Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


Int J STD AIDS
PMID:Miliary Pneumocystis carinii pneumonia in acquired immunodeficiency syndrome. 154 70


Int J STD AIDS
PMID:Erythema multiforme as a presentation of human immunodeficiency virus seroconversion illness. 154 71


Int J STD AIDS
PMID:Herpetic adhesions causing dyspareunia. 148 3


Int J STD AIDS
PMID:The presence of HTLV-I/II in non-intravenous drug using Spanish prostitutes. 154 73


Int J STD AIDS
PMID:Audit of a genitourinary-based colposcopy service. 154 74


Int J STD AIDS
PMID:AIDS Literature Index. 154 75

Glutathione (GSH) is a major antioxidant that protects tissues from free radical injury. Glutamine augments host defenses and may be important in GSH synthesis. Acetaminophen toxicity causes hepatic GSH depletion and hepatic necrosis. The authors hypothesized that glutamine-supplemented nutrition would enhance liver GSH stores and diminish hepatic injury and death after acetaminophen overdose. Wistar rats received either a standard total parenteral nutrition (TPN) solution (STD) or an isocaloric, isonitrogenous glutamine-supplemented solution (GLN). On the 5th day of feeding, animals were given acetaminophen (400 mg/kg intraperitoneally) and then killed at various time points. Standard TPN solution animals had a rapid depletion of hepatic glutathione, whereas GLN animals were resistant to this drop and rapidly repleted hepatic GSH stores. Glutamine-supplemented animals maintained higher plasma glutamine concentrations, had lesser elevations in hepatic enzymes, and sustained significantly fewer complications compared with STD animals. The authors conclude that glutamine-supplemented nutrition preserves hepatic glutathione, protects the liver, and improves survival during acetaminophen toxicity. Glutamine may augment host defenses by enhancing antioxidant protection.
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PMID:Glutamine preserves liver glutathione after lethal hepatic injury. 154 97

Sexual behavior, condom use, HIV knowledge, and anxiety in women were examined in order to understand the range of sexual behaviors, predictors of safer sex, and the extent of relapse. 153 women drawn from a pool of consecutive attenders at the Central London STD Clinic participated in this cross-sectional sample through interviews and questionnaires. 1/4 of the sample did not respond to safe sex and an additional 14% were unable to maintain it over time. Anxiety and knowledge did not differ between the safe and relapsed groups, but self-efficacy and cognitive variables did. Those who maintained safe sex had significantly less sex. 10% of the sample had unprotected anal intercourse. Most of the women were involved in longer term relationships; however 1/4 had sex outside of the relationship and 1/5 stated that their partners also did. HIV information gathering was passive and 74% felt they could not protect themselves against infection. High concern over HIV was monitored. Condom uptake was low for most of the participants and nonexistent for those who indulged in anal intercourse. 25% participated in HIV testing and these women did not differ significantly in terms of their behavior from those women who went untested. HIV risks for women are a source of anxiety and tailored intervention is necessary to reduce risk and promote dialogue and negotiation.
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PMID:Safe sex and women. 160 8

The risk factors for infection with the human immunodeficiency virus (HIV) were assessed in individuals attending two different HIV antibody testing clinics: Genitourinary Medicine (GUM) and an HIV counselling and screening clinic (CSC) The risk of acquiring other sexually transmissible infections (STD) was also assessed, and all patients were offered STD screening. Fewer STDs were found in CSC patients than in GUM patients, but the results highlight the need to be aware of the possibility of other STDs whenever and wherever HIV antibody testing is undertaken.
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PMID:HIV testing and assessment of risk of other sexually transmitted diseases. 154 17

Molluscum contagiosum virus (MCV) lesions from 31 human immunodeficiency type 1 (HIV-1) positive patients and 54 HIV-1 negative adult control patients were examined for the presence and type of MCV DNA by high stringency Southern hybridization using 32P-labelled or digoxigenin-labelled MCV DNA probes. Of the 83 patients whose lesions contained detectable MCV DNA, 77 were infected with a single type of MCV (16 with MCV 1; 29 with MCV 1v; 30 with MCV 2; and 2 with MCV 2v). Five patients had apparent double infections, with hybridization results indicating the presence of various combinations of MCV 1 or 1v and MCV 2 or 2v. When these results were analysed in the light of clinical data no correlations were found between the MCV type(s) detected and the clinical stage of HIV-1 infection; nor between the MCV types and the anatomical site of the lesions or persistence of infection. However, the HIV-1 positive patients were significantly more likely to be infected with MCV types 2 or 2v than were the controls (17/29, 59% versus 15/48, 31%; P less than 0.05). Since a concurrent study of MCV lesions in children aged 15 years or less has shown that the percentage of infections attributable to MCV 2 or 2v is extremely small (3%), this finding suggests that MCV lesions in HIV-1 positive patients are attributable to adult-acquired MCV infection rather than to reactivation of a childhood infection.
Int J STD AIDS
PMID:Clinical and molecular aspects of molluscum contagiosum infection in HIV-1 positive patients. 157 79


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