Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.10.2 (focal adhesion kinase)
44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Two hundred and two consecutive intraocular lens (IOL) implantations, the lens power being predicted with the SRK-method, are retrospectively analyzed, and the factors possibly influencing the error in IOL power prediction are evaluated. The actual post-operative refraction is compared to the expected refraction for each IOL and to a hypothetical refraction that would have been obtained by a standard-power IOL implant. Axial length measurement and a high pre- and post-operative astigmatic error, along with low- and high power IOL predictions, are the factors that most influence the post-operative refractive error. A similar distribution of post-operative refraction could have been obtained by using a standard-power IOL instead of pre-operative calculation.
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PMID:Intraocular lens power calculation. A retrospective analysis of its practical value. 277 41

We give a precise theoretical formula used to calculate the power of implants. A spatial representation is shown. It exhibits Dc (power of the cornea) and l (axial length) values which induce a good fit between the power of artificial lens deduced from theoretical and statistical (S.R.K.) formulae. These values are situated on a look like parabolic curve (C) centered on a 26.13 mm or 27.2 mm l value according to anterior or posterior implants. We show the existence of area of (Dc, l) points giving a fit between theory and statistic within a given uncertainty delta DI. This fit is depicted on a chart (Dc, l, delta DI) on which the different curves which correspond to various delta DI, are deduced from the curve of equal power (C) by single translations. We indicate that an uncertainty near 1 dioptre on the power of the cornea induces a deviation near 0.21 dioptre on the powers of the anterior implant when calculated using the two methods. Moreover, we establish that the power SRK is always higher than the theoretical power for axial lengths situated in the 24 to 28.5 mm range.
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PMID:[Correlation intervals between the power values of artificial lenses deduced from theoretical formulae and regression formulae]. 279 52

In 1984, I reported that the refraction constant used in the SRK formula was too high and should have a value of 1.0 or less. The term refraction factor (RF) was adopted to replace the refraction constant which was under scrutiny. The current study was done in four phases. Phase 1 showed improved refraction prediction accuracy for sulcus-fixated intraocular lenses (IOLs) when an RF of less than or equal to 1.0 was used instead of a fixed RF of 1.25. The anterior chamber IOLs had worse results under the same conditions. Phase 2 retrospectively determined computer optimized and matched A constant and RF pairs for anterior chamber, sulcus-fixated, and bag-fixated IOLs for all axial lengths (AL), short (AL less than or equal to 21.5 mm), long (AL greater than or equal to 24.5 mm), and mid-range (21.5 mm less than AL less than 24.5 mm). Phase 3 demonstrated a dramatic improvement in the refraction prediction accuracy when the matched pairs according to AL were used in 61 consecutive patients receiving Jaffe, bag-fixated IOLs. Phase 4 demonstrated good results in 15 consecutive patients, using the RF found for Jaffe IOLs in calculations for a meniscus-type, bag-fixated IOL, with which I had no experience. I determined that the longer the eye, the smaller the RF, for any given IOL position in the eye. The data indicated that different RFs should be used for different IOL locations within the eye. The more forward the IOL, the larger the RF.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Using the intraocular lens refraction factor to improve refractive prediction accuracy. 232 91

A retrospective survey of 612 eyes that had undergone cataract extraction and IOL implantation was undertaken to evaluate the accuracy of ultrasound biometry combined with keratometry using the SRK regression formula, for the preoperative prediction of intraocular lens powers. A mean error of +0.35 dioptre sphere (DS) (SD +/- 0.98) was found for the series overall, with a significant (P less than 0.005) difference between the distribution of postoperative refractive errors using the S.R.K. formula for IOL prediction and the use of a standard lens of 19.5 DS. The consistency of results was tested for those patients with greater or less than normal axial length. Linear regression analysis showed no correlation between axial length and postoperative refractive error and therefore does not support the adjustment of predicted IOL powers by a factor based on axial length. Statistically significant differences were found between surgeons' results, supporting the practice of A-constant modification for individual surgeons.
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PMID:IOL prediction: an evaluation of preoperatively determined intraocular lens power accuracy. 305 21

Von Willebrand's disease (vWD), one of the most frequent hereditary bleeding disorders, is associated with a deficiency or a defective structure of von Willebrand factor (vWF). The defect is transmitted by autosomal inheritance. vWF is a plasma glycoprotein which mediates platelet adherence to the subendothelium of the injured blood vessel and is thus indispensable for primary hemostasis. vWF is composed of identical subunits linked together by disulfide bridges. Each subunit contains binding site(s) for factor VIII, collagen and platelets. The highly polymeric vWF factor is the largest known plasma protein. Functional activity is preferentially associated with the largest multimeric forms of vWF. Binding of vWF onto collagen fibrils activates its platelet binding sites, which are apparently not accessible in circulating vWF. Aggregation of washed fixed platelets in the presence of ristocetin or collagen is used for assessment of vWF's biological activity. Important additional information for the diagnosis of vWD is provided by the antigen assay and by electrophoretic analysis of the multimeric pattern of vWF. In type I vWD, all polymeric forms of vWF are reduced in the same proportion, while only the largest, i.e. the most active, multimers are deficient in type II vWD. The most severe type III vWD is characterized by an undetectable concentration of vWF. DDAVP corrects the prolonged bleeding time in patients with mild forms of vWD. Cryoprecipitate or "virus inactivated" factor VIII concentrates are employed for substitution therapy. Our results suggest that the newly introduced "virus inactivated" factor VIII concentrate from SRK is likewise suitable for this purpose.
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PMID:[Von Willebrand's disease]. 312 18

