Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a prospective study to identify the viral type isolated from women undergoing screening for herpes simplex virus (HSV) during pregnancy using fluoroscine-labelled monoclonal antibodies to HSV-1 and HSV-2, HSV-2 was more likely to be isolated during the third trimester and was the only viral type isolated at term. As the severity of neonatal central nervous system disease is greater with HSV-2 than HSV-1 we recommended that all women with a history of genital herpes should be screened during pregnancy.
Int J STD AIDS
PMID:Screening pregnant women for genital herpes. 157 89

A restrospective survey of the notes of 146 patients with culture-positive first episode genital herpes simplex infection produced 37 men and 37 women in whom the incubation period could be established from their own and their partners' notes. In 9 patients the period was 1-12 days, in 20 men it ranged from 1 to 49 days and in 11 women from 1 to 28 days. In 7 patients it was much longer. In 28 patients a first episode of genital herpes developed during an ongoing monogamous relationship. These findings indicate that the incubation period of genital herpes may be longer than hitherto recognized and have implications for counselling and control.
Int J STD AIDS
PMID:Does first episode genital herpes have an incubation period? A clinical study. 191 62

In a retrospective clinical audit of patient records to determine the value of examining the sexual partners of women with initial genital herpes, it was evident that only the regular partners attended for screening. Twenty-six per cent of women with initial genital herpes and 19% of male partners had some form of other lower genital tract infection. Of 164 male partners of women with initial genital herpes, 30 (18.3%) also suffered from initial genital herpes at the same time, 22 (13.4%) gave a history of, or had signs consistent with, recurrent genital herpes, and 3 (1.8%) asymptomatic male partners without a previous history of genital ulceration had herpes simplex virus isolated from the urethra on routine screening.
Int J STD AIDS
PMID:Value of examining the sexual partners of women suffering from initial genital herpes. 195 23

In a study to determine the herpes simplex virus (HSV) type isolated from patients with primary (first-attack) genital herpes and to identify any clinical or epidemiological features that might influence the reported incidence of any particular viral type, there was almost an equal incidence of HSV-1 and HSV-2 isolated from women (48% versus 52%). In the case of women, the initial clinical diagnosis was correct in 97% with HSV-1 and 95% with HSV-2 infection. Amongst men, HSV-2 was isolated more frequently than HSV-1 (71% versus 29%). However, the initial clinical diagnosis in men was correct in only 53% with HSV-1 and 83% with HSV-2 infection. These results suggest that in primary genital herpes the incidence of HSV-1 and HSV-2 is probably equal, while in men the reported incidence of HSV-1 may be affected by underdiagnosis giving a falsely high incidence of HSV-2 infection.
Int J STD AIDS 1990 May
PMID:Incidence of herpes simplex virus type-1 and type-2 from patients with primary (first-attack) genital herpes in Sheffield. 196

A prospective study of the epidemiology, clinical aspects, and laboratory features of 1st episode genital herpes was conducted in Middle Road Hospital, Singapore between June 1986-December 1987. A total of 68 patients were studied and there were more women than men in the study population; the ratio of females:males was 7.5:1. The peak incidence of 1st episode genital herpes was between 20-29 years of age. Specimens from 63 patients yielded positive culture for herpes simplex virus (HSV). HSV-1 was isolated from 21 patients (30.9%), HSV-2 from 41 patients (60.3%), and untyped HSV from 1 patient (1.5%). True primary genital herpes was diagnosed in 43 patients (68.3%) using a test for complement fixing antibodies to HSV. HSV-1 was found to be the causative agent in 18 (41.9%) of the true primary infection, HSV-2 in 24 (55.8%), and untyped HSV in 1 (2.3%). In comparison, HSV-1 was isolated in only 2 (10%) of the 20 patients with nonprimary 1st episode genital herpes; HSV-2 was found in 13 patients (65%), and the culture was negative in 5 (25%).
Int J STD AIDS 1990 May
PMID:Clinical and laboratory study of first episode genital herpes in Singapore. 196 1

A total of 100 heterosexual adults of either sex with frequent episodes of recurrent genital herpes were allocated to treatment with either Genivir (DIP-253) 1% cream or placebo cream. All patients had genital herpes previously verified by a positive viral culture. The study was carried out as a double-blind parallel group trial. Fifty patients were allocated to each of the two treatment groups. The treatment was initiated within 24 hours after the first sign of a recurrence, and at the pretreatment examination all patients had developed typical lesions with blisters and/or sores. At baseline a sample for herpes virus culture and typing was obtained. The creams were applied four times daily for five days. Follow-up examinations were carried out on days 1, 2, 4 and if needed on days 7, 10 and 14. The major factor used for assessment of efficacy was the time to complete healing of all lesions. Duration of pruritus and pain were also recorded. In the group of patients treated with Genivir cream the time to complete healing was 3.3 days and in the placebo group 6.1 days. The difference was statistically significant (P less than 0.001). The mean duration of pain was 1.3 days in the Genivir group and 2.5 days in the placebo group: this difference also reached significance (P less than 0.01). The duration of pruritus was about the same in both groups. The active agent in Genivir, DIP-253, is a heterocyclic aromatic complex with confirmed anti-herpetic activity and with evidence of a local immunomodulatory effect. It was concluded that the efficacy of topical application of DIP-253 may be due to combined antiviral and immunomodulatory activities.
Int J STD AIDS 1990 Jan
PMID:Genivir (DIP-253) 1% cream versus placebo cream in the treatment of recurrent genital herpes: a double-blind study. 209 94

