Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Primary syphilis is characterized by a solitary, painless, indurated ulcer (chancre) at the site of inoculation, with associated inguinal lymph nodes that are enlarged, rubbery, painless and discrete. We report a case of syphilis that presented with penile swelling associated with tender lymphadenopathy and review the literature concerning this unusual presentation of early syphilis.
Int J STD AIDS 2008 Sep
PMID:Unilateral penile swelling: an unusual presentation of primary syphilis? 1872 59

A 27-year-old man who has sex with men presented with a painful lesion at the urethral meatus. A diagnosis of genital herpes was suspected, and initial tests for sexually transmitted infections (STIs), including syphilis serology, were negative. However, a polymerase chain reaction (PCR) swab for Treponema pallidum from the lesion was positive, and a diagnosis of chancre of primary syphilis at the meatus was made. Subsequently, the patient required urological surgery due to the formation of a urethral stricture. Chancre at the meatus and development of stricture are unusual complications of syphilis that may become more common in the future with increasing case numbers. We also discuss the development of PCR as a useful test for early primary syphilis.
Int J STD AIDS 2011 Sep
PMID:Primary syphilis of the urethral meatus complicated by urethral stricture. 2189 May 54