Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

One hundred and fifty women who attended the routine genitourinary medicine (GUM) clinic at the Leicester Royal Infirmary (LRI) between August 1993 and February 1994 completed a questionnaire enquiring into a past history of sexual assault. Of these, 52 (34.7%) confirmed that they had been assaulted previously, 18 below the age of 16, 22 after this age and 12 in both age groups. Non penetrative abuse was most common in those violated as minors and vaginal penetration in women assaulted over the age of 16. The strongest demographic indicator for sexual abuse among this study group was that of a current divorced/separated marital status. Assailants of minors were most likely to be someone known to the family whereas male intimates accounted for a third of assaults on older women. Sexual dysfunction was acknowledged by approximately half of those previously assaulted as a sequelae of abuse. It is important that GUM physicians remain alert for sequelae of sexual abuse and offer services appropriate to the victim's needs.
Int J STD AIDS
PMID:The prevalence of previous sexual assault among routine female attenders at a department of genitourinary medicine. 911 63

We present the British Association for Sexual Health and HIV (BASHH), Special Interest Group for Sexual Dysfunction updated recommendations for the management of premature ejaculation. The recommendations outline the physiology, prevalence, definitions, aetiological factors and patient assessment for this common sexual problem. Behavioural, local and systemic pharmacological treatments are discussed along with general recommendations and auditable outcomes.
Int J STD AIDS 2006 Jan
PMID:Recommendations for the management of premature ejaculation: BASHH Special Interest Group for Sexual Dysfunction. 1640 70

We present the British Association for Sexual Health and HIV (BASHH) Special Interest Group for Sexual Dysfunction recommendations for the management of vaginismus. The recommendations outline the history, prevalence, aetiological factors, patient assessment and management for this sexual problem. Treatment strategies are discussed along with general recommendations and auditable outcomes.
Int J STD AIDS 2006 Jan
PMID:Recommendations for the management of vaginismus: BASHH Special Interest Group for Sexual Dysfunction. 1640 72

Women form an increasing proportion of HIV-infected individuals in the developed world. Early data suggest that women with HIV are at particular risk of developing sexual problems. The aim of this study was to describe our anecdotal experience of HIV-infected women and to ascertain their sexual dysfunction, and also to conduct a national survey to evaluate what sexual dysfunction services are provided for women in other UK HIV centres. Retrospective analysis of clinic notes of women attending our HIV clinic and letter surveys of HIV centres in the UK were carried out. About half our cohort reported that they had sexual problems or were not satisfied with sex over the preceding 12 months. Contextual issues seemed to be the commonest cause of these problems. Sixty percent of HIV physicians in the UK rarely/never ask their female HIV patients about sexual functioning. Sexual dysfunction is probably common in HIV-infected women. Most physicians seeing women with HIV in the UK do not ask about sexual functioning. 'Physician coaching' could help to redress this situation, so that at the least the sexual problems could be brought up in discussion.
Int J STD AIDS 2006 Oct
PMID:HIV-associated female sexual dysfunction - clinical experience and literature review. 1705 42

Where men have had access to successful treatment for HIV (highly active antiretroviral therapy), expectations of both patients and physicians alike have changed significantly over the past decade. Such men, living with HIV, expect to lead fully functional lives including a normal sex life. Sexual dysfunction is well described among men with HIV. We retrospectively analysed details of 190 consecutive men attending a dedicated sexual dysfunction service in our HIV unit over an 18-month period. We took note of the specifics of their HIV disease, illnesses other than HIV, as well as other risk factors associated with sexual dysfunction. Men with sexual dysfunction all commonly reported recreational drug use, hepatitis B and C co-infection, anxiety and depressive illnesses, peripheral neuropathy and lipodystrophy. There was a significant relationship between men complaining of retarded ejaculation and peripheral neuropathy. Sexual dysfunction in non-HIV settings is known to lead to poor adherence to prescribed medications, e.g. antihypertensive agents. Iatrogenic sexual dysfunction in patients may similarly have a potential to lead to poor antiretroviral compliance if not addressed.
Int J STD AIDS 2006 Nov
PMID:Factors associated with sexual dysfunction in men with HIV infection. 1706 82

Sexual difficulties are common in people attending genitourinary (GU) medicine/HIV services and many would like professional help. Here, we report the results of the BASHH Special Interest Group in Sexual Dysfunction (SD) survey on the level and type of SD service provision within UK GU medicine services in 2007. Many clinicians expressed an interest in SD, however, only 25% of GU medicine clinics provide a designated SD service. Marked regional variation in the level of service provision was highlighted. Lack of resources and other pressures on GU medicine services, notably 48-h access, are barriers to SD service development. In spite of these constraints, we argue that GU medicine clinics are a highly appropriate place to treat SD.
Int J STD AIDS 2008 Jan
PMID:Sexual dysfunction service provision in UK genitourinary medicine clinics in 2007. 1827 43