Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.10.2 (
focal adhesion kinase
)
44,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Bruton's tyrosine kinase
(
Btk
) is known to be involved in a broad array of signal transduction pathways necessary for the proliferation, survival and development of B cells. Mutations in the
Btk
gene are causually linked to the development of X-linked agammaglobulinemia (XLA) in humans. We show here, that CD40 ligation leads to tyrosine phosphorylation of
Btk
in the human immature B cell line MHH-
PREB
-1. Even though the CD40-mediated tyrosine phosphorylation of
Btk
is less efficient than that mediated through the B cell receptor, CD40 stimulation results in a marked and continous activation of
Btk
in MHH-
PREB
-1 cells and, to a lesser extent, in a transient
Btk
activation in Daudi cells. Furthermore, in Daudi cells we observed that tyrosine phosphorylation and activation of
Btk
is correlated with its translocation from the cytosolic to the membraneous fraction. These data suggest that, in addition to the BCR, CD40 is a surface receptor through which the activity of
Btk
can be stimulated in human B cells.
...
PMID:Bruton's tyrosine kinase is activated upon CD40 stimulation in human B lymphocytes. 1243 73
