Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Registered Prostitutes are seen weekly for medical examination in the STD-Clinic of the Public Health Office Vienna. 1987 no syphilis was seen in this special riskgroup. The incidence of both gonorrhoe and chlamydial infection was. Chlamydias were found 1.6 times more, as gonococcal infections. There was no evidence of HIV infection. Screening for cervical neoplasia was started in reduced. 1988 and yielded a tenfold incidence of abnormal findings, requiring conisation often than compared to preventive checkups amoung the general female population.
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PMID:[The current examination protocol for prostitutes at a venereal disease counseling clinic, Vienna Public Health Service]. 252 78

Persons who are receiving evaluation and treatment for sexually transmitted diseases are at moderately increased risk for acquiring HIV infections. The scope of STD clinic services should be broadened to include counseling, education, and referral services for health needs related to risk of HIV infection.
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PMID:Prevalence of risk behaviors and HIV infection in Maryland STD clinics. 261 74

N-Myristoyl transferase (NMT) activity was measured in rat liver and H9 cells using an in vitro assay based on acylation of synthetic peptides. Glucosamine was found to inhibit the NMT activity. Using a synthetic peptide mimicking the N-terminus of HIV p27nef a Km value of 2.4 microM and a Vmax of 240 pmol/mg per h was found. In the presence of glucosamine the Vmax was lowered indicating that glucosamine acted as a non-competitive inhibitor. Glucosamine also inhibited incorporation of radiolabelled myristic acid into H9 cell proteins in vivo. In liver cells using a peptide from the N-terminus of p60 SRC only the Vmax was affected.
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PMID:Inhibition by glucosamine of myristoylation in human H9 lymphocytes and rat liver cells. 268 32

Using a postal questionnaire, a random sample of 1000 general practitioners throughout New Zealand were surveyed about their contacts with patients concerning AIDS or HIV infection and about their needs for information on AIDS related matters. A response rate of 86% was achieved. Almost all doctors (95%) had had some contact with patients concerning AIDS during the previous 12 months and 86% had had at least one request for the HIV antibody test. Taking blood samples for HIV testing was quite commonly performed by the doctor in the surgery, rather than referring the patient elsewhere. Referral to a specialist AIDS or STD clinic was rare. Continuing education was requested by most doctors. Specific information topics of interest included personal safety, patient care and ethical issues.
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PMID:AIDS and general practice. 276 94

Between 1982 and July 1987, more than 1200 patients attending St Stephen's Hospital were found to be HIV antibody positive. Four hundred were inpatients and most of the outpatients attended the sexually transmitted disease clinic. Two hundred and twenty-one patients had AIDS, 480 HIV-related disorders and 500 were asymptomatic. Most inpatients had invasive procedures within the operating theatres and there were 25 postmortems. Four hundred and five antibody tests from 220 health care workers from the STD clinic, operating theatres, isolation ward, intensive care unit and clinical laboratories were voluntarily tested for HIV antibody by an ELISA screening method. All were negative, except one male nurse who had other risk factors. Twenty-nine staff suffered needlestick injury with blood of HIV antibody positive patients; none has developed serological evidence of HIV infection.
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PMID:Serological studies on health care workers caring for patients with human immunodeficiency virus. 290 25

