Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.2 (focal adhesion kinase)
 44,029 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Five methods for predicting pseudophakic anterior chamber depth (ACD) by five previously described intraocular lens power calculation formulas (Binkhorst II, Lepper and Trier, Holladay et al., Sanders-Retzlaff-Kraff (SRK/T), Olsen et al.) were evaluated in a series of 640 patients with a posterior chamber lens implant. Significant differences in formula performance were found in unusually short and long eyes. High errors were found in long eyes with the Lepper and Trier formula, the Holladay formula, and the SRK/T method. The highest accuracy was found with the Binkhorst formula and our previously described linear regression formula which expresses the pseudophakic ACD as a function of the average pseudophakic ACD for a given lens style, the preoperative ACD, and the axial length. The use of the preoperative ACD in combination with the axial length for the prediction of the pseudophakic ACD can therefore be expected to improve the accuracy of IOL power calculation.
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PMID:Prediction of pseudophakic anterior chamber depth with the newer IOL calculation formulas. 159 34

Allergic reactions caused by colloid plasma substitutes are a well known complication in infusion therapy. The incidence of these adverse effects depends on the type of colloid used. Severe anaphylactic or anaphylactoid reactions are generally rare. Nevertheless, the risk of adverse allergic effects is an important aspect of the crystalloid-versus-colloid controversy. The exact pathophysiologic mechanisms remain as yet unclear; reliable prophylactic measures are not universally available. To draw attention to these problems we report a case of severe anaphylactoid reaction to Physiogel SRK.
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PMID:[Anaphylactoid reaction to Physiogel SRK 4%--a contribution to the controversy about plasma substitutes]. 141 14

The authors deal with the postoperative dioptric deviation from the calculated optic potency of the emetropic intraocular lens, using formulae SRK II, SRK/T and Holladay's formula. Within the range +/- 1.5 D the deviation varied in 84% of the operated eyes where the intraocular lens was assessed according to formula SRK II; in 76% when formula SRK/T was used and in 74% when Holladay's formula was used. The authors give also an account of possible sources of errors during measurement, calculation and evaluation of results.
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PMID:[Calculations for intraocular lenses]. 173 95

A retrospective study of 183 eyes that had undergone extracapsular cataract extraction and posterior chamber intraocular lens (IOL) implantation was undertaken to compare the accuracy of eight IOL power calculation formulas (modified Binkhorst, Colenbrander, Gullstrand, Fyodorov-Galin-Linksz, Gill, Axt, Donzis-Kastle-Gordon and SRK regression). We found that the regression formulas were more accurate than the theoretical formulas, giving enough approximation to the ideal IOL as to assure its clinical use. We prefer the SRK formula because it is easier and it has a constant A that can be adapted in a personalized way to each surgical team.
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PMID:A comparative study of eight intraocular lens calculation formulas. 177 3

Axial length and corneal curvature are entered into formulae to calculate intraocular lens power for cataract surgery and the absolute measurement of fundus structures such as neuroretinal rim area in glaucoma. The reproducibility (coefficient of variation, CV) of biometry and keratometry was investigated by taking five measurements of thirty phakic eyes. Although both techniques were found to be highly reproducible (CV less than 1%), keratometry was the more so. However, a clinically significant difference was noted between the first and the mean of five readings for both biometry (0.15 +/- 0.05 mm) and keratometry (0.05 +/- 0.03). Taken together, these errors would result in a postoperative refractive error of 0.65D using the SRK formula. Measurement errors were just as likely to occur with short or long eyes. Similar results were found when the analysis was performed on three measurements of both axial length and corneal curvatures. We recommend taking the average of three biometry and keratometry readings to improve the reliability of the techniques, and to increase the accuracy of calculating intraocular lens power and fundus structure dimensions.
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PMID:The reproducibility of biometry and keratometry measurements. 180 Jan 71

