Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Infections of the cervix with Chlamydia trachomatis are common, at least in those groups of sexually active women of child-bearing age who are seen in STD (sexually-transmitted diseases) clinics. Persistent untreated infection presents a hazard to the women themselves during pregnancy and to their infants who may develop chlamydial conjunctivitis. The clinical and laboratory findings in 1009 women and in 103 infants with conjunctivitis are presented. Practical problems of diagnosis and control of neonatal chlaymdial conjunctivitis are described. A possible association between prematurity and chlamydial infection is discussed.
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PMID:Maternal genital chlamydial infection as a cause of neonatal conjunctivitis. 59 78

One hundred thousand (100,000) people are living--thanks to Artificial Kidneys. We need more emphasis on Home Dialysis. The immediate future will bring us: WAK (Wearable Artificial Kidney) FAK (Filtrating Artificial Kidney) PAK (Peritoneal Artificial Kidney) HAK (Hemoperfusion Artificial Kidney). Intra-aortic balloon pumps and transapical left ventricular bypass may offer patients now dying from heart failure, a possibility to either recover or be maintained until an artificial heart is available. Our aim is to create an Artificial Heart to totally replace the irreparably sick human heart. We have obtained survival times up to more than six months after total replacement of the natural heart in calves. Dr. Steve Jacobsen's Artificial Arm is activated by electromyographic signals that are derived from the shoulder muscles. The Artificial Eye makes use of direct stimulation of the visual cortex of the brain by arrays of electrodes situated against the visual cortex. For the Artificial Ear, we stimulate the fibers of the eighth nerve by threading platinum wires up into the cochlea. Deaf volunteers can hear rhythm, loudness and some pitch.
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PMID:Exponential growth and future of artificial organs. 61 76

In the Harleco Micro CO2 System a volumetric procedure is used to measure total CO2 content in a small volume (0.10 ml) of serum or plasma. CO2 gas is released by mixing specimen and acid, either manually or with a "Micro CO2 Shaker." Within-batch CV's by manual and machine shakings were, respectively, 7.7 and 5.6% for a total CO2 value of 8 mmol/liter, decreasing to 2.0 and 1.4% for a value of 45 mmol/liter. Between-batch CV's were 8.0 and 7.1% at low total CO2, decreasing to 2.4 and 2.0% at high total CO2. Measurements were linear for values from 5 to 60 mmol/liter. Analytical recoveries at low and high concentrations were 97.7 to 98.9%. Correlation coefficients for results obtained with the Technicon "SMA Plus" autoAnalyzer and the Radiometer ABL 1 blood gas analyzer were 0.992 and 0.996, respectively. The Harleco Micro CO2 System appears to be a quick, reliable, and inexpensive method for measuring serum or plasma total CO2.
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PMID:Evaluation of the Harleco Micro CO2 system for measurement of total CO2 in serum or plasma. 61 44

The Lagergren cage electrode Elema EMT 588 K was implanted in 26 male and 21 female patients for permanent cardiac stimulation. 29 of the 47 cage electrodes were fitted with a platinum and 18 with an Elgiloy head. Acute threshold in the platinum group was 0,52 +/- 0,15 volts (x +/- s), the equivalent electrode resistance being 565 +/- 135 ohms. The threshold mean value for the Elgiloy cage electrodes was shown to be 0,36 +/- 0,11 volts, while the resistance values measured respectively 410 +/- 44 and 418 +/- 23 ohms depending on the method of measurement. In the postoperative period (up to 16 months) the following complications were observed: 3 dislocations (6,38%) and one case of rise in threshold (2,12%). The total correction rate (8,5%) corresponds almost exactly to that recorded by the author in a personal series of 400 electrode implantations of various designs. The cage electrode offers no advantages in comparison to other small surface electrodes, however, the relatively higher current consumption caused by low total electrode resistance must be regarded as disadvantages. Experience with the cage electrode has shown that the transitional resistance depends not only on the surface, but also essentially on the material and shape of the electrode tip.
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PMID:[Clinical experience with the cage electrode EMT 588 K. Threshold--current consumption--postoperative complications (author's transl)]. 62 19

The response to local cooling was estimated by the cold hand test (5 degrees C for 2 min) and the cold face test (0 degrees C with 66 km.h-1 wind for 2 min). Heart rate, blood pressure, and skin temperature were measured before, during, and after the tests. The increase in blood pressure (cold hand test) and the fall in Tsk (cold face test) were reduced in trained subjects. Similarly older subjects (53-60 yr of age) responded less to a cold hand test than younger subjects aged 20-40. However, the bradycardia caused by the cold face test was more pronounced in the older subjects. The responses to the cold hand and cold face tests were the same for male and female subjects. During the 2 min after the test, blood pressure and heart rate fell below initial values in the female group but not in the male. It is concluded that, besides adaptation to cold, individual factors such as age, sex, and physical fitness also have a relative importance in the responses to local cooling.
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PMID:Effects of age, sex, and physical fitness on responses to local cooling. 64 81

