Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.10.2 (focal adhesion kinase)
44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Many second generation intraocular lens power calculation formulas have recently been introduced. This study explores the performance of these formulas while controlling for a potential source of variation--the lens type. For this study, all 1,157 cases studied used the Cilco CPLU posterior chamber lens. All surgeries were performed using similar phacoemulsification techniques by only two physicians (R.M.C. and S.C.G.). The SRK, SRK II, Holladay, and Binkhorst formulas were compared among themselves and also with a piece-wise nonlinear regression formula ("best fit") developed specifically from these data by the authors. Performance of the SRK II, Holladay, and best fit were better than the older SRK and Binkhorst for most axial length ranges. For these data, the Holladay and best fit formulas performed marginally better overall than the other formulas. It was also found that manipulation of specific surgeon constants significantly affected the performance of the Binkhorst formula, but had little effect on the other formulas.
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PMID:Intraocular lens implant power calculations: investigations controlling for lens type. 238 Sep 26

The refractive outcome in 44 eyes that had combined penetrating keratoplasty and intraocular lens insertion, with at least 6 months follow-up, was analyzed. All patients were operated on by the same surgeon using two types of trephines in all but one eye, and one suturing technique with nylon or dacron sutures. The intraocular lens power was calculated using SRK II formula with an assumed average post-operative keratometry of 45 D. The first refraction showed that the mean spherical equivalent was -0.20 +/- 3.45 D, the mean refractive astigmatism was 5.11 +/- 2.48 D and the average keratometry had a mean of 44.42 +/- 3.19 D. Modulation of postoperative astigmatism was done by selective removal of tight interrupted sutures, taking out one suture or maximally two sutures per visit, based on refraction, keratometry, and keratography criteria. The total number of sutures removed had a mean of 2.5 +/- 2.2 with a mean total number of visits of 5.3 +/- 2.0. The interval between visits had a mean of 4.5 +/- 1.9 weeks and the total duration of the suture removal phase was about six months. At the end of the refractive rehabilitation period, 73% of cases had a spherical equivalent between +3.0 D and -3.0 D and 61% of cases had an average keratometry within 2.5 D from our assumed value of 45 D. The mean postoperative refractive astigmatism was 2.5 +/- 1.5; 55% of cases had 3.0 D or less of astigmatic error and 90% of cases were within 4.0 D of postoperative astigmatism.
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PMID:Refractive results of successful penetrating keratoplasty, intraocular lens implantation with selective suture removal. 248 11

Twenty-one consecutive triple procedures (keratoplasty, cataract extraction, lens implantation) performed by one surgeon using identical suturing technique, donor size, and donor/recipient size disparity were analyzed for visual outcome and refractive error. Ninety-five percent of all grafts were clear with an average follow-up of 11.8 months. Of patients with good preoperative visual potential, 84% achieved 20/40 or better visual acuity, and the majority of these patients obtained 20/40 acuity within 6 months of surgery. Sixty-three percent of eyes with 20/40 or better acuity had refractions within +/- 2 diopters of the predicted post-operative refraction. The most recent 14 eyes in this series had IOL power calculations performed utilizing the SRK regression formula and 43.00 K's (surgeon's average post-keratoplasty keratometry values). Within this group, 79% achieved 20/40 or better vision. Eighty-two percent of these eyes had refractions within +/- 2 diopters, and 100% were within +/- 3 diopters of the predicted value. These findings demonstrate that a single surgeon using standardized keratoplasty can achieve good refractive results in the triple procedure.
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PMID:The effect of standardized keratoplasty technique on IOL power calculation for the triple procedure. 255 54

Four patients underwent cataract extraction with posterior chamber lens implantation several years after radial keratotomy. All four patients experienced an initial hyperopic shift caused by an early postoperative corneal flattening of greater than or equal to 1 diopter. This flattening partially regressed, leaving the patients with a mean of 0.42 diopter of persistent corneal flattening. We found the Binkhorst and the Holladay intraocular lens calculation formulas to be more accurate than the SRK II for these patients. Corneal curvature measured with the keratometer was less accurate for intraocular lens calculations than was a value derived by subtracting the refractive change induced by the radial keratotomy from the patients' keratometric measurements obtained before radial keratotomy.
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PMID:Refractive complications of cataract surgery after radial keratotomy. 259 47

