Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Here, we examine the currently available information which supports that the adipokine, leptin, is a major player in the biology and pathology of mammalian skin and its appendages. Specifically, the potent metabolic effects of leptin and its mimetics may be utilized to improve, preserve and restore skin regeneration and hair cycle progression, and may halt or even partially reverse some aspects of skin ageing. Since leptin can enhance mitochondrial activity and biogenesis, this may contribute to the wound healing-promoting and hair growth-modulatory effects of leptin. Leptin dependent intracellular signalling by the Janus kinase 2 dependent signal transducer and activator of transcription 3, adenosine monophosphate kinase, and peroxisome proliferator-activated receptor (PPAR) gamma coactivator/PPAR converges to mediate mitochondrial metabolic activation and enhanced cell proliferation which may orchestrate the potent developmental, trophic and protective effects of leptin. Since leptin and leptin mimetics have already been clinically tested, investigative dermatology is well-advised to place greater emphasis on the systematic exploration of the cutaneous dimensions and dermatological potential of this pleiotropic hormone.
Exp Dermatol 2010 Jan
PMID:Leptin and the skin: a new frontier. 1960 81

Since 2000, the incidence of syphilis has risen in developed countries. An updated knowledge of syphilis features is the key for early diagnosis and treatment. Our objective was to appraise the clinical and epidemiological presentation of syphilis in Paris, France. A retrospective monocentric descriptive study of 284 consecutive syphilis cases was conducted in a venereal disease centre (Paris, France), over the period 2000-2007. Epidemiological, clinical and microbiological data were systematically collected, using standardized medical forms. Overall, 95% of the cases occurred in men (271/284), 83% in men having sex with men (MSM) (231/278), 58% in patients having more than 10 partners/year (138/240) and 19% in patients who never use a condom (49/253). At least one STD has been previously diagnosed in 79% (220/279) of the cases. In 50.5% of the cases (142/281), HIV serology was positive. Most patients had primary (82/279, 29%) or secondary (125/279, 45%) syphilis. The most frequent physical signs in primary and secondary syphilis were, respectively, a genital chancre (63/82, 77%) and a diffuse exanthema (108/125, 86%). Syphilis occurs chiefly in MSM, often in HIV-positive patients. Many patients never use condoms. These data will help provide the basis for the development of national information and screening campaigns.
Eur J Dermatol
PMID:The epidemiological and clinical presentation of syphilis in a venereal disease centre in Paris, France. A cohort study of 284 consecutive cases over the period 2000-2007. 1970 2

IFN-alpha and skin-infiltrating activated T lymphocytes have important roles in the pathogenesis of psoriasis. T cells from psoriatic patients display an increased sensitivity to IFN-alpha, but the pathological mechanisms behind the hyperresponsiveness to IFN-alpha remained unknown. In this study, we show that psoriatic T cells display deficient expression of the suppressor of cytokine signaling (SOCS)3 in response to IFN-alpha and a low baseline expression of the SH2-domain-containing protein-tyrosine phosphatase (SHP)-1 when compared with skin T cells from nonpsoriatic donors. Moreover, IFN-alpha-stimulated psoriatic T cells show enhanced activation of JAKs (JAK1 and TYK2) and signal transducers and activators of transcription. Increased expression of SOCS3 proteins resulting from proteasomal blockade partially inhibits IFN-alpha response. Similarly, forced expression of SOCS3 and SHP-1 inhibits IFN-alpha signaling in psoriatic T cells. In conclusion, our data suggest that loss of regulatory control is involved in the aberrant hypersensitivity of psoriatic T cells to IFN-alpha.
J Invest Dermatol 2010 Jun
PMID:Deficient SOCS3 and SHP-1 expression in psoriatic T cells. 2013 May 95

A retrospective data analysis of one thousand STD patients from 1994 to 1998 at Medical College, Trivandrum was carried out. Males constituted 61.1% and females 38.9% in the study. Most of the STD patients were married (68%). In this group, 44.9% of males and 15% of females had extra marital contact (EMC). Of the 155 male married patients who had EMC, 128 (82%) had history of pre marital contact (PMC) as well. Commercial sex workers (CSWs) were the partners for most of the patients for EMC and PMC. The commonest STD was syphilis, both in men and women followed by herpes genitalis and condylomata acuminata. Latent syphilis was the most common type (54%) followed by sec- ondary. The prevalence of herpes genitalis and condylomata acuminata showed an increase with a def i-nite decline in the prevalence of gonorrhoea. HIV was detected in 3.2% of the patients.
Indian J Dermatol Venereol Leprol
PMID:An epidemiological study of sexually transmitted diseases. 2087 30