A study has been conducted on 20 sojourners (SJs) at a high altitude (HA) of 3500 m to evaluate the changes in thermoregulation efficiency (ThE) during acclimatization for 3 weeks, by observing the rate and pattern of rewarming of palm skin temperature (Tsk) after dipping the hand in water of 10 +/- 1 degrees C for 2 min (Tromp's water bath test). The ThE of the SJs was compared to that of 10 acclimatized lowlanders (ALs) staying at the same altitude for about 1 year and 10 high-altitude natives (HANs). In SJ, at sea level (SL), the effect of seasonal variation and ambient temperature on ThE was also studied. The initial Tsk of the palm (29.9 degrees C) was lower at altitude as compared to SL value (32.2 degrees C) in SJs inspite of similar ambient temperature (21 +/- 1 degrees C). There was a prolongation of rewarming time in all the subjects during stay at altitude. The rewarming curve showed a shift towards the right, indicating slower rewarming. The rewarming response of ALs and SJs was comparable at altitude. In HANs, the rewarming at altitude was faster and resembled those of SJs at SL. The rewarming improved in the season following cold months, and at higher ambient temperature in the same season, on the plains. It may be concluded that thermoregulation efficiency of man deteriorates at high altitude, and the peripheral vascular responses to local cold stress do not reach the level attained by natives even after 1 year of acclimatization. General cold acclimatization improves the rewarming response.
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PMID:Effect of altitude acclimatization on thermoregulation efficiency of man. 65 93

Effective prehospital treatment of the severely injured and acutely ill by an Advanced Emergency Care system may change symptoms and signs by the time patients arrive at the hospital. To provide optimal care, physicians must appreciate the capabilities and limitations of the EMT-paramedic. The EMT-paramedic must report verbally and via written record the course of prehospital events. Cardiac rhythms must be documented for review. It should be the responsibility of the medical directors of such Advanced Emergency Care systems to provide supervision, refresher training, critiques, and evaluation, to establish medical responsibility and credibility.
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PMID:Prehospital advanced emergency care: a potential pitfall. 66 Jun 82

62 cases of ABL have been investigated over the last 20 years. In our series ABL were 5% of all acute leukaemias. Four ABL types can be distinguished : (a) the basophilic terminal phase (basophilic blastic crisis) of cronic myeloid leukemia; (b) the mixed basophilic-oesinophilic types; (c) the promyelocytic basophilic type; and (d) histio basoblastic type. The first two are quite rare. The promyelocytic basophilic type can be easily differentiated from PNL; the frequency of the latter is three times higher. Fundamental to diagnosis are cytochemical stains specific for acid mucopolysacchaes. Myelobiopsy is always essential since in almost 50% of the cases no typical cells appears in the peripheral blood. In the bone marrow Ab are very numerous and and pleiomorphic. ABL is marked from its onset by a severe symptomatology. In contrast to our experience in PNL, only do some patients with ABL achieve complete remission.
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PMID:Follow-up of sixty two cases of acute basophilic leukemia. 66 77

The effect of varying humidity and dry bulb temperatures was studied on five normal male unclothed subjects while exercising (40-45 min) at 28% VO2max. Air movement was 0.75 m.s-1. The initial test and the 16th test on each subject both done at 50 degrees C and 30 Torr (32% rh). Each subject did the intervening 14 experiments twice per day at varying ambient temperature (Ta) and water vapor pressure (Pa) levels, so selected to progressively increase skin wettedness levels. Mean skin temperature (Tsk) and esophageal temperature (Tes), heart rate (HR), skin evaporative heat loss (Esk), and warm discomfort were continuously observed. Skin wettedness (w) was evaluated as the ratio of the observed Esk to the maximum evaporative capacity of the environment. A rational effective temperature (ET) is defined as the dry bulb temperature at 50% rh in which the total heat exchange from skin surface would be the same as in the test environment, described by the observed Ta and Pa. The results showed that 1) during steady state both HR and Tes were unaffected by Ta from 26 to 41 degrees C responding to the level of exercise intensity, when Pa less than or equal to 20 Torr; 2) both mean body temperature, found by weighting Tsk:Tes by 1:9, and ET were each significant indicators of physiological strain when Pa greater than 20 Torr; 3) a level of strain, caused by skin wettedness values greater than 0.5, is suggested as a primary condition necessary for inducing heat acclimation.
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PMID:Indices of thermoregulatory strain for moderate exercise in the heat. 67 11

Heat-acclimated, lightly clothed men and women (four of each) walked on a treadmill at 25% and 43% VO2 max, respectively, (M =194 W.m-2), under seven air temperatures (Ta) ranging from 36 to 52 degrees C. Each experiment involved 1 h of fixed and a 2nd h of progressively increasing ambient vapor pressure (Pa). The relative steady state of rectal temperature (Tre), mean skin temperature (Tsk), and heart rate (HR) reached in the 1st h were forced upward during the 2nd h by the rising Pa. The critical air vapor pressure (Pcrit) was identified by the Tre point of inflection for each Ta. One man did not fully reach steady state, but inflection could be determined for his physiological responses. The mean values of all points of inflection were calculated for Tre, Tsk, and HR. Significant sex difference in HR was found only by excluding the results of the one man. Tre and Tsk showed no significant difference between men and women. The coefficient for evaporative heat transfer (he), which could be derived using the Pcrit for the low Ta range, was 14.5 +/- 2.2 W.m-1 Torr-1.
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PMID:Physiological and biophysical limits to work in the heat for clothed men and women. 67 12


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