Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)


Int J STD AIDS
PMID:Azithromycin (Sumamed-Pliva) in the treatment of chlamydial genital tract infections in infertile marriages. 133 73


Int J STD AIDS
PMID:Abnormalities of liver function during HIV seroconversion illness. 134 63


Int J STD AIDS
PMID:Cranial polyneuropathy and brainstem disorder at the time of seroconversion in HIV infection. 134 64

Since 1989, 21 persons with unexplained CD4+ T-lymphocyte depletion, but without evident human immunodeficiency virus (HIV) infection, have been described (1-12). These reports included persons who have resided in the United States and six other countries and who sought medical care for conditions often associated with immune deficiency. Some of these cases were also described at the VII International Conference on AIDS/III STD World Congress in Amsterdam. In addition, CDC has received reports of five persons from three states who have had persistently low CD4+ T-cell levels but who have had no evidence of HIV infection or underlying disease processes or therapies known to be associated with T-cell depletion. In some of these five patients, opportunistic infections were diagnosed that frequently occur in persons with acquired immunodeficiency syndrome (AIDS). This report describes preliminary clinical and laboratory findings from an ongoing investigation by CDC of these five patients.
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PMID:Unexplained CD4+ T-lymphocyte depletion in persons without evident HIV infection--United States. 135 46


Int J STD AIDS
PMID:Pancytopaenia and hepatosplenomegaly in an AIDS patient responding to high dose steroids. 136 59


Int J STD AIDS
PMID:AIDS and palliative care. 138 Mar 13

Haematospermia, blood in the ejaculate, is a symptom which provokes great anxiety in patients due to fears of malignant or sexually transmitted disease. However, there is no evidence from the published literature to associate it with any serious pathology. The large series of cases indicate that investigation is unproductive and that patients do not develop serious disease even after prolonged follow-up. Patients presenting with haematospermia warrant a full physical examination, including rectal examination, but in the absence of physical signs they should then be strongly reassured. Further investigation is unnecessary. Coexistent urological symptoms should be investigated appropriately.
Int J STD AIDS
PMID:Haematospermia. 847 63

Neonatal herpes simplex virus (HSV) infection is considered to be rare in the UK, affecting less than 3 per 100,000 live births, but the true incidence is probably higher due to under-reporting. In contrast, neonatal HSV infection is more common in the USA affecting 1 per 7500 live births overall. Infection in neonates is frequently serious and may be fatal.
Int J STD AIDS
PMID:Herpes simplex virus infection in pregnancy and its management. 842 9

Our knowledge concerning the pathogenesis of infection due to Haemophilus ducreyi is incomplete. In order to produce disease, H. ducreyi must presumably penetrate the skin of the external genitalia, colonize subcutaneous tissues, then produce tissue damage which results in ulcer formation. Penetration of the normal skin most likely occurs via minor abrasions. Adherence of H. ducreyi to different cell lines in vitro has been described, and might be mediated by adhesions such as pili or haemagglutinins. In addition, binding to extracellular matrix proteins has also been reported. Extracellular tissue-degrading enzymes were absent from broth culture supernatants of H. ducreyi. Such supernatants also failed to produce cytopathic effects with established or primary cell lines. Both live and heat-killed H. ducreyi organisms were able to produce lesions in a rabbit or a mouse model, although ulcer formation was dependent on viable H. ducreyi organisms in a recently introduced temperature-dependent rabbit model. With an excessive supply of iron, a more prolonged localized inflammatory disease effect was observed. Results derived from a subcutaneous chamber model demonstrated considerable changes in the expression of outer membrane proteins combined with antibody modulation during in vivo growth of H. ducreyi. These might be important factors for maintenance of infection in the human host particularly as these changes also occur in humans. Despite an increased knowledge of the pathogenesis of chancroid, important questions such as growth requirements, bubo-formation, role of cell-mediated immunity and ulcer formation are still unanswered. The application of molecular biological techniques in order to study these problems will be helpful.
Int J STD AIDS
PMID:Pathophysiological concept of Haemophilus ducreyi infection (chancroid) 139 Oct 58

A study was undertaken to assess the relationship between current cigarette smoking and genital infections. Four hundred women attending a sexually transmitted disease clinic were the subjects of the study; of these 212 (53%) were cigarette smokers. In women under 20 years of age 70% were smokers. Women who smoked were more likely to have multiple partners and be in a lower socio-economic class or unemployed. The presence of genital warts was commoner in smokers. No association was shown between smoking and cervical inflammation or dysplasia. The findings suggest that cigarette smoking is a behavioural factor which should routinely be identified in the demographic details of women attending sexually transmitted disease clinics.
Int J STD AIDS
PMID:Current smoking habits and genital infections in women. 842 8


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