Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A template for intraocular lens (IOL) calculation and data manipulation designed for the Lotus 1-2-3 is presented. The template is menu-driven, providing automatic IOL calculation, form generation, and personal SRK generation for three IOL lens types as selected by the surgeon. Minimal computer skill and no programming knowledge is required. The template design is available without cost to ophthalmologists.
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PMID:A menu-driven Lotus 1-2-3 template for intraocular lens calculation and automatic generation of an SRK constant. 396

We examined the results of posterior chamber intraocular lens (IOL) implantation and evaluated six commonly used IOL power calculation formulas (original Binkhorst, modified Binkhorst, Colenbrander, Shammas, Hoffer, and SRK regression) to determine which ones produce the most accurate and predictable results. We found that the accuracy of the various formulas depends upon several factors, including the surgeon's technique, the type and style of posterior chamber IOL implanted, and the axial length of the eye being operated on. Furthermore, we found that the results using the different formulas vary in a consistent pattern. Surgeons must therefore evaluate their cases periodically to determine which formulas and IOL styles will provide their patients with the most accurate and satisfying results.
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PMID:Clinical evaluation of six intraocular lens calculation formulas. 398 12

We performed an analysis of ocular biometry and intraocular lens (IOL) power calculation on 100 eyes that had anterior chamber IOL implantation during 1981 and 1982. Various methods of calculating the IOL power were used, including the standard lens power, presurgical basic refraction, Fyodorov's formula, Colenbrander's formula, Binkhorst's formula, and the SRK formula. In addition, we took the median value of these calculated results as the median power in selecting an appropriate IOL power. The postoperative refraction and actually implanted IOL power were used to determine the IOL power needed for emmetropia. Our regression analysis of the predicted IOL power and power actually needed for emmetropia showed that the methods of standard power and presurgical basic refraction were unreliable while the rest were of satisfactory accuracy. Among the latter, all the predicted IOL powers based on the biometric data had almost the same coefficient of determination and standard error of estimate. However, with the SRK formula and the median power the values of the regression line were closest to the ideal value. With the regression analysis, the accuracy of predicted IOL power from theoretical formulas was comparable to that of the SRK regression formula.
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PMID:Analysis of intraocular lens power calculation. 400 14

The differences were studied between retrospectively calculated emmetropizing intraocular lenses and lenses estimated from different methods and formulas, either with or without the use of ultrasonic biometry. A number of 201 eyes was involved. The results show that ultrasonic biometry is an indispensable tool for the prediction of the power of intraocular lenses, which would produce emmetropia. The best results were obtained when using biometry and the simple empirical SRK formula.
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PMID:Intraocular lens power calculations: the optimal approach. 405 63

Mathematical error analysis shows that the prognosis of IOL powers on the basis of theoretical optical formulas for calculating lens power is no more accurate than the regression (SRK) formula. The minimum error in a recommended lens power is at present between +/- 0.6 and +/- 1.0 D. As a result of this range of error there is a range of equivalence of the two formulas, and the vast majority of cataract patients (85%) are within this range. However, in hyperopic eyes the SRK formula is clearly superior to the theoretical optical formulas for a clinically useful prognosis.
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PMID:[Equivalency of different methods of measuring lens power]. 406 76

In two of four non-enzymatically treated gamma-globulin preparations C Immunoglobulin Schura, Immunoglobulin SRK), the distribution of IgG subclasses was found to be close to that of normal human serum. In two other preparations (sulphonated and beta-propiolactone-treated) IgG3 was not detectable by means of appropriate antiserum. The IgG residual portion of plasmin-treated gamma-globulin was enriched in IgG2, while IgG3 was absent. In affinity chromatography on protein A Sepharose, IgG3 in the unbound and IgG1, IgG2 and IgG4 in the bound fractions were found in Immunoglobulins Schura and SRK. In the sulphonated preparation no IgG was found in the unbound fraction, while IgG1, IgG2 and IgG4 were eluted from the bound fraction. In beta-propiolactone-treated gamma-globulin IgG1, IgG2 and IgG4 were present in both fractions. The testing of reactivity of IgG subclasses with Staphylococcus protein A can supply important information about the state of the Fc part in immunoglobulin preparations.
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PMID:IgG subclasses in human gamma-globulin preparations for intravenous use and their reactivity with staphylococcus protein A. 615 36

