Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A series of 90 eyes of 88 myopic patients who underwent extracapsular cataract surgery with intraocular lens implants (IOLs) between 1984 and 1989 were analysed in a retrospective study. The axial length as obtained by ultrasonic A scan and keratometry readings were applied to the SRK1 and modified SRK (SRK2) formulae and the result compared with the actual post-operative state achieved.
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PMID:An analysis of the accuracy of prediction of intraocular implant power in the myopic patient. 206 Jun 73

The preoperative and postoperative influence of different parameters on the predictability of formulas used for intraocular lens (IOL) power calculation (axial length, corneal dioptric power, IOL malposition, postoperative astigmatism) has been shown by various authors. In this study, we evaluated the preoperative astigmatic influence on the prediction of postoperative refraction in eyes operated on for cataract with IOL implantation. Three hundred and fifty-nine eyes were evaluated after cataract surgery and IOL implantation. We calculated predictive errors of both the Binkhorst and SRK formulas for each eye. Based on the outcome of the predictive errors we divided the eyes into six groups: three of high and three of low predictability. Preoperative astigmatism in these groups was statistically compared (using the Student's t-test). The preoperative astigmatism was always higher in the group with low predictability than in the group with high predictability (P less than .05).
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PMID:Preoperative astigmatic influence on the predictability of intraocular lens power calculation. 223 75

The anterior chamber depth was measured in 15 eyes with sulcus placed (Group 1) and 12 eyes with bag placed (Group 2) IOGEL PC-12 lenses, and in 11 eyes with bag placed IOGEL 1103 lenses (Group 3). The mean anterior chamber depth was 3.29 mm in Group 1, 4.17 mm in Group 2, and 4.16 mm in Group 3. The difference between the mean anterior chamber depth with sulcus and bag placed IOGEL PC-12 lenses is statistically significant (P less than .0005). One effect of the different anterior chamber depths was that the anterior surface of a sulcus placed IOGEL lens frequently touched the pupillary border, whereas this rarely occurred when it was placed in the capsular bag. Another effect of differing anterior chamber depths was a different A-constant for the SRK-formula for sulcus or bag placement. In this study it was about 1 diopter greater with bag fixation than with sulcus fixation. It is recommended that each surgeon use specific A-constants to enhance the predictability of the postoperative refraction.
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PMID:Anterior chamber depth with sulcus and capsular bag placed IOGEL lenses. 225 10

Analytical predictions of primary implant power using presumptive errors in keratometer and axial length measurements were performed using the modified Binkhorst, modified Colenbrander, Holladay, Hoffer, and SRK II equations. These predictions demonstrate that the contributions to primary implant power error resulting from inaccurate axial length and keratometer measurements are algebraically additive. In eyes with a normal axial length, the resulting implant power determination error can be larger than differences in implant power prediction among these five IOL equations. Calculations using measurement errors of 0.2 mm in axial length and 0.50 diopter (D) in corneal curvature predicted a worst case primary implant power error of +/- 1.17 D. These calculations were performed using an axial length and corneal curvature near the population mean. In contrast, implant equation variability was determined to be +/- 0.19 D by calculating the standard deviation of the five implant power formulas with the measurement errors set to zero. Implant power prediction errors were increased when a flat cornea was paired with an axial hyperopic or an axial myopic eye. These combinations maximize the implant power error resulting from both implant formula variation and inaccurate measurements. Primary implant power error prediction tables are presented for emmetropic, axial hyperopic, and axial myopic eyes, as a function of presumed errors in axial length and corneal curvature. These error predictions clearly show that inaccuracy in axial length measurements and keratometer readings can be first order determinants of postoperative spherical refractive error.
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PMID:Effect of keratometer and axial length measurement errors on primary implant power calculations. 229 77

We compared the accuracy of the Holladay and SRK II intraocular lens power calculation formulas with that of two commonly used formulas, the Binkhorst and SRK. We found no significant difference between the accuracy of the four formulas in cases of posterior chamber lens implantation. For anterior chamber lenses, the SRK II formula was significantly less accurate than the other three formulas in eyes with long axial length.
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PMID:Clinical evaluation of the Holladay and SRK II formulas. 229 78

