976 Sep
PMID:Mathematical model of man's tolerance to cold using morphological factors. 97 Nov 75

Metabolic rate (M), mean skin temperature (Tsk) and rectal temperature (Tre) were studied during 2 h exposure to cold in the air (Ta = 15-25 degrees C) and in water (TH2O = 24-32 degrees C). From the results, it was possible to draw tentative equations of the metabolic response in transient and steady state as functions of body temperatures: Mair = 41,3-57.77 dTsk/dt-5.01 (Tskt-Tsk0) and Mwater = Mair + 984.15-23.79 Tre. These equations show an important difference between the two groups of experiments: in water, both Tsk and Tre are required, whereas Tsk suffices in air. This leads to discuss the usage of mean weighted skin temperature and rectal temperature to describe peripheral and central input respectively, specially on man in cold air, in the range of these experiments.
Pflugers Arch 1976 Sep 30
PMID:Comparison of shivering in man exposed to cold in water and in air. 98 64

This study concerns the antigenic competition among heterologous red cells, a T suppressor-dependent phenomenon, in three cases, when the two antigens are administered by various routes, in (a) splenectomized mice or in Nude mice reconstituted with (b) lymph node cells, or spleen cells. Competition occurs whatever the routes of antigenic introduction, except when the two antigens are injected subcutaneously in the same leg and the anti-SRC plaque-forming cells are counted in the draining lymph nodes. In that case, the first antigen plays the role of adjuvant to the second. An adjuvant effect is also observed in splenectomized mice when the antigens are introduced intraperitoneally. However, competition does not occur in Nude mice but is present when those animals have been reconstituted either with lymphnode cells or with spleen cells. Those results play in favor of the presence of T suppressors, both in lymph nodes and in spleen; however, in lymph nodes, the immunosuppressive action induced by the first antigen is exceeded by an concomitant adjuvant effect.
J Immunol 1975 Sep
PMID:Antigenic competition between two sequentially acting antigens. Immunosuppressive effect of T cells in spleen and lymph nodes of mouse. 109 23

A 22-week training program for EMT-A technicians, developed at the University of Connecticut Health Center, has been described. The program is coordinated by a trauma surgeon and a security officer, and teaching is carried out by faculty, residents, emergency-room nurses, experienced rescue-team members, EMT firemen, and the like. Lectures and videotaped practical problems are used. High levels of teaching and cooperation between the university health center and the community were maintained.
J Trauma 1975 Sep
PMID:Emergency medical technician (EMT-A) training in a medical school environment. 115 72

Seven lean and five obese boys, aged 9-12 yr, exercised in four environments: 21.1, 26.7, 29.4, and 32.2 degrees C Teff. Subjects walked on a treadmill at 4.8 km/h, 5% grade for three 20-min exercise bouts separated by 5-min rest periods. Rectal temperature (Tre), skin temperature (Tsk), heart rate (HR), sweat rate, and oxygen uptake (VO2) were measured periodically throughout the session. Lean boys had lower Tre and HR than obese boys in each of the environments. Increases in Tre were significantly greater for the obese at 26.7 and 29.4 degrees C Teff. No significant differences in Tsk and sweat rate (g-m-2-h-1) were observed between lean and obese boys. Obese boys had significantly lower oxygen consumptions per kg but worked at a significantly higher percentage of VO2max than lean boys when performing submaximal work. Responses of the obese boys to exercise in the heat were similar to those of heavy prepubertal girls studied previously, except that the boys were more tolerant of exercise at 32.2 degrees C Teff than the girls. Lean boys had lower HR than lean girls in each environment, but lower Tre only at 32.2 degrees C Teff.
J Appl Physiol 1975 Sep
PMID:Heat tolerance of exercising lean and obese prepubertal boys. 117 12

Preliminary studies of RAS mutational activation in human testicular germ cell neoplasms have yielded conflicting results. Whereas two studies of clinical material revealed a significant incidence of N- and KRAS mutations, two studies of a variety of germ cell lines failed to document RAS mutations. To clarify the incidence of RAS mutations in these tumors, we studied archival paraffin-embedded, formalin-fixed orchiectomy specimens from 25 nonseminomas (NSGCT), 18 seminomas (SEM), and one Leydig cell tumor. For 14 of the 44 neoplasms, DNA was also available from nonmalignant testis adjacent to the tumor. Six age-matched patients had testes removed because of nonmalignant disease and were studied as controls. Polymerase chain reaction (PCR) amplified the K-, N-, and HRAS 12, 13, and 61 codons of these specimens, and mutations were detected with mutation-specific oligonucleotide probe hybridization of Southern and slot blots. Four mutations were found in KRAS 12 (4/44;[9.1%]). One seminoma [1/18(5.6%)] contained the mutation GGT(GLY)----CGT(ARG), and three NSGCT [3/25(12%)] were found to have GGT(GLY)----GAT(ASP) mutations. One of the NSGCT mutations was detected in adjacent nonmalignant tissue, but the corresponding tumor did not contain any detectable mutation. No mutations were detected at KRAS 13 or 61, in NRAS or HRAS 12, 13, or 61, or in the control normal testes. PCR, slot blots, and hybridizations were performed twice by two separate investigators for confirmation of results. PCR-generated mutation-specific positive controls were created for all possible RAS mutations, and these along with wild-type DNA controls were integral to interpretation of the oligonucleotide mismatch hybridization assay. By using positive and negative controls, we have detected a relatively low incidence of RAS mutations in archival human testicular germ cell tumors.
Genes Chromosomes Cancer 1992 Sep
PMID:Detection of RAS mutations in archival testicular germ cell tumors by polymerase chain reaction and oligonucleotide hybridization. 138 46

Neuropeptide-stimulated tyrosine phosphorylation of specific components in Swiss 3T3 cells was investigated using monoclonal antibodies directed against the src transformation-associated substrates p125 focal adhesion kinase (FAK), a novel type of cytosolic tyrosine kinase, and p130. Treatment of Swiss 3T3 cells with the mitogenic peptides bombesin, vasopressin, and endothelin caused a striking increase in the tyrosine phosphorylation of p125FAK, as judged either by anti-phosphotyrosine (anti-Tyr(P)) Western blots of anti-p125FAK immunoprecipitates, or by anti-p125FAK immunoblots of anti-Tyr(P) immunoprecipitates. Bombesin-stimulated tyrosine phosphorylation of p125FAK was detectable within seconds and concentration-dependent (half-maximum effect of 0.3 nM). Neuropeptides also stimulated the tyrosine phosphorylation of a second component of M(r) 130,000, previously identified as the major p130 phosphotyrosyl protein in src-transformed cells. Bombesin stimulated p130 tyrosine phosphorylation with kinetics and concentration dependence similar to those observed for p125FAK. This is the first report to identify substrates for neuropeptide-stimulated tyrosine phosphorylation; the finding that one of these substrates is a tyrosine kinase suggests the existence of a novel signal transduction pathway in the action of mitogenic neuropeptides.
J Biol Chem 1992 Sep 25
PMID:Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate. 138 65


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