The error in prediction of emmetropic intraocular lens power or postoperative refractive error after lens implantation was analyzed in three groups of eyes after posterior chamber lens implantation. Regression line calculation with the SRK equation or with a group-specific regression was compared with theoretical calculations in unselected, long myopic and short hyperopic eyes. The cut-off length was below 22.0 mm for the short eyes and above 25.9 mm for the long eyes. In the unselected and hyperopic group, there was only a small difference in mean error and error variance when the three calculation methods were compared. In the high myopic group, the range of error increased in all methods. The worst results were obtained with the standard SRK equation because the slope of the regression line in myopic eyes differs from the classical regression line calculated on an average population of implants. Lens calculation in high myopic eyes should therefore be performed with a specific regression line or by theoretical calculation.
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PMID:Effectiveness of intraocular lens calculation in high ametropia. 235 33

We developed a formula suitable for calculating intraocular lens power for eyes with axial lengths of 27 mm or greater. We then used this formula in a prospective study to determine its reliability in 32 eyes. In these latter cases the mean error between predictive postoperative refraction and actual postoperative refraction was 0.36 D, with 67% of the cases having less than 1.0 D error; 84% of the cases having less than a 2.0 D error; and no cases having an error greater than 3.0 D. The new formula provided greater accuracy for these highly myopic eyes than the SRK, SRKII, Hollady, and Thompson formulas.
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PMID:A new intraocular lens formula for high myopia. 263 Sep 66

In order to determine the power of intraocular lenses more easily prior to cataract surgery, we compared the results obtained by automatic measurement of the corneal refractive power by the Humphrey Autokeratometer with manually obtained measurements using the Zeiss ophthalmometer. Similarly, the axial length was determined by automatic measurements using the Digital B System IV (Cooper Vision) and manual measurements using the Ophthascan S (Biophysic Medical). Statistical evaluation showed that there were no significant differences in the corneal refractive power determined by the two methods or in the IOL power calculated using the SRK formula. Therefore, automatic measurement of both corneal refractive power and axial length following the above method can be a useful alternative to the preoperative determination of the IOL power.
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PMID:[Automatic biometry and keratometry in comparison with the manual technic]. 266 73

The contact technique for ultrasound biometry was compared to the immersion technique. One hundred eyes were measured by both methods. Two groups were created based upon the axial length measurement: a group of 46 short eyes (axial length less than 23.3 mm) and a group of 54 long eyes (axial length greater than 23.3 mm). In each group the different types of measurement influenced the results obtained for the anterior chamber depth and the axial length of these eyes such that the contact technique yielded shorter measuring values than the immersion technique. In considering both methods, the difference in the anterior chamber depth and the axial length was smaller in the first group. Shorter measurements produced stronger intraocular lens power, which is equivalent to the axial length shortening by using the contact technique. The effect on the implant power calculation and the postoperative deviation of the pseudophakos refraction is shown by comparing the theoretical formula with the SRK formula. This prospective study describes the greater range of refractive pseudophakos deviation when using the contact method.
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PMID:Comparison of contact and immersion techniques for axial length measurement and implant power calculation. 267 12

Assessment of intraocular lens (IOL) power may rely, when biometric measurements of the eye are not available, on refraction previous to cataract development. Such an assessment, however, is generally considered unreliable. To improve the predictability of this method, we correlated refraction measurements with predictions of IOL power. In contrast to previous studies which used retrospective assessment of precataract refraction, this study included only noncataractous eyes and correlated the direct refractive measurements obtained with hypothetical IOL power values. These values were calculated by placing axial length and corneal power measurements of the same eyes in the SRK formula. We conclude that the regression formula obtained may improve the clinical judgment required for predicting lens implant power in cataractous eyes, on the basis of precataract refractive measurements.
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PMID:Assessment of intraocular lens power on the basis of precataract refractive measurements. 267 13

The purpose of this study is to appreciate post-operative ametropia in pseudophakic patients (EEC and posterior chamber IOL). Two groups were implanted either with a standard 21 D IOL (group 1) or after calculation of implant power according to the SRK formula (group 2). Results show residual refractive errors over 2 D in 7% of case in group 2 and 22.3% of case in group 1.
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PMID:[Validity of prediction after standard implant and the implant calculated according to the SRK formula]. 276 Apr 7


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