The predictability of a theoretical, computerized (PC-assisted) intraocular lens (IOL) power calculation method and of the Sanders-Retzlaff-Kraff [SRK] I and II methods was evaluated from preoperative and postoperative biometry in 202 cataractous patients who had extracapsular cataract extraction (ECCE). The theoretical method resulted in the lowest range and standard deviation of the error, and the highest correlation coefficient between the observed and the predicted refraction (P less than .05). The superiority of the theoretical approach was most clearly demonstrated when the postoperative measurements were used in the predictions (P less than .001). This demonstrated the potential accuracy of the formula used and the importance of incorporating methods to predict the IOL position after surgery. If the prediction of the IOL chamber depth was properly corrected for the axial length dependence, a high prediction accuracy could be obtained in short as well as in long eyes.
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PMID:Theoretical versus SRK I and SRK II calculation of intraocular lens power. 232 81

After previous assessment of the dioptric potency (by means of a SRK formula) the authors implanted the appropriate intraocular lenses. After 4-18 months following implantation the calculated refraction calculated before the intervention was compared with the postoperative reality. In 85% the difference was not greater than +/- 1.5 Dsf. The calculation of aniseiconia was made only in case of preoperative ametropia greater than +/- 2 Dsf.
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PMID:[Comparison of the predicted and actual refraction of the eye after intraocular lens implantation]. 233 90

A new implant power calculation formula (SRK/T) was developed using the nonlinear terms of the theoretical formulas as its foundation but empirical regression methodology for optimization. Postoperative anterior chamber depth prediction, retinal thickness axial length correction, and corneal refractive index were systematically and interactively optimized using an iterative process on five data sets consisting of 1,677 posterior chamber lens cases. The new SRK/T formula performed slightly better than the Holladay, SRK II, Binkhorst, and Hoffer formulas, which was the expected result as any formula performs superiorly with the data from which it was derived. Comparative accuracy of this formula upon independent data sets is addressed in a follow-up report. The formula derived provides a primarily theoretical approach under the SRK umbrella of formulas and has the added advantage of being calculable using either SRK A-constants that have been empirically derived over the last nine years or using anterior chamber depth estimates.
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PMID:Development of the SRK/T intraocular lens implant power calculation formula. 850 49

We compared the predictive accuracy of the SRK/T formula to the SRK II, Binkhorst II, Hoffer, and Holladay formulas in seven series of cases totaling 1,050 eyes. In the combined group, the SRK/T and Holladay formulas performed only slightly better than the other formulas. In short eyes (less than 22 mm), all formulas performed well, with the SRK/T, SRK II, and Holladay formulas performing marginally better. In moderately long eyes (greater than 24.5 mm, less than or equal to 27 mm), the Hoffer and Binkhorst II formulas had a greater proportion of cases with greater than 2 diopters (D) of error and the SRK/T and Holladay were again marginally better. In the very long eyes (greater than 27 mm and less than or equal to 28.4 mm), there were only 11 cases and all formulas performed well since none had greater than 2 D of prediction error. In an extremely long eye data set (greater than 28.4 mm), the SRK II formula clearly gave the poorest result. Eyes of this length occurred in only 0.1% of cases in our unselected series. Results support the contention that the present second and third generation IOL power formulas give fairly equivalent accuracy. Other factors, such as availability, ease of use, and ability to tailor or individualize, become major considerations.
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PMID:Comparison of the SRK/T formula and other theoretical and regression formulas. 235 22

We describe our modification of the most accurate intraocular lens power calculation formula currently used, the SRK formula, to improve the accuracy with which it can be used to calculate the power of IOLs that are implanted in severely myopic eyes, especially in those with exceptional axial length. This modified formula, which we call the L-SRK, is I = A - 2.5 L - 0.9 K - 1.69R - 1.69 (where I = the actual implanted IOL power; A = the A-constant; L = the axial length; K = the average keratometer reading; and R = the predicted postoperative refraction). The results achieved using this modified formula demonstrate its superior accuracy in calculating lens powers for severely myopic eyes.
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PMID:A simple modified SRK formula for severely myopic eyes. 236 53


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