Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.10.2 (
focal adhesion kinase
)
44,029
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
We recently reported that Rho guanine nucleotide exchange factor 10-like protein (
ARHGEF10L
) activated Rho GTPases as guanine nucleotide exchange factor to stimulate liver tumorigenesis. The present study continued to explore the effect of
ARHGEF10L
on the tumorigenic process of gastric cancer. This study detected increased expression of
ARHGEF10L
in GC tissues compared to peritumoral tissue samples. SGC7901 cells with
ARHGEF10L
overexpression showed increased cell proliferation, cell migration, and tube-like structure formation abilities, as well as increased expression of GTP-RhoA, ROCK1, and phospho-Ezrin/Radixin/Moesin.
ARHGEF10L
overexpression downregulated the expression of E-cadherin and upregulated the expression of N-cadherin and Slug, indicating an activation of
EMT
in the transfected cells. RNA-sequencing assay detected an increased expression of Heat shock 70 kDa protein 6 in the SGC7901 cells overexpressing
ARHGEF10L
. The above results suggest that
ARHGEF10L
expression can stimulate gastric tumorigenesis by prompting RhoA-ROCK1-phospho-ERM signaling, inducing
EMT
and increasing HSPA6 expression.
...
PMID:ARHGEF10L expression regulates cell proliferation and migration in gastric tumorigenesis. 3215 66
