Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a study to quantify epidemiological treatment given to female contracts for gonorrhoea and non-specific genital infection in STD clinics in England and Wales two-thirds of women treated for gonorrhoea during 1978 were named contacts, a quarter of whom received epidemiological treatment. Only 35% of cases treated in this way were subsequently confirmed microbiologically, but nearly 1000 unconfirmed cases were returned as if they were true cases of gonorrhoea. In view of modern culture techniques and the low default rates found in this study, there seems to be little justification for the use of epidemiological treatment for gonorrhoea. Of women who gave a history of exposure to non-specific urethritis, 86% received epidemiological treatment. The variation in diagnostic and notification criteria for non-specific genital infection results in virtually worthless statistics for female cases treated.
 ...
PMID:Epidemiological treatment gonorrhoea and non-specific genital infection in female sexual contacts. Current practices in STD clinics in England and Wales. 706 65

In an attempt to investigate the influence of the AIDS campaign on the number of cases of STD in Japan, the case numbers of both gonococcal and chlamydial urethritis diagnosed in Japanese Red Cross Medical Center (JRMC) from 1980 to 1992 were surveyed. The case number of gonococcal urethritis (GU) in JRMC increased from 1980 to 1984 reaching a peak case number of 300% of 1980. Since 1984 the number of cases decreased until 1989 returning to the same case number of 1980. After a slight increase in 1990 and 1991 the case number decreased to 20% of the peak number of cases of 1984. The above trend in case numbers for GU in JRMC is similar to national statistics. The increase seen up to 1984 is thought to be similar to the increase recorded in the 1970's in developed countries. The decrease after 1984 is assumed to be due to the AIDS campaign. No remarkable change was observed in the case numbers for chlamydial urethritis (CTU) in JRMC in the same period. The results suggest that the AIDS campaign had less effect on the case numbers for CTU than that of GU, because the source of CTU infection is not limited to partners defined as hypothetically risky under the AIDS campaign. Though the sites and the route of infection are identical with gonococcal infection, the symptoms of CTU are much less fewer and less severer than that of GU, and chlamydia genital infection has already spread into every social class in Japan. The proportion of the GU that was due to gonococcal urethritis infection from the female pharynx to whole case number of gonococcal urethritis increased. This may reflect ignorance concerning the role of the pharynx as an infectious sources of gonococcal urethritis.
 ...
PMID:[The effect of the AIDS campaign on case numbers of male urethritis]. 891 99

It is a retrospective study supporting 82 cases continued series of feminine sterility and which objective is to evaluate the nursing management quality of genital infection in exploration and treatment of sterility. Women mean age is 26 years old, sterility is most primary frequently (68%) and from fallopian origin (80%). Followers examinations have been asked: vaginal taking (100%), urines cytobacteriology examination (56%), syphilis serology (23%), chlamydia serology (57%), mycoplasma serology (03%). Genital infection have been diagnosed in 75% of cases, in 33% of cases positive Chlamydia serology was found. Three molecules have been used principally in treatment: cyclines 50%, imidazoles derived 47%, lactamines 15%. The upper cost of diagnostic and treatments produce a wishest of prevention which based is the tracking and the precocious treatment of STD.
 ...
PMID:[Sexually transmitted diseases and female sterility at the University Hospital Center of Dakar: management and prevention]. 906 54

To find what proportion of women with endocervical Chlamydia trachomatis infection had asymptomatic infection of the upper genital tract, 10 women with neither gonorrhoea nor signs, symptoms or a past history of pelvic inflammatory disease were laparoscoped. Swabs from the fimbriae and pouch of Douglas were tested for C. trachomatis by tissue culture, enzyme immunoassay, direct fluorescent antibody and polymerase chain reaction techniques. Four of the women had an upper genital tract chlamydial infection. Neither laparoscopic appearances, menstrual phase, interval since last intercourse, partner change nor other coincidental genital infection was associated with the upper genital tract spread. These findings suggest that careful investigation, immediate treatment and contact tracing are mandatory when asymptomatic endocervical chlamydial infection is discovered.
Int J STD AIDS 1997 May
PMID:Silent upper genital tract chlamydial infection and disease in women. 917 56

The management of cases of Chlamydia trachomatis genital infection diagnosed in clinics in Wessex in the last quarter of 1996 was surveyed, and the results compared with those obtained in the national gonorrhoea audit. Treatment regimens were extremely varied both between and within clinics. Overall, 71% of patients saw a health adviser, 74% returned for follow-up, and 96% of these were cured. Compared with the national gonorrhoea audit, fewer contacts were reported (1.2 vs 1.5), but more contacts were seen per index case (0.7 vs 0.5), and a higher proportion of contacts were seen (59% vs 33%). The figures were higher in those who returned for a test of cure. Little data were available for contacts attending elsewhere for treatment; communication networks among genitourinary medicine (GUM) clinics are essential for effective contact tracing. Variations between clinics may reflect differences between the populations served as well as in diagnostic methods and management policies.
Int J STD AIDS 1998 Feb
PMID:The management of Chlamydia trachomatis genital infection in genitourinary medicine clinics in the Wessex region. 950 80

Inadequate treatment and follow-up of women with genital infection with Chlamydia trachomatis and Neisseria gonorrhoeae can cause long-term morbidity. Inadequate contact tracing can predispose to re-infection. As some women with genital infections present to agencies other than genitourinary medicine (GUM) clinics, improved liaison between these and GUM departments are important in safeguarding proper follow-up and contact tracing.
Int J STD AIDS 1998 Mar
PMID:Liaison between gynaecologists, microbiologists and genitourinary medicine clinics in the management of patients with genital chlamydia and gonococcal infections. 953 Sep 2

