Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: EC:2.7.10.1 (ERK)
95,504 document(s) hit in 31,850,051 MEDLINE articles (0.08 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein ERK 26251 EGFR 13873 HER2 11271 Mol 7521 MAPK 7296 tyrosine kinase 7100 Sep 5880 MEK 5878 p38 5454 PCL 5068 AKT 4790 ERK1 4665 JNK 4570 epidermal growth factor receptor 4537 PI3K 4331 MET 4235 KIT 4073 p53 3808 RET 3280 VEGFR2 3078 receptor tyrosine kinase 2991 BRAF 2757 ALK 2644 vascular endothelial growth factor 2495 FLT3 2438 mTOR 2431 cytokine 2373 VEGF 2119 KRAS 2058 anaplastic lymphoma kinase 1986 FGFR1 1884 estrogen receptor 1813 KDR 1700 EGF 1689 ERBB2 1676 neu 1665 epidermal growth factor 1606 caspase-3 1605 collagen 1603 insulin 1599 TNF 1519 PDGFR 1491 MAP kinase 1400 Bcl-2 1386 IL-6 1350 extracellular signal-regulated kinase 1350 MEK1 1313 mitogen-activated protein 1283 NET 1274 STAT3 1258 PTEN 1255 FGFR2 1247 PDGFRA 1197 FGFR3 1122 ATP 1109 EGF receptor 1039 VEGFR-1 1034 PIK3CA 1031 IGF1R 1020 CD34 1019 c-fms 1000 PKC 987 c-Jun 955 progesterone receptor 951 RAF 938 ERK2 930 cyclin D1 927 p21 914 phosphatidylinositol 3-kinase 871 catenin 865 E-cadherin 851 phosphatase 834 c-kit 832 hepatocyte growth factor 832 AP-1 826 PEG 824 erbB-2 814 Ki-67 807 tumor necrosis factor 805 lipopolysaccharide 802 more...

Disease cancer 25120 tumor 21111 breast cancer 10031 PCL 5083 lung cancer 3798 carcinoma 3663 tumor growth 3226 non-small cell lung cancer 3099 tumorigenesis 2910 metastases 2746 adenocarcinoma 2738 acute myeloid leukemia 2629 tumor progression 2047 leukemia 1874 melanoma 1852 colorectal cancer 1805 carcinogenesis 1584 hepatocellular carcinoma 1495 gastric cancer 1196 MCF 1193 squamous cell carcinoma 1173 glioblastoma 1120 lymphoma 1055 glioma 1048 metastatic breast cancer 1030 prostate cancer 964 lung carcinoma 913 stromal tumors 898 ovarian cancer 855 diabetes 834 gastrointestinal stromal tumor 813 Alzheimer's disease 757 colon cancer 753 medullary thyroid carcinoma 752 neuroblastoma 736 HEP 714 primary tumor 709 ischemia 702 multiple endocrine neoplasia 683 pancreatic cancer 673 anaplastic large cell lymphoma 669 hypertension 618 sarcoma 608 obesity 564 renal cell carcinoma 563 achondroplasia 546 chronic myeloid leukemia 526 aggressiveness 512 multiple myeloma 495 tumor angiogenesis 486 atherosclerosis 484 thyroid cancer 477 HGF 476 Leukemia 464 depression 456 HIV 448 psychopathy 440 bladder cancer 434 pheochromocytoma 428 papillary thyroid cancer 419 brain metastases 399 ABL 378 glioblastoma multiforme 369 ductal carcinoma 367 mastocytosis 364 liver cancer 349 ATM 345 brain tumor 340 stroke 333 acute lymphoblastic leukemia 327 cold 324 Hodgkin's disease 321 dysplasia 316 osteosarcoma 312 myelodysplastic syndrome 311 Blocking 309 asthma 305 heart failure 303 Hippel 303 MEN 2 303 more...

Symptom pain 701 diarrhea 388 fatigue 267 nausea 195 starvation 180 seizures 153 vomiting 137 headache 108 functional recovery 102 abdominal pain 99 anesthesia 87 weakness 77 collapse 75 cough 75 splenomegaly 73 dyspnea 72 overweight 68 anorexia 54 analgesia 53 exhaustion 48 respiratory distress 46 constipation 45 hypothermia 44 discomfort 43 discomfort 40 hyperoxia 38 anosmia 37 erythema 37 flushing 34 thinning 30 acidity 29 ataxia 28 back pain 28 dizziness 27 HSA 26 decreased appetite 25 memory loss 24 tremor 24 asthenia 24 bone pain 24 nausea and vomiting 24 chest pain 23 hepatosplenomegaly 22 arthralgia 22 chills 22 distraction 22 cachexia 22 skin damage 21 Ill 21 shortness of breath 21 low back pain 21 insomnia 20 hepatomegaly 19 angina 19 dry skin 18 epigastric pain 18 hemoptysis 17 syncope 17 myalgia 17 acute stress 14 nipple discharge 14 agitation 14 hypercapnia 14 nipple discharge 14 Scratch 14 Neuropathic pain 14 skin irritation 11 Welt 11 fasciculation 11 acute pain 11 exertional dyspnea 10 orofacial pain 10 dysuria 10 pelvic pain 10 night sweats 9 lethargy 9 pallor 9 hunger 8 abdominal discomfort 8 muscle cramps 8 more...

