Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Pelvic inflammatory disease (PID) is a common condition presenting to Genitourinary Medicine clinics in the UK. It is unclear what is the best therapeutic option in the outpatient setting. A clinical audit of current standard of care in women presenting with PID was conducted. A total of 150 women were diagnosed clinically during a six-month period. Chlamydia and gonorrhoea were identified in 30% and 4% of patients respectively. The clinical and microbiological cure rates of oral doxycycline and metronidazole were assessed. In 57% of patients their symptoms resolved, but 18% had persistent signs and symptoms; 25% did not attend for follow up visit. Partner notification was discussed in 87% of patients. With a treatment failure rate of 18% we felt it appropriate to change the antibiotic regimen of PID in our department.
Int J STD AIDS 2002 Aug
PMID:An audit of outpatient management of pelvic inflammatory disease. 1219 44

Infertility is very common in some areas of Africa, and accounts for a significant proportion of the demand for health services in some countries. Infertility has profound social implications, as blame is often assigned to the woman and she is frequently divorced. Infertility must be distinguished from pregnancy wastage as they have different etiologies, necessitating different control strategies. Primary infertility is common in some countries, with considerable differences between countries. In Zaire, 22.1% of women aged 25-29 are childless, with rates up to 46.2% in some areas, as opposed to rates of 17% in the Congo, 26% in Mali, and 7.2% in Upper Volta. Worldwide, there is a "core" infertility rate of 5% due to chromosomal, congenital and endocrinologic factors. Rates above this are indicative of acquired infertility, of which the most common cause in women is infectious salpingitis. In the World Fertility Study, all 4 African countries studied had 2ndary infertility rates above the mean. Infectious salpingitis can also cause 1st degree infertility if acquired at a young age. Data from developing countries implicate tubal factors as the main cause of infertility. A WHO study found that bilateral tubal occlusion is 3x as frequent in Africa as in other developing areas (49% vs. 11%) as a cause of infertility. 85% of African women had an infectious etiology (vs. 36%). Pelvic inflammatory disease (PID), the main cause of tubal blockage, causes infertility in 15% of women after 1 bout. Various studies have shown that PID in Africa is caused mainly by N. gonorrhoea (38 to 46%) and C. trachomatis (21 to 23%). PID in Africa occurs commonly after childbirth and abortion, with the same pathogens. STDs may also cause male infertility by blockage of the sperm ducts or decreased sperm count. Thus, STD is responsible for a large proportion of infertility in Africa and preventing STD is a major part of reducing infertility.
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PMID:Determinants of infertility in Africa. 1228 Nov 23

Pelvic inflammatory disease (PID) remains a significant cause of morbidity worldwide, with the potential to result in serious reproductive complications. Much of the definitive work regarding PID was completed in the 1960s and 1970s. More recently, however, there have been a range of studies published that have contributed to our understanding of PID. Aetiologically, the main pathogens are chlamydia and gonorrhoea, but may include Mycoplasma genitalium and anaerobic Gram-negative rods. Risk factors associated with the development of PID include inconsistent barrier contraception, possibly vaginal douching, and the oral contraceptive pill likely masking the clinical severity of the disease. The small risk associated with the intrauterine device is limited to the first few weeks after insertion. New diagnostic techniques being evaluated include Doppler ultrasound and magnetic resonance imaging. Management must be prompt to prevent complications, and there are no apparent differences in clinical outcomes, whether treated as an inpatient or outpatient. Effective disease prevention includes widespread chlamydia screening and improving education.
Int J STD AIDS 2005 Nov
PMID:A review on pelvic inflammatory disease. 1630 62

Pelvic inflammatory disease (PID) remains one of the most important consequences of sexually transmitted infections (STIs) resulting in severe morbidity and acting as the economic justification for STI screening programmes. Early and appropriate therapy has the potential to significantly reduce the long-term complications of PID, and these evidence-based guidelines provide advice on the management of pelvic infection including the use of appropriate antimicrobial regimens.
Int J STD AIDS 2007 Oct
PMID:European guideline for the management of pelvic inflammatory disease. 1794 43