This is a study of 189 women attending a family planning clinic in rural South Africa to determine the prevalence of asymptomatic and unrecognized genital tract infections. Genital samples were taken from these women to diagnose infection with Neisseria gonorrhoeae, Chlamydia trachomatis, Trichomonas vaginalis, Candida albicans, Treponema pallidum, and HIV, and to diagnose bacterial vaginosis. Among the 189 women, 41 (22%) reported having had an STD treated in the preceding 12 months. By direct questioning, 74 women stated the following symptoms: genital itch -- 38 (20%); vaginal discharge -- 56 (30%); dysuria -- 33 (18%); dyspareunia -- 22 (12%); and genital ulcers -- 4 (2%). 45 (24%) women had more than one symptom. 119 (63%) women had at least one genital infection, and 49 (26%) had multiple infections. Most of the infections were asymptomatic; while those that were symptomatic, were unrecognized or not reported. Results showed a high prevalence of genital tract infection among the participating women, with most of their infections remaining asymptomatic or unrecognized. Thus, strategies to detect and treat genital tract infections in rural South Africa need to be developed.
 ...
PMID:Family planning services in developing countries: an opportunity to treat asymptomatic and unrecognised genital tract infections? 958 84

Chlamydia trachomatis is one the most important sexually transmitted diseases; it can cause serious sequelae despite the absence of symptoms in some people. It's estimated that about 25% of women who have acute salpingitis become infertile, and chlamydial infection is the commonest cause. The introduction of screening programs for its detection are still a topic of discussion. The literature shows that the total cost of examination and treatment of complications known to be associated with genital chlamydial infection (PID, chronic pelvic pain, tubal factor infertility) is generally higher than the total cost of a large-scale Chlamydia screening program. The selection of a diagnostic test for detection of chlamydial genital infection depends on availability, local expertise, and prevalence of Chlamydia trachomatis in the test population. Cell culture is too expensive in nonendemic regions, so the use of non-culture techniques is very attractive. PCR (polymerase chain reaction) and LCR (ligase chain reaction) are actually the two most commonly used alternatives to conventional methods for detecting STD agents. In fact, PCR and LCR have proved useful for detection of Chlamydia trachomatis in cervical and urethral samples both in symptomatic and asymptomatic women. Recently, testing of first-void urine (FVU) specimens with these techniques has shown that the amplification tests are as sensitive as tests with endocervical swab cultures.
 ...
PMID:Update on Chlamydia trachomatis. 1081 17

Chlamydia trachomatis is increasingly being identified outside of genitourinary medicine (GUM) clinics, concern has been expressed about the management of these patients. An audit was undertaken on a group of women identified with chlamydia in family planning clinics (FPCs) in Southampton. Forty-seven women were identified positive over a period of one year. Fifty-nine per cent attended a GUM clinic for treatment, 15% were treated at family planning clinics or by their general practitioners (GPs) but 26% remained untreated. The median time from knowing the positive result to attending GUM was more than 3 weeks in 27%. In those that attended GUM, 44% had an associated genital infection and 79% of named sexual partners were traced. As a result of the audit, a new protocol has been introduced in the family planning clinics for the management of women found to have chlamydia.
Int J STD AIDS 2000 Nov
PMID:Audit of outcome following positive chlamydial test results in family planning clinics in Southampton. 1108 92

All patients, who presented at the Sexually Transmitted Disease clinic of the University College Hospital, Ibadan, between the period of August 1996 and January 1998 were included in this study. They were examined for genital infections in order to determine the prevalence rate of Human papilloma virus genital infection (genital warts) among them. Out of the 1,373 patients seen in the clinic during the period, 861 (62.71%) had STD while the remaining 512 (37.29%) had other conditions. Out of these 861 cases, 69 (8.01%) had HPV genital infection, while the remaining 792 (91.9%) had other STDS. Of these 69 cases of genital warts, 35 (50.7%) were males while 34 (49.3%) were females. Their ages ranged between 17 and 74 years, with the peak incidence in the 20-29 years age group. 32 (46.4%) had concurrent genital infections with non-gonococcal urethritis and cervicitis 9(13%) constituting the most common type. The highest incidence (36.2%) of this condition was found among petty traders while the lowest was found among the business executives and applicants. In 67 (97%) of these patients, the nature of sexual intercourse was vaginal, while in 1 (1.5%) it was oral and another 1 (1.5%) both vaginal and oral. 26 (37.7%) of the patients had just one sexual partner, while 7 (8.1%) had 2 or more. Only 2 (2.9%) admitted to have had any sexual contact with commercial sex workers. The sites of warts in males include the shaft of the penis, the glans penis, perineum and intrameatum. In females, warts were found in the vulva, vagina, cervix, perineum and perianal regions. 42 (60.9%) of these patients were placed on 20% podophyllin on tincture of benzoin, 17 (24.6%) on cryotherapy and 1 (1.5%) on both. They all did well on the different treatment regimens except for 1 (1.5%) that had to change from podophyllin to cryotherapy when there was no reduction in size. 11 (15.9%) were however lost to follow up.
 ...
PMID:Prevalence of human papilloma virus genital infections in sexually transmitted diseases clinic attendees in Ibadan. 1112 83


<< Previous 1 2 3 4 5 Next >>