The 1st generation of serological tests for anti-HIV-1 gave so many false positives with African sera that it was wrongly postulated that the virus was endemic in Africa. As there is no simian or other virus sufficiently closely related to HIV-1 as to suggest a recent common ancestor, the evolution of HIV-1 is obscure and there is no evidence to support the hypothesis of an African origin. However, the similarity of HIV-2 to SIV and its geographical distribution do suggest an evolution of this virus in west Africa. The earliest anti-HIV-1 positive serum was from a subject in Kinshasa in 1959. Seroprevalence rose in pregnant women in Kinshasa from 0.25% in 1970 to 3.0% in 1980 and 5.7% in 1986. When 2 sexually promiscuous groups are compared, seropositivity rose sharply in female prostitutes in Nairobi from 4% in 1981 to 59% in 1984 and 64% in 1986, a curve which is approximately parallel to, but 3 years later than that of homosexual males in San Francisco. In central and east Africa, HIV-1 is now epidemic from Congo to Kenya and from Uganda to Zimbabwe. In west Africa, both HIV-2 and HIV-1 are epidemic; seroprevalence of HIV-2 is highest in southern Senegal, Guinea-Bissau, and Cote d'Ivoire: HIV-1 had the highest frequency in Cote d'Ivoire and Ghana. HIV-2 has not been reported, and HIV-1 is pre-epidemic in Africa north of the Sahara, Nigeria, Angola, MOzambique, and southern Africa, being found at significant frequency only in female prostitutes, patients with STD, or, in Morocco and South Africa only, in male homosexuals. Seroprevalence is greatest in female prostitutes and patients with STD; infection is more frequent in urban than in rural populations, except in Uganda. The peak frequency is at 30-34 years in males and 20-24 years in females. Other groups at risk are infants born to infected mothers, and those requiring blood transfusions, especially preschool children, patients with sickle cell disease, and pregnant women. The doubling time for seropositivity is about 1 year in the sexually active age range in some populations. Even at existing seroprevalence, decimation or worse of the most productive age groups is inevitable during the next few years in certain countries. Accelerated progression of the disease during pregnancy will lead to higher morbidity and mortality among fertile women than among men. The recent reductions in infant and childhood mortalities will be reversed, and populations may decline. Devastating social, economic, and demographic consequences are forecast. (author's)
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PMID:Seroepidemiology of human immunodeficiency viruses in Africa. 319 Dec 7

The epidemiology of HIV infection emphasizes the need to be able to identify and communicate with female prostitutes as a group. Health education, screening and the prevention of STD in female prostitutes remains an essential priority for the well-being of the prostitutes, their clients and the health of society. However, these goals will not be achieved by compulsory screening, as this will miss the highest risk group. Instead, increased official recognition and measures to encourage female prostitutes to participate in and communicate with the health care system may result in an improvement in our management of these women.
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PMID:Female prostitutes and sexually transmitted diseases. 330 94

This study investigated AIDS and STD knowledge, risk behaviors and condom use among clients of female commercial sex workers in Bali, Indonesia. Although these clients were varied in their socioeconomic status, they all tended to have low levels of knowledge concerning HIV and STD transmission and prevention, multiple sexual partners, low frequencies of condom use with these partners, and experienced frequent STDs. Although HIV sero-prevalence rates are currently low in Indonesia, clients of CSWs are at high risk of HIV transmission. Given their high mobility and frequent sexual encounters with CSWs in other parts of Indonesia, these men could well be agents of rapid spread of the virus throughout Indonesia. Interventions to prevent the spread of the HIV virus must be targeted not only to CSWs, but also to their clients. These interventions should include educational activities concerning AIDS and STD transmission and prevention, condom promotion, efforts to improve condom availability, and activities to strengthen the health sectors' STD diagnosis and treatment capabilities for both CSWs and their clients.
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PMID:AIDS knowledge and risk behaviors among domestic clients of female sex workers in Bali, Indonesia. 748 34

Ch7 (RGSDIAG), a synthetic heptapeptide derived from a conserved region of HIV p24 (aa 232-238), was previously shown to suppress antigen-induced responses in cultures of normal human peripheral blood lymphocytes (PBL). We show in this paper that Ch7 is the shortest peptide retaining full inhibitory capacity. Further, the peptide inhibited efficiently and in a dose-dependent manner the induction of a specific antibody response to the antigens SRC (sheep red cells) and Candida albicans but did not exert any effect on the induction of immunoglobulin-secreting cells in PWM-stimulated cultures. Finally, Ch7 inhibited anti-CD3-induced lymphoproliferation but did not affect anti-CD2 activation. These results suggest that a conserved epitope of HIV p24 may be able to prevent the induction of antigen-specific antibody responses by interfering with lymphocyte activation via the T3-Ti complex, resulting in the abrogation of immune functions that are defective in HIV-infected individuals.
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PMID:An HIV p24 heptapeptide down-regulates antigen-specific responses in vitro interfering at the level of the T3-Ti complex. 751 94

This article on false positive serological reactions for syphilis reviews the rapid developments which have taken place in the serodiagnosis of syphilis in recent years since the advent of the AIDS epidemic. An overview of non-specific and specific treponemal serological tests in relation to acute and chronic biological false positive reactions is followed by closer consideration of syphilis serology in the context of HIV infection, pregnancy and other conditions which may produce false positive reactions.
Int J STD AIDS
PMID:Are you sure it's syphilis? A review of false positive serology. 754 85


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