Accurate intraocular lens power calculation is an important adjunct to the technique of extracapsular cataract extraction. An increasing number of ophthalmologists now perform preoperative biometry routinely. We studied a group of fifty patients and analysed the accuracy of intraocular lens power calculation using the SRK formula.
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PMID:Intraocular lens power calculation. 325 28

Intraocular lens power prediction and final astigmatism were evaluated in 100 consecutive cataract patients (age 57-92 years, mainly with intracapsular extraction) 4-13 months after insertion of a 3M type 78 anterior chamber lens. The analysis was based on refractive recordings from the referring ophthalmologists who took care of post-operative controls. Ninety-two patients were accepted for the study. A Sonometrics DBR 400 ultrasound equipment and a Haag-Streit keratometer had been used for measuring eye length and corneal power, the Binkhorst programme and SRK formula for selecting IOL power, resulting in an IOL range of +12 to +23 D. Mainly, low myopia was intended. Nearly 50% fell within 0.5 D from predicted value; 90% were within +/- 1.5 D, by both calculating methods. SRK predictions appeared unaffected by eye size, while axial length (x) significantly influenced Binkhorst prediction (y): y = 8.08-0.35x (r = -0.40), the deviation being most marked in very short eyes. For eyes of midsize the two methods did not differ. Regarding astigmatism, 3 patients ended with values above 3D. In 83% it was less than 2D. Eighty per cent obtained a visual acuity of 0.5 or better. All things considered we feel that the calculation procedure should be standard when performing cataract surgery with IOL implantation.
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PMID:Intraocular lens calculation. An evaluation of Binkhorst and SRK estimates in 100 consecutive cataract extractions with 3M type 78 anterior chamber lens implantation. 332 76

Calculations were made comparing a variety of formulas in patients who required unusually high and low power intraocular lenses. Of the formulas tested, the author found the Colenbrander formula to be more accurate for myopic patients and the SRK formula to be more accurate for hyperopic patients.
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PMID:Reliability of lens implant power formulas in hyperopes and myopes. 334 Mar 97

A simple modification of the SRK formula was developed for use with extreme axial length cases (short and long eyes) to maximize prediction accuracy in these groups. For "average" eyes (over 75% of all cases), SRK needed no modifications to maintain maximum predictive accuracy. The new, modified SRK formula (SRK II) was compared with current second generation formulas and the Binkhorst formula. The SRK II formula, while maintaining the simplicity and ease of the SRK, was comparable to and in some cases superior to the other formulas. Overall, 80.0% of 2,068 posterior chamber intraocular lenses from seven different manufacturers demonstrated less than one diopter of prediction error and only 0.5% had three or more diopters of error. In short eyes (less than 22 mm), 74.0% were corrected to within one diopter and less than 2.0% had three or more diopters of error. In long eyes (greater than or equal to 24.5 mm), 78.0% of cases demonstrated less than one diopter of error and less than 1.0% had three or more diopters of error. Although the SRK II formula is incorporated in most new A-scan units, the modifications are so simple that surgeons can take the standard SRK predictions and mentally calculate the modifications for extreme cases.
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PMID:Comparison of the SRK II formula and other second generation formulas. 335 49

We evaluated aphakia and pseudophakia in highly myopic patients whose axial lengths were 27 mm and over. Cataract surgery alone was performed on 99 eyes (aphakic group) and intraocular lens (IOL) implantation was performed on 84 eyes (pseudophakic group). The IOL power was determined by the SRK formula and ranged from +9.0 to +18.5 diopters (D). There was no statistical difference in postoperative complications between the aphakic and pseudophakic groups. The postoperative aphakic refractions ranged from +9.5 D to -3.5 D, and the pseudophakic refractions, from +2.5 D to -14.0 D. A visual acuity of 20/40 or better was achieved by 51% of aphakic patients and 63% of pseudophakic patients. A near visual acuity of 20/40 or better was achieved by 65% of pseudophakic patients. Seventy-three pseudophakic eyes (87%) were not corrected or were corrected with minus diopter lenses. This confirmed our opinion that there was no need to correct them for near vision. According to a postoperative questionnaire, 67% of the pseudophakic patients did not need spectacles for near vision and 93% of patients could see comfortably for daily life. In view of these results, we feel that most myopic patients are good candidates for IOL implantation.
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PMID:Intraocular lens implantation and high myopia. 340 24


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