The study was done to determine the sexual risk behaviour and to monitor HIV seroprevalence among STD patients attending a STD clinic as a part of sentinel surveillance programme in North Eastern State of India. Face to face interviews, clinical and epidemiological investigations were carried out in all new patients. The frequency of condom use, and the number of sexual partners during the preceding 6 months were recorded. Out of 680 males, majority (66.4%) were aged 20-29 years. 89.2% men reported to have had sexual contacts with prostitutes. Being younger, single and staying away from home were independent risk factors for having sexual contact. 34.7% men used condom at all times, 27.2% reported inconsistent use and 38.1% did not use condoms. Eleven (1.6%) of the 680 STD patients tested were found to be HIV positive, did not use condom and had genitoulcerative disease.
Indian J Dermatol Venereol Leprol
PMID:Sexual behaviour and HIV prevalence in patients with sexually transmitted disease attending an STD clinic in north eastern state of India. 2092 50

Two hundred patients comprising of 144 males and 56 females ranging in age from 10 years to 68 years were studied. The incidence of HIV positive cases in STD patients was 13.5%. Maximum incidence of STD cases were seen in the age group between 21-25 years (27%). Maximum incidence of HIV seropositivity was seen in 19 and 20 years age group (33.8%). In HIV positive cases, there was a male predominance (62.9%). Most of the patients were from low socio-economic status, CSW were the common source and GUD was the most common STD association.
Indian J Dermatol Venereol Leprol
PMID:Incidence of HIV seropositivity in STD cases. 2092 61

The present study is based on 350 women having sexually transmitted diseases and 68 men counterparts. Trichomonas vaginalis was a significant contributor in 216 (61.7%) out of 350 female SID cases' and in 56 (82.3%) out of 68 male counterparts. Further, out of 216 cases of T.vaginalis, 41 cases (32.5%) were associated with infection with Candida species; 29 (23%) with Neisseria gonorrhoea. 18 cases (14.3%) with Haemophilus ducreyi and 11 cases (8.7%), Chlamydia trachomatis. Treponema pallidum was observed in 8 cases (6.3%) which constituted a low percentage. Present study highlighted the importance of T. vaginalis by showing positivity in two-third cases which suggested that it can be an important indicator for other etiological STD agents in women.
Indian J Dermatol Venereol Leprol
PMID:Trichomonas vaginalis - an indicator for other sexually transmitted infecting agents. 2092 95

A retrospective data analysis was carried out to find the trends in frequency and distribution of different STDs at Chengalpattu during 1988-1994. Of the 4549 patients who attended the clinic 3621 (79.6%) were males and 928 (20.4%) were females. The commonest STD was Chancroid (24.4%) in men and Syphillis (29%) in women. Balanoposthitis (11.4%) ranked third among STDs in males. Though the STD attendance showed a declining trend, most diseases showed a constant distribution. The percentage composition of secondary and latent syphillis, Genital Warts, Genital Herpes and the Non-Venereal group showed an increased composition in recent years. Primary syphillis in females showed a definite declining trend. The HIV sero-positive detection rate was 2.06%. Of the 1116 patients screened for HIV antibody, 23 patients were detected sero-positive. Time Series Regression Analysis was used to predict the number of patients who would attend the STD clinic with various STDs in 1995 and 1996 to help in the understanding of the disease load and pattern in future, in resources management and in developing and evaluating preventive measures.
Indian J Dermatol Venereol Leprol
PMID:Std trends in chengalpattu hospital. 2094 55

HBsAg was studied in 50 patients of STD's and promiscuous persons. In 10.52% cases it was positive. Vaccination against Hepatitis-B was recommended in promiscuous individuals.
Indian J Dermatol Venereol Leprol
PMID:HBsAg and sexually transmitted diseases. 2094 89

Sixty cases of cutaneous vasculitis were selected from department of Skin and STD, Government Medical College/Rajendra Hospital, Patiala. Detailed history, general physical examination, systemic examination and dermatological examination were conducted in each and every case. Routine investigations were done. Clinical diagnosis was confirmed by biopsy. Histopathologic study was conducted by using H & E stain under 100X and 400X by light microscopy.
Indian J Dermatol Venereol Leprol
PMID:Histopathological study of 60 cases of cutaneous vasculitis. 2094 19


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