Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective review of 51 secondary intraocular lens (IOL) implantations was made to determine the relative accuracy of the SRK regression formula and the refraction method described by Holladay in preoperative prediction of emmetropic IOL power. The regression formula accurately predicted emmetropia within 1 diopter (D) in 63% of patients; the refraction method accurately predicted within 1 D in only 26% of cases. The emmetropic power predicted by the two formulas differed by at least 1 D in 76% of patients. Precise measurement of preoperative variables is imperative to ensure accurate prediction of emmetropic IOL power in the patient considered for secondary implantation.
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PMID:Secondary IOL power calculations: a comparison of regression formula and refraction method in accurate prediction of emmetropia. 650 Oct 60

The accuracy of prediction of postoperative refractive error was evaluated in 175 patients with extracapsular cataract extraction and a Shearing-style posterior chamber intraocular lens. The Binkhorst, Colenbrander - Hoffer and SRK formulas were all less accurate in patients with an axial length greater than or equal to 24.5 mm. The standard error of the estimates of the Binkhorst formula was 1.2 diopters, the Colenbrander - Hoffer formula 1.18 diopters and the SRK formula 0.90 diopters. A new intraocular-lens formula for axial myopes was derived by polynomial regression analysis with a standard error of the estimate of 0.85 diopters. This new formula was accurate within 1 diopter in 79% of axial myopes compared to 71% for the SRK , 66% for the Colenbrander - Hoffer and 64% for the Binkhorst formulas. Regression analysis of a surgeon's own patient data can further improve the accuracy of prediction of the post-operative refraction.
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PMID:A new posterior chamber intraocular lens formula for axial myopes. 673 51

Sixty-five medical personnel thought to be exposed to hepatitis-B-surface antigen (HBs) positive material by accidental needle stick were treated with 4 ml hepatitis B-immunoglobulin (SRK, Swiss Red Cross). The prophylaxis was started as soon as possible, mostly within an hour or two. 56 patients were followed up with clinical and serological tests at monthly intervals for 9 months. In individuals exposed to HBs-antigen negative material, signs of HBV-infection could be detected only in one. In 36 cases potentially infectious material proved to be HBs-Ag positive. Six of the medical personnel (16.7%) had signs of hepatitis B-virus infection. One individual (2.8%) developed clinical hepatitis type B. Three (8.3%) converted to active hepatitis B markers (anti-HBs and/or anti-HBc) without clinical symptoms. Two of four who already had anti-HBs before exposure developed antibodies to HBc afresh at three- and six-month intervals. These serological conversions and the one case of clinical hepatitis developed despite the fact that HB-Ig was given in nearly all cases within one hour of exposure. The incubation period was 5-8 months. It is concluded that even rapid prophylaxis with HB-Ig after needle stick exposure does not afford 100% protection. It is urged that any passive prophylaxis with HB-Ig in exposed personnel should be complemented by active hepatitis B immunization.
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PMID:[Can prevention of hepatitis B following exposure to hepatitis virus be improved by immediate administration of HB immune serum?]. 687 37

The therapeutic effect of a polyvalent immunoglobulin preparation for intravenous use was tested in 82 newborns with bacterial infections. 35 of the children had neonatal sepsis, whereas in the other 47 bacteremia was not detectable. Treatment consisted either of antibiotics only or of antibiotics combined wih immunoglobulin SRK on an alternating basis for the first six days. Immunoglobulin substitution was tolerated without complications. In the group of infants with neonatal sepsis, two of 20 (10%) who were substituted with immunoglobulin and four of 15 (26%) who received no immunoglobulin died. Likewise, in the group of patients without detectable bacteremia, two of 21 on immunoglobulin substitution (10%) and four of the 26 who were not substituted (15%) died. The low mortality observed in the present study was attributed to efforts at early diagnosis and conventional early treatment on the one hand, and to immunoglobulin substitution on the other. To detect possible late sequelae of immunoglobulin therapy, particularly in hypogammaglobulinemic premature newborns, clinical and immunological investigations were performed in the septic patient group at the age of one to four years. There were no indications that administration of immunoglobulins during the neonatal period might have had an adverse effect on psychomotor and somatic development or on the immunological maturation of the infants.
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PMID:[Immunoglobulin substitution in the treatment of neonatal septicemia]. 730 48

The prediction accuracy of the Binkhorst, Colenbrander, and SRK formulas were compared in five series from different sources totalling 654 cases. The SRK formula was superior to both the other formulas by having a smaller average error per case, a smaller range of error from highest minus to highest plus, and a smaller proportion of cases with greater than 2 diopters (D) of error in all five series studied. In four of the five series, the SRK formula also had the greatest proportion of cases with less than 1 D of error. The Colenbrander formula was superior to the Binkhorst formula in all five series with regard to average error, proportion of cases with less than 1 D of error, and proportion of cases with more than 2 D of error. The range of error from highest minus to highest plus was equivalent with the two formulas. All available published literature on the accuracy of implant power prediction formulas was reviewed and appears to support our findings.
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PMID:Comparison of the accuracy of the Binkhorst, Colenbrander, and SRK implant power prediction formulas. 734 49

