Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Objective: The attachment theory has been conceptualized as an affect regulation theory, proposing that attachment is associated with the expression and recognition of emotions as well as interpersonal functioning. The purpose of the study was to examine a model, in which a relation was analyzed between childhood trauma, temperament, alexithymia, and dissociation in a group of individuals addicted to alcohol. Method: The total number of 201 persons were examined, comprising 67 women (33.3% of participants) and 134 men (66.7% of participants). The participants aged from 18 to 68 (M = 32.81; SD = 12.12). In order to measure the analyzed variables, the following questionnaires were applied: MAST, SSSV, TAS20, TEC, and CES. Results: A comparative analysis between the group of alcohol addicts and non-addicts showed statistically significant differences related to: the intensity of trauma, temperament, alexithymia, and dissociation. The study of models related to the impact of traumatic experience intensity on the level of alcohol addiction with regard to a mediatory role of alexithymia, dissociation, and temperament showed the existence of several important indirect effects, and the model, which takes into account all three mediators, is statistically significant F(4,196) = 35.1964; p < 0.001. Conclusion: Childhood trauma, as well as alexithymia and dissociation block dealing with stress based on self-reflection and self-control, and contribute to affective disorders and their regulation with alcohol. Limitations: The selection of participants to homogeneous groups with regard to age and gender constituted the most important difficulty and limitation. A perfect age criterion for investigating the interaction between the temperament and the consequences of traumatic development would be early adulthood.
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PMID:Trauma, Temperament, Alexithymia, and Dissociation Among Persons Addicted to Alcohol: Mediation Model of Dependencies. 3024 52

While social cognition (SC) is widely recognized as being impaired in schizophrenia, little is known about the potential heterogeneity in individuals' functioning. Using a wide range of SC measures and a cluster-analytic approach, we compared SC profiles in the general population and in people with schizophrenia. A total of 131 healthy controls and 101 participants with schizophrenia were included. Groups were compared on sociodemographic, neurocognition, anxiety and depressive mood variables. Three profiles were identified in healthy controls: one with good SC abilities (Homogeneous SC group) and two with specific weaknesses in complex Facial Emotion Recognition (Low FER group) or Affective Theory of Mind (Low AToM group). However, these patterns were not found in participants with schizophrenia, who were characterized rather by levels of SC functioning (i.e., Low, Medium and High SC groups). Importantly, while the High SC group (47.9% of the sample) exhibited normal performances, the two others were underpinned by different pathological processes (i.e., alexithymia for Medium SC group or neurocognition dysfunctioning for Low SC group). These results have important implications for future research as well as for clinical practice regarding assessment methodology and therapeutic interventions.
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PMID:What are the specificities of social cognition in schizophrenia? A cluster-analytic study comparing schizophrenia with the general population. 3059 41