Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.10.2 (
focal adhesion kinase
)
44,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Focal adhesion kinase is a non-receptor, tyrosine kinase of cells whose key functions are cell adhesion, migration, and invasion. Aberrant expression and regulation of
FAK
-mediated intracellular signaling pathways has been reported in several cancers and they are involved in cancer cell migration and apoptosis resistance. By RT-PCR, we found that cervical cancer cells showed a 4-fold increase of relative mRNA expression of
FAK
compared to control cells. In parallel, the
FAK
protein expression level was also elevated in cervical cancer cells. Interestingly, knockdown of
FAK
in cervical cancer cells showed attenuated cell proliferation and migration. Further, the
FAK
RNAi cells became more sensitive to chemotherapeutic drugs such as
5-FU
and docetaxel and therefore the rate of cell survival is declined. The significant over-expression of
FAK
in cervical cancer cells might involve in cervical carcinogenesis and prolonged cell survival. This
FAK
overexpression might be a potential target for anti-cancer drugs to attenuate rapid cell proliferation and invasion by inducing apoptosis.
...
PMID:Clinical significance of focal adhesion kinase (FAK) in cervical cancer progression and metastasis. 3316 33
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