It was previously reported that the axial length and the refractive error were analyzed in selecting intraocular lens powers which were calculated by the SRK formula. Moreover, the predicted postoperative refraction was compared with the actual postoperative refraction. Two modifications of the SRK formula were derived from these relationships as follows; Modified SRK formula 1: R = 0.98 (P-I)-0.16L + 4.48, Modified SRK formula 2: R = 0.82 (P-I)-0.21L + 5.39. The modifications of the SRK formula were evaluated in 200 other eyes after posterior chamber lens implantation. As a result, the average refractive error was + 0.397 +/- 0.585D by the standard SRK formula, but it decreased by an average numbers of + 0.037 +/- 0.557D and + 0.047 +/- 0.547D respectively by modified SRK formulae 1 and 2. While the incidence of deviation within +/- 1.0D was 87.0% for the standard SRK formula, it was 94. 5% for both modified SRK formulas. The refractive errors, moreover, were less dependent on the axial length with both modified SRK formulae. The predicted postoperative refraction was more accurate by modified SRK formulae, especially between emmetropia and myopia up to 0.5 diopters.
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PMID:[Clinical evaluation of modifications of the SRK formula]. 187 12

The authors investigate the postoperative dioptric deviation from the calculated dioptric power of emetropic intraocular lenses by means of the SRK formula. The deviation varied in 82% of the operated eyes within the range of +/- 1.5 D. More accurate calculations were achieved in a group of eyes with a normal axial length of the eyeball (22.0 to 24.5 mm). The authors discuss also circumstances which influence the accuracy of calculation according to formula SRK (assessment, calculation) and factors participating in the final postoperative refraction (different surgical techniques).
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PMID:[Reliability of the SRK formula]. 191

The aim of this study was to determine the range of ametropias encountered by using the computerized Ophthasonic A-Scan. The SRK formula was used to compute the IOL power using axial length and keratometry as inputs. The accuracy of prediction of IOL power was calculated by noting the disparity between the expected post-operative refraction and the actual refraction obtained after one and a half months of IOL implantation. The results obtained were encouraging; the maximum deviation from the expected result being +/- 3.2 D.
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PMID:Prediction of intra ocular lens power in 100 patients using the ophthasonic a scan unit. 191 79

Premofil M SRK, licensed in Switzerland by the IKS since mid-1990, was clinically tested in close collaboration with 7 hemophilia treatment centers. Up to May 1991, we collected results of in vivo recovery from 17 patients, half-life determinations from 12, and safety data from 9 who were exclusively treated with the preparation for several months. The mean in vivo recovery of factor VIII was calculated to be 77 +/- 14%; the rise in factor VIII activity in plasma following injection of one unit/kg body weight was 1.6 +/- 0.3 units/dl. The mean halflife was 11.9 +/- 4.6 hours. No side reactions were registered throughout the study period. None of the patients showed any signs of HIV or hepatitis infection. It can bei concluded that Premofil M SRK fulfills the requirements related to tolerance, efficacy and safety for a factor VIII concentrate.
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PMID:[Clinical testing of Premofil M SRK, a blood coagulation factor VIII concentrate purified from human plasma using monoclonal an antibodies]. 194 60

The accuracy of two newer generation theoretical intraocular lens (IOL) power calculation formulas and of the empirical SRK I and II formulas was evaluated in a series of 500 IOL implantations including a series of unusually long and short eyes. The prediction error of the theoretical formulas was found to be largely unaffected by the variation in axial length and corneal power, while the prediction of the SRK I formula was less accurate in the short and long eyes. The prediction of the SRK II formula was more accurate than the SRK I in that no systematic offset error with axial length could be demonstrated. However, because of a relatively larger scatter in the long eyes and a significant bias with the corneal power, the absolute error of the SRK II formula was higher than that of the theoretical formulas in the long eyes. The higher accuracy of the newer generation theoretical formulas was attributed to their improved prediction of the pseudophakic anterior chamber depth.
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PMID:Accuracy of the newer generation intraocular lens power calculation formulas in long and short eyes. 204 Sep 76


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