Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Continuing evolution in cardiac stimulation today imposes on PM manufacturers the need to submit their products under new criteria, such as: contained dimensions, functional complexity and longer periods of patient care. PM electronic circuity plays a determinant role in meeting the best solution of these problems. Thick film hybrid technology has been chosen by the Authors because it is deemed to be the best compromise for the present goals, such as: low power consumption, low weight and small size, electrical parameters stability, functional complexity and high circuitry density, Hi-Rel performance for longer working life. A little space has been reserved for schematic diagrams of the manufacturing cycle and the applied technology; particular evidence has been shown concerning selection criteria for circuitry component selection and Hi-Rel tests for the end product. Hi-Rel and qualification standards have been selected by the Authors from MIL-STD 883 methods and AAMI-FDA pacemakers standards. Practical results of the application of this methodology can be summarised as follows: only 44-50% of the total circuits pass the complete cycle of tests and thus are used for PM manufacture; electronic failure rate in the implanted units is 0.024% failure per month.
 ...
PMID:[Technology and real performances of a new circuit for new pacemaker (author's transl)]. 75 62

In 1983 the U.S. Army Academy of Health Sciences developed a Letter Requirement for a Blood Gas/pH Analyzer for use in Echelon 3 and 4 facilities. Field trials of several nondevelopment items and a subsequent market survey did not produce a suitable instrument. Recently, a relatively small, lightweight, and simple device became commercially available, and was tested for field applicability in accordance with MIL-STD-810D. Results indicated that with minor modifications, the instrument would be sufficiently rugged to withstand the severe storage temperature extremes and transit shock and vibration conditions associated with deployment of field medical materiel.
 ...
PMID:Environmental testing of a blood gas/pH and electrolyte analyzer for field hospital use. 212 51

This article describes basic sampling principles and the application of statistical sampling techniques to specific problems encountered in the Food and Drug Administration (FDA). Concepts are emphasized, and theory is minimized. The basic principles of sampling from a normal and binomial population, including confidence interval calculation and sample size determination, are briefly reviewed. Stratified, random, systematic, and judgment sampling are explained. Operating characteristic curves for attribute (and perhaps variable) sampling for acceptance of lots are derived and applied to specific FDA problems. The advantages and disadvantages of single and multiple sampling plans and plans which address multiple classes of criteria such as major and minor defects are discussed. Sampling schedules such as MIL-STD-105D and Canada's Government Specifications Board CGSB-105-GP-1 are reviewed to familiarize readers with the principles involved in these plans and to give them an idea of how they could be applied to FDA problems.
 ...
PMID:Statistical sampling approaches. 338 77

Inspection by variables is proposed as an acceptance criterion for use in bioanalysis. The criteria currently used are deficient either by ignoring the issues of precision (fixed range) and/or accuracy (99% confidence interval), not being able to provide immediate answers (quality charts), or even not being scientifically justified (fixed range). Inspection (sampling) by a variables procedure was originally developed to drive the quality of military supplies (MIL-STD-414) and was consequently incorporated in ISO 3951 as a part of industrial quality control. It is based on the concept of acceptable quality level (AQL), which is the maximum per cent defective (number of results outside of specification per 100 results) that can be considered satisfactory as a process average. It also correlates sample size with batch size. An AQL of 6.50% is proposed as a standard with specification set at +/- 20% or +/- 15%, which should result in coefficients of variation of approximately 15% and 12%, respectively. This concept has been applied post factum to 14 authentic data sets, thus proving its utility and validity.
 ...
PMID:Inspection by variables as an acceptance criterion in bioanalysis--a proposal. 878 25

When used in an air medical setting, medical equipment designed for use in hospitals can fail from the stresses of in-flight use, or they interfere with critical rotor-wing aircraft systems. From January 1989 to June 1992, 34 medical devices, including monitor/defibrillators, infusion pumps, vital-signs monitors, ventilators and infant transport incubators, were tested under extreme conditions of temperature, humidity, altitude and vibration (MIL-STD 810D). Electromagnetic emissions and susceptibility were measured (MIL-STD 461C and 462), and human factors were evaluated. The devices were flight tested in a UH-60 MEDEVAC helicopter. Thirty-two percent of the medical devices failed at least one environmental test, and 91% of the devices failed to meet electromagnetic interference standards. Failures included excess conducted and radiated emissions and susceptibility to radiated emissions. Five (15%) of the devices were judged unsuitable for use in the UH-60 MEDEVAC helicopter. Testing is critical to discover the ability of a medical device to perform in the harsh rotor-wing MEDEVAC environment. Failure of a device or interference with aircraft systems can result in loss of a patient or aircrew.
 ...
PMID:Laboratory and flight tests of medical equipment for use in U.S. Army Medevac helicopters. 1012 60

