Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sexually transmitted infection (STI) rates among men having sex with men continue to increase. HIV services may operate independently to genitourinary medicine clinics and the sexual health of HIV-positive patients may be of low priority in the context of medical problems related to HIV. A prospective study of HIV-positive gay men was conducted in a London outpatient clinic over a three-month period. Data were available for 90 men. Forty-five percent had STI screens in the preceding six months. These revealed a high rate of infections; 26 infections diagnosed in 14 men in the study period. Fifty-seven percent of the 90 men in the study had more than one partner in the past three months and approximately one-third had unprotected sexual activity. A significant proportion of men were unaware of recent outbreaks of hepatitis C and lymphogranuloma venereum and of HIV postexposure prophylaxis. We therefore recommend that sexual history-taking, STI screens and health promotion should become a routine feature of HIV outpatient consultations in this group.
Int J STD AIDS 2008 Oct
PMID:Tackling STI epidemics through the HIV clinic: is sex high enough on the agenda? 1882 26

We report on a 37-year-old woman who presented with a six-week history of bilateral, tender lymph nodes in her groin. An initial biopsy was done with the histology 'suggestive of lymphogranuloma venereum (LGV)'. She had not had sexual intercourse for over two years and had no symptoms or signs of note to report. Examination revealed large, smooth tender lymph nodes above the inguinal ligament bilaterally with no other areas of lymphadenopathy. Due to a possible diagnosis of LGV, three weeks of doxycycline was given. A further review of the histology slides revealed 'subacute necrotizing lymphadenitis' highly suggestive of Kikuchi-Fujimoto syndrome of unknown cause, which is usually self-limiting. Subsequent follow-up of the patient revealed a reduction in the lymph nodes size with little tenderness.
Int J STD AIDS 2009 Feb
PMID:Kikuchi-Fujimoto syndrome presenting to a sexual health clinic. 1918 65

We report the case of a patient who presented to a clinic for evaluation of inguinal lymphadenopathy. Histology of the lymph nodes revealed micoabscess formation suggesting infection with Lymphogranuloma venereum (LGV) or Bartonella henselae--the causative agent in cat scratch disease (CSD). The patient recalled no preceding animal exposure. Clinical and serological findings initially suggested early LGV but convalescent serology supported CSD. This serves as an important reminder that B. henselae infection should be considered a cause of regional lymphadenopathy in individuals suspected of having LGV.
Int J STD AIDS 2009 Aug
PMID:Cat scratch disease: a diagnostic conundrum. 1962 97

Screening for rectal chlamydia was not routinely offered in our department until we had a local outbreak of lymphogranuloma venereum (LGV) in men who have sex with men (MSM) in 2004/2005. We later decided to extend the screening to high-risk women (women who had receptive anal sex, contacts of gonorrhoea, women, with anorectal symptoms, women who had been sexually assaulted). A retrospective study of 152 women from whom 160 rectal chlamydia swabs were taken was carried out. Twenty (12.5%) swabs were positive, 19 of which were also positive at the cervix. All were non-LGV serovars. The groups at greatest risk were high-risk women aged less than 20 years and women with proven gonococcal infection where the prevalence was 22.6% and 30%, respectively. We conclude that rectal chlamydial infection in women may be common and further studies are needed to elucidate its importance.
Int J STD AIDS 2010 Feb
PMID:Rectal Chlamydia trachomatis infection in women. Is it overlooked? 1991 39

Lymphogranuloma venereum (LGV) is a sexually transmitted infection caused by Chlamydia trachomatis serovars L1, L2 and L3. Consequently, more specific and sensitive detection methods that are rapid and inexpensive are necessary to differentiate between C. trachomatis serovars. The purpose of this study was to identify and differentiate LGV-related C. trachomatis serovars from rectal swabs using high-resolution melting analysis (HRMA) and multiplex allele-specific polymerase chain reaction (MAS-PCR). Fifteen clinical samples from patients in Sydney were first screened and confirmed as C. trachomatis by using the COBAS AMPLICOR PCR analyser. The same samples were assayed for C. trachomatis and LGV by HRMA and MAS-PCR of the polymorphic membrane protein H (pmpH) gene. Both methods indicated that two of 15 samples were serovar L2 and the remainder (13/15) other C. trachomatis serovars. Both HRMA and MAS-PCR are inexpensive, rapid, easy methods that are useful tools for the identification of LGV in clinical and research laboratories.
Int J STD AIDS 2010 Feb
PMID:Differentiation of Chlamydia trachomatis lymphogranuloma venereum-related serovars from other serovars using multiplex allele-specific polymerase chain reaction and high-resolution melting analysis. 2008 94