To evaluate the prevalence of symptomatic versus asymptomatic or unrecognized type 2 herpes simplex virus (HSV-2) infection, the authors performed physical examination, viral cultures, and type-specific serologic assays in 776 randomly selected women attending an STD clinic and 636 female university students. Forty-six percent of women attending the STD clinic compared with 8.8% of the university students had serologic evidence of HSV-2 infection. Clinical or historical evidence of genital herpes was present in only 34% of the HSV-2 seropositive women attending the STD clinic and in 29% of the HSV-2 seropositive women attending the university clinic. Among women attending the STD clinic, the prevalence of recognized genital infection was more common among those with HSV-2 antibodies only versus those with HSV-1 and -2 antibodies (odds ratio = 2.39; 95% confidence interval = 1.30-4.37), suggesting that HSV-1 infection reduces the likelihood of recognizing HSV-2 infection. In view of the high proportion of seropositive individuals with unrecognized HSV-2 infection in both high and low prevalence HSV-2 seropositive populations, newly developed HSV type-specific serologic methods should be evaluated for detecting carriers of HSV-2 infection and counseling these individuals about strategies for avoiding sexual and perinatal transmission of HSV-2.
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PMID:The frequency of unrecognized type 2 herpes simplex virus infection among women. Implications for the control of genital herpes. 216 15

During 1983-86, genital herpes (GH) was diagnosed in 225 (19%) of 1194 patients attending the STD clinic, attached to a Medical College in south India. The patients included 169 men and 56 women; 50 had primary GH and 175 had recurrent GH. The prevalence of GH in men and women did not differ significantly but the proportion of primary GH was significantly higher in women. There was no seasonal variation. The clinical epidemiology of these patients is compared with those in other countries. Virological confirmation of GH was obtained in 38 per cent of patients through culture and in a further 12 percent through serological tests. Papanicolaou smears were positive in 30 per cent men regardless of the type of GH, and in 38.5 and 7.1 per cent women with primary and recurrent GH, respectively. Cultures were positive for herpes simplex virus (HSV) in 38.7 per cent of patients with primary and 38.2 per cent with recurrent GH. Among the 52 viral isolates typed, nine of the 10 isolates from primary GH and all 42 from recurrent GH, were HSV-2. The geometric mean titres of antibody against HSV were higher in patients than in controls.
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PMID:Epidemiology & clinical profile of genital herpes. 278 86

In 589 males, 169 with and 420 without urethritis, urethral swabs were taken and assessed semiquantitatively for the sexually transmittable infectious agents Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma urealyticum, Mycoplasma hominis, Trichomonas vaginalis and Candida species. The organisms were isolated in patients with and without urethritis as follows: N. gonorrhoeae with urethritis 19.5%, without 0.0%; C. trachomatis with urethritis 16.0%, without 2.9%; U. urealyticum (high cfu-counts) with urethritis 27.2%, without 11.7%; M. hominis (high cfu) with 4.7%, without 2.9%. Combined infections were more frequent in males with urethritis (20.8%) than in those without (5.4%). None of the investigated pathogenic microorganisms could be demonstrated in 37.9% of males with and in 71.2% of males without urethritis. Using loglinear analysis, a significant coincidence of infections with N. gonorrhoeae and U. urealyticum and of infections with U. urealyticum and M. hominis was found. It is concluded that an asymptomatic infection of the male urethra with sexually transmittable organisms is to be expected in partner's control examinations and in patients presenting for other STD like venereal warts or genital herpes. Therefore in these men, even if they are asymptomatic, a comprehensive microbiological examination is strongly recommended.
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PMID:Sexually transmittable organisms in the urethra of males with and without urethritis. 311 95

We stand on the threshold of a new era for the STDs. The traditional STDs remain serious public health problems, particularly in the developing world, but they pale by comparison with AIDS. We can expect that the number of most STDs will decrease as the "baby boom" generation ages. We may also witness a change in sexual behavior caused in part by the fear of contracting AIDS, genital herpes, and perhaps other STDs. The challenge for the future is to improve control of chlamydial and gonococcal infections to prevent late sequellae such as infertility and ectopic pregnancy; to give greater attention to behavior modification to prevent transmission of AIDS, HSV, and HPV; to improve control of STDs in developing countries; to develop vaccines for the viral STDs, which are most difficult to cure; and to develop a better understanding of the mechanisms by which STD agents interact with each other and their host to cause cancer.
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PMID:Epidemiology of the sexually transmitted diseases. 387 48


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