Several microbes were isolated from the contaminated fuel-oil in Taiwan and the microbial corrosion of aluminum alloy A356-T6 was tested by MIL-STD-810E test method. Penicillium sp. AM-F5 and Cladosporium resinac ATCC 22712 had significant adsorption and pitting on the surface of aluminum alloy, Pseudomonas acruginosa AM-B5 had weak adsorption and some precipitation in the bottom, and Candida sp. AM-Y1 had the less adsorption and few cavities formation on the surface. pH of the aqueous phase decreased 0.3 to 0.7 unit for 4 months of incubation. The corrosion of aluminum alloy was very significant in the cultures of Penicillium sp. AM-F2, Penicillium sp. AM-F5 and C. resinac ATCC 22712. The major metabolites in the aqueous phase with the inoculation of C. resinac were citric acid and oxalic acid, while succinic acid and fumaric acid were the minors.
 ...
PMID:Microbial corrosion of aluminum alloy. 1059 1

Four impulse noise auditory injury criteria adopted by NATO countries, namely, the MIL-STD-1474D (USA), Pfander (Germany), Smoorenburg (Netherlands), and L(Aeq8) (France), are evaluated against human volunteer data. Data from subjects wearing single-hearing protection exposed to increasing blast overpressure effects were obtained from tests sponsored by the US Army Medical Research and Material Command. Using logistic regression, the four criteria were each correlated with the test data. The analysis shows that all four criteria are overly conservative by 9.6-21.2 dB for the subjects as tested. The MIL-STD-1474D for single-hearing protection is 9.6 dB lower than the observed injury threshold for 95% protection with 95% confidence for this particular group of subjects as tested. Similar conclusions can be drawn for the other three criteria.
 ...
PMID:Evaluation of impulse noise criteria using human volunteer data. 1168 77

This paper provides a discussion of several standards and guidelines for design of visual display terminal (VDT) workplaces. The material represents products of government agencies, commercial standards organisations and of labour unions. Seven documents are reviewed: US MIL STD 1472-C, German DIN 66234, British HSE, Swedish ISO Proposal, British APEX, US NYCOSH, and Australian ACTU-VTHC. There is considerable disagreement in the specification of design parameters in these standards. The issues are discussed in terms of their importance and the availability of supporting ergonomics research. There are several types of VDT tasks and the number and variety of applications are growing rapidly. Due to these factors and the development of new display technologies, different recommendations may be appropriate depending upon the task and the technology. Research and careful deliberation will be required to deal with this development.
 ...
PMID:An overview of standards and guidelines for visual display terminals. 1567 18

Tabled sampling schemes such as MIL-STD-105D offer limited flexibility to quality control engineers in designing sampling plans to meet specific needs. We describe a closed form solution to determine the AQL indexed single sampling plan using an artificial neural network (ANN). To determine the sample size and the acceptance number, feed-forward neural networks with sigmoid neural function are trained by a back propagation algorithm for normal, tightened, and reduced inspections. From these trained ANNs, the relevant weight and bias values are obtained. The closed form solutions to determine the sampling plans are obtained using these values. Numerical examples are provided for using these closed form solutions to determine sampling plans for normal, tightened, and reduced inspections. The proposed method does not involve table look-ups or complex calculations. Sampling plan can be determined by using this method, for any required acceptable quality level and lot size. Suggestions are provided to duplicate this idea for applying to other standard sampling table schemes.
 ...
PMID:Determination of closed form solution for acceptance sampling using ANN. 1581 95

Predicting auditory hazard from intense acoustic impulses, such as weapons fire or airbags, has been an intractable problem. The U.S. Army developed a theoretically based mathematical model of the ear designed to predict such hazards [the Auditory Hazard Assessment Algorithm for the Human (AHAAH)]. To validate it as a predictor of hazard, data from the literature (wave forms and changes in hearing sensitivity) were processed with the model in order to predict the onset of unacceptable threshold shift (25 dB or more) in the 95th percentile human ear. For comparison, alternate standards MIL-STD-1747D and A-weighted energy were also used to compute hazards for the same data. The primary dataset was that of the US Army's "Albuquerque studies" (53 different cases) and other impulses from the literature (19 additional predictions). The AHAAH model predicted correctly in over 95% of the cases, the MIL-STD-1474D was correct in 42% of the cases, and A-weighted energy was correct in 25% of the cases. Errors for all methods tended to be in the direction of overprediction of hazard. In addition to greatly increased accuracy, the AHAAH model also has the advantage of being theoretically based and including novel diagnostic features.
 ...
PMID:Validation of the auditory hazard assessment algorithm for the human with impulse noise data. 1818 69


1 2 3 Next >>