Comparison of results of intraocular lens implants with IOL powers obtained by Binkhorst and SRK Linear Regression formulae was done using various models and brands of intraocular lenses. Of 887 pseudophakic patients. 415 patients received IOL's with their powers calculated for planned emmetropia, by means of theoretic formula devised by R.D. Binkhorst and in the remaining 472 eyes the IOL power was calculated with the SRK Linear Regression method. No significant difference (P < 0.05) was found between visual acuities, obtained with IOL's alone or after postoperative overcorrection of residual refractive errors between the two groups.
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PMID:Comparison of intraocular lens power calculation using the Binkhorst and SRK formulae: a clinical study. 760 41

The accuracy of intraocular lens power calculation formulas for the axial high myopia were examined, especially regarding the point of the predictive refraction. We examined 170 eyes with axial lengths of 27 mm or longer, with postoperative visual acuity of 0.5 or more, and postoperative astigmatism of less than +/- 2D. Five formulas were tested for accuracy in predicting postoperative refraction. They were the L-SRK, SRK, SRK II, SRK/T, and Binkhorst formulas. The SRK formula tended to predict less myopia than the actual postoperative refraction. The SRK II and Binkhorst formulas predicted more myopia than the actual postoperative refraction. The best results were produced by the L-SRK and SRK/T formulas. The accuracy of the L-SRK formula predictions were measured for each of the four myopic levels. The same was done for the SRK/T formula. For both formulas, there was no statistically significant difference in accuracy of prediction for the four myopic categories. The two formulas are considered to be useful for high myopic cases.
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PMID:[An intraocular lens power calculation for high myopia]. 761 Oct 7

We studied the two-year postoperative course of 46 eyes with transscleral ciliary sulcus fixation of a posterior chamber intraocular lens (sutured group) and 30 eyes with ciliary sulcus insertion of a posterior chamber intraocular lens as a secondary implantation (nonsutured group). The following items were evaluated: visual acuity, difference between preoperative predicted refraction (calculated by the SRK II formula) and final postoperative refraction, complications, corneal endothelial cell loss, and anterior chamber depth. In the nonsutured group, visual acuity was favorable in general and few complications were observed. In the sutured group, 16 eyes were followed for 2 years, and 12 (75%) of them achieved the same or better visual acuity than before surgery. In 4 (25%) of them visual acuity decreased compared with its preoperative status. In the sutured group, we analyzed 13 factors that might have been associated with poor postoperative visual acuity, and cystoid macular edema appeared to be most strongly related with worse final visual acuity than before surgery (p < 0.05).
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PMID:[Postoperative course of transscleral ciliary sulcus fixation of posterior chamber intraocular lens and ciliary sulcus insertion of posterior chamber intraocular lens as a secondary implantation--postoperative long course of secondary intraocular lens implantation]. 766 Oct 44

In the Brassicaceae, self-vs. nonself-recognition in self-incompatibility is controlled by sporophytic S-alleles. Haplotypes specifying both SRK (S-receptor kinase) and SLG (S-locus glycoprotein) are considered to play an important role in the recognition reactions. We compared the nucleotide sequences of SRK9(Bc) and SRK6(Bo). The number of nonsynonymous substitutions per site (Pn) was lower, constrained, in the kinase than the receptor domain, while the numbers of synonymous substitutions (Ps) in the two domains were largely comparable. Pairwise values for Ps and Pn were calculated among 17 operational taxonomic units, including eight SLGs, the receptor domains of two SRKs, four SRAs (S-related A) and three SRBs (S-related B), which have high homologies with each other. The values of Ps and Pn of SLG were mostly comparable to those of the receptor domain of SRK. Dendrograms constructed on the basis of Pn and Ps indicated that SRA differentiated first, followed by SRB. The differentiation of SLG alleles is one of prerequisite factors for the establishment of self-incompatibility, and the allelic differentiation has occurred more than tens of million years ago.
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PMID:Evolutionary aspects of the S-related genes of the Brassica self-incompatibility system: synonymous and nonsynonymous base substitutions. 767 80

The accuracy of intraocular lens (IOL) power calculation was evaluated in a multicenter study of 822 IOL implantations using the Binkhorst II, Sanders/Retzlaff/Kraff (SRK I, SRK II, SRK/T), Holladay, and Olsen formulas. All but the first of these were optimized in retrospect with calculation of the SRK A-constant, the Holladay surgeon factor, and the Olsen pseudophakic anterior chamber depth (ACD) for each lens style. The ACD prediction of the Olsen formula was based on a previously described regression formula incorporating preoperative ACD, corneal height, axial length, and lens thickness. Among the optical IOL power calculation formulas, the highest IOL power prediction error was found with Binkhorst's and the lowest with Olsen's, which was more accurate than the SRK/T and the Holladay formulas (P < .05). The SRK/T formula was significantly more accurate than the original SRK regression formulas (P < .001). When analyzed for axial length dependence, all formulas showed the least error in the normal range. Error of the Olsen formula was lower than that of the others in the axial length interval 20 mm to 26 mm. No differences in accuracy were found between the optical IOL calculation formulas in eyes with an axial length above 26 mm (P < .05). The accuracy of IOL power calculation can be improved with optical formulas using newer-generation ACD-prediction algorithms.
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PMID:Intraocular lens power calculation with an improved anterior chamber depth prediction algorithm. 767 70


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