In childhood approximately 90% of all idiopathic thrombocytopenic purpuras (ITP) are acute while in adults the majority is chronic (6 months duration). 0,5 - 1% of the children with ITP die. Conventional treatment comprises corticosteroids and, for chronic ITP, splenectomy and/or cytostatic immunosuppression. Inspired by the disappearance, during substitution, of concomitant ITP in 2 agammaglobulinemic boys, 13 children with ITP (3 chronic, 4 intermittent, 6 acute) were treated with high-dose intravenous immunoglobulin SRK. All responded favorably but one boy with chronic ITP became resistant after 11 months of infusions. F(ab')2 fragments are inactive. High doses of immunoglobulin could block Fc receptors of macrophages. They could also facilitate the formation and elimination of immune complexes and, indirectly, prevent the accumulation of platelet-associated immunoglobulin.
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PMID:[High-dose immunoglobulin infusions in idiopathic thrombopenic purpura]. 622 98

The functional antibacterial activity of an intravenous immunoglobulin preparation (Swiss Red Cross Immunoglobulin, SRK-Ig) was tested both in vitro and in vivo. Using type III group B streptococci as a model system, the intravenous immunoglobulin preparation was shown to enhance phagocytosis and killing of the bacteria by human neutrophils. There was good activity to several type III strains, and for efficient opsonization both antibody and complement were required. In an animal model of neonatal group B streptococcal sepsis, passively administered immunoglobulin enhanced survival with 27/37 (73%) treated animals surviving compared to only 3/16 (19%) controls. These studies demonstrate that the intravenous immunoglobulin preparation SRK-Ig has retained functional activity and may have potential value for prophylaxis or therapy of certain bacteria infections.
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PMID:Functional antibacterial activity of a human intravenous immunoglobulin preparation: in vitro and in vivo studies. 634 30

IgG-SRK (identical with Sandoglobulin) is a polyvalent IgG concentrate obtained by modified alcohol cryoprecipitation, including mild acidification at pH 4. This product was given in high doses intravenously for the treatment of six children with acute ITP, four children with intermittent ITP, and three children with severe chronic idiopathic thrombocytopenic purpura (ITP). An impressive initial response was observed in all patients, the extent of which may be of prognostic significance in acute ITP. Maintenance therapy was required in two of six patients with acute ITP, in three out of four patients with intermittent ITP, and in all of the patients with severe chronic ITP. In the cases of severe chronic ITP, the disease could not be adequately controlled over long periods of time, but bleeding episodes subsided or became considerably less frequent. Although little is known of the effects of IgG-SRK, possible mechanisms were discussed. It is emphasized that a new model has been discovered to study the interrelations between structure and function of human immunoglobulin molecules.
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PMID:Intravenous immunoglobulin for idiopathic thrombocytopenic purpura (ITP) in childhood. 643 40

15 patients with different forms of relevant antibody deficiency syndromes were treated with gammaglobulin (Immunglobulin SRK) by intravenous route. Analysis of the complement system showed a weak activation of the C-system in vivo and a reduction of C-turnover. Prior to infusions C-turnover seemed to be increased pathoogically. In response to infusions a significant increase in immune complexes or immune complex-like material could be demonstrated, partly caused by "real" antigen-antibody-reactions and partly by the in vivo action of gammaglobulin aggregates. These "induced" immune complexes may have immunomodulatory effects. Three patients developed anaphylactic reactions to gammaglobulin. In one patient these were associated with a classical antigen-antibody reaction and complement activation, and in a second patient with a questionable antigen-antibody reaction and complement activation. A third patient had an anaphylactic reaction without any of these signs.
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PMID:[Intravenous gamma globulin therapy. Measurement of circulating immune complexes and complement factors]. 647 19


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