Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
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Our objective was to determine the prevalence of sexual dysfunction among new heterosexual attendees at a central London genitourinary medicine (GUM) clinic. We carried out a cross-sectional study in which patients completed a self-administered questionnaire-the Golombok-Rust Inventory of Sexual Satisfaction (GRISS) and participated in a brief interview during which additional information was sought regarding the patient's sexual history. An overall transformed score of >5 on the GRISS was defined as indicative of overall sexual dysfunction and a score of >5 on any of the subscales as indicative of a specific sexual dysfunction. Twenty-five (24%) men and 10 (9%) women had a GRISS score in keeping with overall sexual dysfunction, the prevalence being significantly lower in women (P=0.01, chi2=6.56, 1df). Sixty-three men (59%) and 63 (60%) women produced scores indicative of significant abnormality on at least one subscale, including, in men: erectile dysfunction 20 (19%), premature ejaculation 23 (22%), and in women: vaginismus 26 (25%) and anorgasmia 23 (22%). Neither an abnormal overall or subscale score on the GRISS was associated with a current STD on KC60 diagnosis or a history of sexual assault for either men or women. There is a substantial prevalence of sexual dysfunction in new heterosexual attendees at our clinic, the service implications of which need to be addressed.
Int J STD AIDS 1997 May
PMID:Prevalence of sexual dysfunction in heterosexual patients attending a central London genitourinary medicine clinic. 917 51

Switzerland's videotex computer sex education program in French is a telematic service set up in youth centers, schools and post offices, or for a monthly home rental charge of 9 swiss francs. German and Italian versions will be available by the end of 1991. CIAO receives 100 calls a month, or 20,000 screen page consultations. Anonymity is assured for caller and specialist through identification by pseudonym. This article discusses the experience of 2 trained specialists, a social worker and a sex education teacher, who answer questions. 70% of callers are boys, perhaps due to greater familiarity with computers, and to public location and freer attitude talking about sex in a group. Girls may use family planning centers for their questions. The typical boys 13-15 years questions concern anatomy and the size of the penis, breast stimulation, masturbation. Guilt and fear of consequences are communicated. Adolescents tend to focus on relationships, with shyness a typical pattern. There is expressed concern for whether it's OK to sexually explore certain sex zones, and what tells me she's happy. Communication between partners about sex is the difficulty and specialists emphasize asking the girl herself how she feels. With increasing age, the focus is very specific; i.e., premature ejaculation, STD's, homosexuality, but also with concern for knowledge about normal love-making and worry about not wanting it enough. In general, questions tend to be bound by traditional roles and questions on contraception are rare. Condom questions are usually related to AIDs. Questions express self-doubt and honesty, which sometimes focuses on the tragedy of sexual abuse, rape, AIDS, and suicide. Specialists find the work rewarding and helpful in sex education discussions in the classroom; great respect for young people is generated.
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PMID:Switzerland's videotex computer sex education programme. 1234 75

Premature ejaculation is a common sexual problem which presents to genitourinary (GU) medicine services. Five main treatment approaches have been used in clinical trials: behavioural therapy, antidepressants, phosphodiesterase-5 (PDE5) inhibitors, topical anaesthetic agents and alpha-blockers. We have carried out a systematic review of published pharmacological trials. All antidepressants appeared to delay ejaculation to some extent at all doses. Anaesthetic creams appeared to be as successful in slowing ejaculation as antidepressants without systemic side-effects, although some patients did experience erectile problems or unpleasant local symptoms. Anecdotally, behavioural therapy is effective and appears to have long-lasting efficacy. There is a need for quality comparative trial of behavioural therapy, topical anaesthetic agents and antidepressants, including appropriate measures of relapse, follow-up and acceptability of continuing long-term treatment.
Int J STD AIDS 2005 Oct
PMID:A review of controlled trials in the pharmacological treatment of premature ejaculation. 1621 10

Premature ejaculation is a common male sexual dysfunction. Treatment modalities as recommended by the British Association of Sexual Health and HIV include behavioural therapy, tricyclic antidepressants, selective serotonin reuptake inhibitors (SSRIs) and local anaesthetic creams. We audited the clinical cohort from our dedicated sexual dysfunction clinic to determine the success of prescribed treatment and co-existing prostatitis/male pelvic pain, erectile dysfunction, phosphodiesterase-5 (PDE5) inhibitor use and anxiety. The use of SSRIs was successful in the treatment of premature ejaculation with or without the use of local anaesthetic cream. Co-existing prostatitis/male pelvic pain, erectile dysfunction, PDE5 inhibitor use and anxiety were high.
Int J STD AIDS 2005 Oct
PMID:Pharmacological treatment for premature ejaculation. 1621 22

We present the British Association for Sexual Health and HIV (BASHH), Special Interest Group for Sexual Dysfunction updated recommendations for the management of premature ejaculation. The recommendations outline the physiology, prevalence, definitions, aetiological factors and patient assessment for this common sexual problem. Behavioural, local and systemic pharmacological treatments are discussed along with general recommendations and auditable outcomes.
Int J STD AIDS 2006 Jan
PMID:Recommendations for the management of premature ejaculation: BASHH Special Interest Group for Sexual Dysfunction. 1640 70

Premature ejaculation (PE) is the most common male sexual problem worldwide affecting 22-38% of men. It has a significant morbidity both on patients and their partners, causing distress, anxiety and relationship difficulties. The mainstay of treatment is a combined approach using behavioural therapies and non-licensed medication such as topical anaesthetic preparations, selective serotonin re-uptake inhibitors and phosphodiesterase-5 inhibitors. In recent years, there has been a greater emphasis placed on researching novel treatments and exploring the on-demand use of current preparations. This review provides an overview of current accepted treatments and emerging agents for the use in PE.
Int J STD AIDS 2010 Feb
PMID:Premature ejaculation: treatment update. 2008 91

We describe the use of a non-prescribed aid (Black stone) for premature ejaculation that resulted in a chemical burn on the penis with an appearance similar to severe balanitis.
Int J STD AIDS 2014 Aug
PMID:Black stone - a natural remedy for premature ejaculation and performance enhancement, or maybe not? 2445 32