Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This article describes the efforts of local Philippine HIV/AIDS programs to widen their reach and sustain their efforts. The model assumes that the engagement of an ever larger number of institutions that understand HIV/AIDS issues and are committed to prevention and care will help foster safer sexual behavior. The Philippines HIV/AIDS Nongovernmental Organization (NGO) Support Program (PHANSuP), with the support of the International HIV/AIDS Alliance, developed skills and strategies workshop sessions. This pilot training program builds and strengthens local NGO capacity and partnerships between sectors. The Alliance in 1993 raised funds for PHANSuP, and PHANSuP supported local NGOs, including the Olangapo City AIDS Foundation (OCAFI). OCAFI was forced to stretch the new funding over a longer period and agreed to be a resource for a wide variety of local institutions rather than a single AIDS project. In this way, resources were complementary and more broadly distributed. OCAFI built partnerships with a variety of institutions ranging from the local Rotary Club to the casino. The result was wider financial, political, and practical support in Olangapo City, and improved access to vulnerable groups. The pilot program proved that local NGOs could reduce their dependency on PHANSuP financial support. The links between NGOs and government health services have led to a wider reach of the education programs and the use of mass media. PHANSuP has developed several initiatives to promote the view that partnerships between different sectors are possible and that sustainability is possible. Programs must sell themselves to the local community, which in turn will support the programs.
AIDS STD Health Promot Exch 1997
PMID:Country watch: The Philippines. 1229 22

The National Alliance of State and Territorial AIDS Directors and the National Coalition of STD Directors have published a report on STD/HIV integration that provides reasons for integration as well as steps that state and local jurisdictions can take to support integration. For instance, recent studies have demonstrated that being infected with an STD may take it 2 to 23 times easier to transmit HIV, depending on the specific STD.
 ...
PMID:Taking steps toward STD/HIV integration. 1271 35

The National Alliance for Medical Image Computing (NA-MIC) was launched in 2004 with the goal of investigating and developing an open source software infrastructure for the extraction of information and knowledge from medical images using computational methods. Several leading research and engineering groups participated in this effort that was funded by the US National Institutes of Health through a variety of infrastructure grants. This effort transformed 3D Slicer from an internal, Boston-based, academic research software application into a professionally maintained, robust, open source platform with an international leadership and developer and user communities. Critical improvements to the widely used underlying open source libraries and tools-VTK, ITK, CMake, CDash, DCMTK-were an additional consequence of this effort. This project has contributed to close to a thousand peer-reviewed publications and a growing portfolio of US and international funded efforts expanding the use of these tools in new medical computing applications every year. In this editorial, we discuss what we believe are gaps in the way medical image computing is pursued today; how a well-executed research platform can enable discovery, innovation and reproducible science ("Open Science"); and how our quest to build such a software platform has evolved into a productive and rewarding social engineering exercise in building an open-access community with a shared vision.
 ...
PMID:Increasing the impact of medical image computing using community-based open-access hackathons: The NA-MIC and 3D Slicer experience. 2749 15

Osteosarcoma (OS) is a primary malignant bone neoplasm with high frequencies of tumor metastasis and recurrence. Although the Akt/PKB signaling pathway is known to play key roles in tumorigenesis, the roles of cyclin-dependent kinase-like 3 (CDKL3) in OS progression remain largely elusive. We have demonstrated the high expression levels of CDKL3 in OS human specimens and comprehensively investigated the role of CDKL3 in promoting OS progression both in vitro and in vivo. We found that CDKL3 regulates Akt activation and its downstream effects, including cell growth and autophagy. The up-regulation of CDKL3 in OS specimens appeared to be associated with Akt activation and shorter overall patient survival (P = 0.003). Our findings identify CDKL3 as a critical regulator that stimulates OS progression by enhancing Akt activation. CDKL3 represents both a biomarker for OS prognosis, and a potential therapeutic target in precision medicine by targeting CDKL3 to treat Akt hyper-activated OS.
Life Sci Alliance 2020 05
PMID:CDKL3 promotes osteosarcoma progression by activating Akt/PKB. 3223 50