Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.10.2 (
focal adhesion kinase
)
44,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Gemcitabine is widely used as an anticancer chemotherapy drug for a variety of solid tumors, and it has become the standard treatment option for locally advanced and metastatic pancreatic cancer. However, pancreatic cancer cells develop resistance to gemcitabine after a few weeks of treatment, resulting in poor therapeutic effects.
Isocorydine
(
ICD
) is a typical natural aporphine alkaloid, and
ICD
and its derivatives inhibit the proliferation of many types of cancer cells in vitro. In this study,
ICD
was found to synergistically inhibit cell viability with gemcitabine in pancreatic cancer cells. A microarray analysis showed that
ICD
can inhibit the upregulation of STAT3 and
EMT
in pancreatic cancer cells induced by gemcitabine. STAT3 is closely related to tumor
EMT
, migration and invasion. After knocking down the expression of STAT3 in pancreatic cancer cells, the combination index (CI) of
ICD
and gemcitabine decreased.
ICD
can reverse the increase in the expression of
EMT
-related transcription factors and proteins caused by gemcitabine, thereby inhibiting the enhanced cell migration and invasion ability caused by gemcitabine. Finally, the synergistic treatment effect of the combination treatment of
ICD
and gemcitabine in pancreatic cancer cells was confirmed in established xenograft models.
...
PMID:Isocorydine decrease gemcitabine-resistance by inhibiting epithelial-mesenchymal transition via STAT3 in pancreatic cancer cells. 3277 28