Chlamydia trachomatis, serovar L2, is the causative agent of lymphogranuloma venereum (LGV), which during recent years has been responsible for various outbreaks reported among men who have sex with men (MSM) in Western Europe, America, Canada and Australia. Samples from nine patients with chronic proctitis, seen at a local hospital were sent to us for identification of C. trachomatis serovar L2. The presence of C. trachomatis serovar L DNA was identified by realtime polymerase chain reaction (PCR) in two patients. They both had high positive C. trachomatis antibody titres (>/=10,000) and were found to be infected with serovar L2b by sequencing after amplification of the omp 1 gene by a nested PCR technique. These two individuals met the diagnostic criteria for LGV serovar L2b infection and, to our knowledge, these are the first cases described in Portugal.
Int J STD AIDS 2010 Apr
PMID:Lymphogranuloma venereum serovar L2b in Portugal. 2037 98

Sexually transmitted infections (STI) or diseases (STD) are sociologic markers reflecting sexual behaviours of individuals belonging to this society. Since 2000, the evolution of STI has been characterized by the recrudescence of syphilis, the appearance of resistance of gonococcus to fluoroquinolones and the emergence of lymphogranuloma venereum. These STI are nearly exclusively observed in men and predominantly in men having sex with men with a high proportion of HIV infected individuals from 15% in those consulting for gonococcemia to 100% in those diagnosed with lymphogranuloma venereum. The epidemic is relatively stable since 2007 which suggest that it could decline in the next future. Relapse of these STI suggests a relapse of high risks sexual practices in group of patients historically exposed to HIV and that control measures for prevention of STI targeting men having sex with men should be reinforced for controlling the incidence of classical STI and of HIV.
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PMID:[Sexually transmitted infections in France in 2009]. 2046 28

We performed an audit on the management of lymphogranuloma venereum (LGV) against the British Association of Sexual Health and HIV (BASHH) guidelines. Sixty-three cases of LGV were diagnosed in 60 men who have sex with men (MSM). Fifty-six out of 63 (89%) episodes were treated in accordance with the guidelines. Although all eligible patients were offered an HIV test, 10% and 29% of patients were not offered syphilis or hepatitis C tests, respectively, at the time of LGV diagnosis. Partner notification was not possible in a third of cases. Several patients were re-infected with rectal Chlamydia trachomatis in the three months following LGV diagnosis, emphasizing the importance of rescreening to detect new infections as well as treatment failures in MSM at ongoing high risk of sexually transmitted infection acquisition.
Int J STD AIDS 2010 Nov
PMID:An audit on the management of lymphogranuloma venereum in a sexual health clinic in London, UK. 2118 61

A 44-year-old man who has sex with men presented with a three-month asymmetrical polyarthropathy. He had a positive HIV-1 antibody test consistent with infection acquired more than six months previously. Lymphogranuloma venereum (LGV)-associated DNA was detected from a rectal swab. Following successful treatment for LGV his arthritis resolved completely. Infection with HIV-1 has been hypothesized to cause reactive arthritis but this has been disputed. The most likely diagnosis in this patient was sexually acquired reactive arthritis secondary to LGV infection. As LGV can be asymptomatic and treatment differs from that of the other serovars, screening should be considered in all men who have sex with men (MSM) presenting with acute arthritis, particularly if they are HIV infected.
Int J STD AIDS 2011 Jan
PMID:Acute seronegative polyarthritis associated with lymphogranuloma venereum infection in a patient with prevalent HIV infection. 2136 72

A 41-year-old HIV-positive man who has sex with men (MSM) with a family history of deep vein thrombosis (DVT) presented to the emergency department with an acutely swollen lower limb. The initial clinical diagnosis was of a possible DVT and the patient was anticoagulated. However, investigations subsequently excluded DVT and sexually acquired reactive arthropathy (SARA) was eventually diagnosed. This complication followed an earlier attendance at the emergency department, where proctitis due to lymphogranuloma venereum (LGV) infection went unrecognized. This is the first reported case of LGV infection mimicking a DVT. Prompt recognition and treatment of the initial proctitis may have prevented the development of SARA.
Int J STD AIDS 2012 Mar
PMID:Complicated lymphogranuloma venereum infection mimicking deep vein thrombosis in an HIV-positive man. 2258 80


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