Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Consecutive cervical smears examined in 1980 were divided into those from women using IUDs (757) and those not using them (11,711). Actinomycetes were not found in the non-IUD group but were present in 7.0% of the IUD group and were significantly more common in women with plastic IUDs (11.7%) than those with copper ones (2.1%). Cervical intraepithelial neoplasia (CIN), grade 3, was significantly more common in the IUD group (1.06%) than in the non-IUD group (0.34%). Trichomonas infection was significantly more common in women with IUDs and actinomycetes (9.4%), in those with IUDs and without actinomycetes (1.6%), and in those without IUDs attending the clinic for sexually transmitted diseases (STD, 5.9%) than in non-IUD, non-STD women (0.7%). Candida infection was not more common in women with IUDs (with or without actinomycetes, 1.2%) than in non-IUD, non-STD women (2.1%) but was significantly more common in STD women (3.8%). A repeat study in 1981 showed a similar prevalence of CIN 3:1.03% of the IUD group (485) and 0.33% of the non-IUD group (10,850).
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PMID:Prevalence of cervical neoplasia and infection in women using intrauterine contraceptive devices. 715 84

A retrospective study of the results of cervical cytological screening of HIV-infected women attending an inner city ambulatory HIV clinic over a 6-year period between 1987 and 1992 was carried out. During this time a total of 165 HIV-infected women attended for management of their HIV disease. The results of cervical cytological specimens (smears) were available in 136 (82.4%) women. The risk categories for HIV infection of these 136 women were intravenous drug use 110 (80.9%), heterosexual sex 24 (17.6%) and undetermined 2 (1.5%). Eighty-five (62.5%) of the 136 women were classified CDC group 2, 30 (22%) CDC group 3, and 21 (15.5%) CDC group 4 at the time of initial cytological screening. Forty-one (30.1%) women had mild dysplasia/CIN 1, 21 (15.4%) had moderate dysplasia/CIN 2 and 17 (12.5%) had severe dysplasia/CIN 3. The overall prevalence of dysplasia/CIN was 58.1%. Twenty-seven (34.2%) of the women with dysplasia/CIN had cytological evidence of human papillomavirus infection. No association between the clinical stage of HIV disease and the presence or degree of dysplasia/CIN was demonstrated. Women with cytological evidence of CIN were significantly more likely to have had genital warts than those with no evidence of CIN (OR 3.1, CI 1.1-10). In those women with cervical dysplasia who underwent colposcopic examination, CIN was confirmed in a high proportion of cases. The default rate from colposcopy, however, was high (35.4%).
Int J STD AIDS
PMID:Cervical cytological screening in HIV-infected women in Dublin--a six-year review. 754 89

An audit of the use of colposcopy in women with anogenital warts was performed. Fifty women attending a clinic for sexually transmitted diseases in a District General Hospital with anogenital warts were examined by cervical cytology and colposcopy for cervical infection by human papillomavirus (HPV) or epithelial abnormality indicating cervical intraepithelial neoplasia (CIN) or both. Collated results showed a high prevalence of both conditions in these 50 women; 20 (40%) had evidence of cervical infection by HPV and 11 (22%) epithelial abnormalities consistent with CIN 1 or 2. However, neither CIN 3 nor invasive disease was detected. Colposcopy in this setting was shown to be a specific but insensitive tool and its role in the routine management of women with anogenital warts at our institution is not warranted.
Int J STD AIDS
PMID:Screening for cervical abnormalities in women with anogenital warts in an STD clinic: an inappropriate use of colposcopy. 784 24

The aim of the study was to compare the frequency of Chlamydia trachomatis infection in patients with cervical intraepithelial neoplasia (CIN) and in women without cervical pathology. In a study group of 423 patients with histologically proven CIN and in 108 controls with normal cervical smear, cytological material for direct immunofluorescence analysis was obtained. Among 423 patients, 24 (5.7%) had CIN 1, 108 (25.5%) CIN 2 and 291 (68.8%) CIN 3. Among all patients with CIN, 27 (6.4%) were C. trachomatis positive and 396 (93.6%) C. trachomatis negative. In the control group 6 (5.6%) were C. trachomatis positive and 102 (94.4%) C. trachomatis negative. The difference between C. trachomatis infection incidence in patients with CIN and in women without cervical pathology was not significant (chi2=0.29; P>0.05). In this study, no difference in C. trachomatis infection incidence was detected between patients with CIN and women with normal cervical smears. The impact of C. trachomatis infection seems not to interfere with the development or even the promotion of CIN.
Int J STD AIDS 1999 May
PMID:Chlamydia trachomatis infection in women with and without cervical intraepithelial neoplasia. 1066 5