Drug ENT 1283 Herceptin 1075 MAP 878 ROS 738 Imatinib 483 Dermatol 449 CSF 359 Gefitinib 358 lysine 349 IL-2 293 Gleevec 267 PTC 257 Cetuximab 241 Sorafenib 233 IFN-gamma 215 Erlotinib 213 DM1 184 ETS 171 Monit 138 Bevacizumab 138 Cardiovasc 130 ICI 122 NVP 114 uPA 97 Gel 95 GEO 91 MTC 85 G-CSF 83 Taxol 82 Angiotensin II 82 Dasatinib 82 ROC 76 EE2 75 ascorbate 75 ABC 71 TEL 71 CAM 71 p75 68 Docetaxel 68 Pertuzumab 68 KGF 64 vitamin E 62 Leaf 61 Paraffin 60 MRC 57 Tarceva 56 Mutagen 56 PTH 55 CTX 51 caffeine 50 MDS 49 Vandetanib 48 CTC 45 Midostaurin 45 Asn 44 Activin 43 NADH 43 Heme 41 Panitumumab 39 Adriamycin 39 Everolimus 39 Asthma 37 TAT 37 Ethanol 37 TAK 37 Retinoic acid 36 CPT-11 36 ADM 35 Fulvestrant 35 Simvastatin 33 ALA 33 Gelatin 32 ADR 32 Arsenic trioxide 32 Nephron 31 Ouabain 30 anti-CD33 29 ETA 29 CCL 29 Fluorescein 28 more...

Enzyme ERK 95504 mitogen-activated protein kinase 16661 MEK 6869 focal adhesion kinase 3081 protein kinase 3041 protein kinase C 1847 caspase-3 1219 luciferase 980 phosphatidylinositol 3-kinase 871 MAP 799 CD10 738 PARP 697 ACS 476 proteasome 437 alkaline phosphatase 418 AMP-activated protein kinase 407 phosphoinositide 3-kinase 396 superoxide dismutase 364 phospholipase C 353 AMPK 353 cdc2 338 calcineurin 333 catalase 328 reverse transcriptase 306 GSK 304 AMPK 304 peroxidase 289 NADPH oxidase 288 RNA polymerase 277 ATPase 276 caspase-9 275 APC 273 NADPH oxidase 258 urokinase-type plasminogen activator 246 IKK 245 collagenase 241 MEKK1 224 caspase-8 223 glutathione S-transferase 208 thrombin 201 lactate dehydrogenase 189 trypsin 186 DAT 181 MMP 174 alanine aminotransferase 174 P-glycoprotein 160 CaMKII 149 NO synthase 147 PDK1 145 NOS 143 succinate dehydrogenase 141 topoisomerase 135 ACE 134 aspartate aminotransferase 131 topoisomerase 130 STK 127 succinyl-CoA synthetase 124 renin 117 phospholipase A2 115 adenylate cyclase 111 lipase 107 CD13 104 tyrosinase 104 thymidine kinase 103 tryptase 100 RNase 100 STK11 99 glutathione peroxidase 96 protein phosphatase 2A 94 RNase 94 tyrosine hydroxylase 93 transcriptase 92 MIP 90 lysozyme 88 neuraminidase 88 phosphodiesterase 85 acetylcholinesterase 81 plasmin 78 DNA methyltransferase 78 NQO1 77 more...

Compound DNA 7325 Dec 6419 MEK 5768 tyrosine 5536 methionine 4612 Clin 3636 oxygen 2420 calcium 1887 water 1583 TNF 1519 glucose 1327 PEG 1217 MDA 1202 MTT 1153 ATP 1112 serine 1104 PEG 1092 phosphate 947 cAMP 933 threonine 890 acetate 851 MAP 834 sodium 805 nitric oxide 780 HEP 714 cysteine 699 hydrogen 635 arginine 553 lysine 496 ACS 478 ACS 475 sulfate 457 retinoic acid 398 BCR 389 glutamate 389 alanine 386 ABL 385 leucine 375 Insulin 374 Phe 370 iron 359 ethanol 329 GTP 315 zinc 313 GSH 294 GSH 294 salt 286 iodine 282 urea 281 AMP 280 PMA 276 nitrogen 273 Asp 270 NH2 268 His 265 THP 264 THP 264 PLA 262 PMA 247 N-acetylcysteine 247 H2O2 245 potassium 242 Tyrosine 233 bromide 230 TNM 228 TIF 228 galactose 224 Luminal 211 pyrimidine 209 PGE 208 Cardiol 205 pyrimidine 203 Estrogen 195 Estrogen 195 COS 191 proline 183 TEM 182 DAT 181 Gly 179 5-HT 176 more...

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