Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.1 (ERK)
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Human Gene/Protein
C14orf181 8.4
GCST 8.4
guanine nucleotide-releasing factor 2 8.4
ZMYM6 8.4
Ubiquitin-conjugating enzyme E2 J2 8.4
AP1G2 8.4
HNK1ST 8.4
CAPPA1 8.4
PLSCR5 8.4
ZNF526 8.4
CSF1R 8.4
MS4A6 8.4
OR8S1 8.4
TYRO3 protein 8.4
ELK1, member of ETS oncogene family 8.4
transforming growth factor, alpha 8.4
protein tyrosine phosphatase, receptor type, f polypeptide 8.4
MET 8.4
C8orf55 8.4
F-box and leucine-rich repeat protein 6 8.4
RET 8.4
chromosome 7 open reading frame 41 8.4
CRISPLD1 8.4
HIST1H2AI 8.4
UEVLD 8.4
spectrin repeat containing, nuclear envelope 2 8.4
EHK1 8.4
OR4C16 8.4
TYRO4 8.4
TMEM167A 8.4
MRIP-1 8.4
C9orf43 8.4
PDGFRB 8.4
RYK protein 8.4
MER receptor tyrosine kinase 8.4
anaplastic lymphoma kinase 8.4
FAM160B2 8.4
TMEM108 8.4
HER3 8.4
SRF accessory protein 1 8.4
more...
Disease
FIM1 8.4
Idiopathic eosinophilia 8.4
Haemangioblastomatosis 8.4
Spindle Cell Tumor 8.4
ALKoma 8.4
metastatic adult soft tissue sarcoma 8.4
Bent bone dysplasia 8.4
T-cell lymphoma refractory 8.4
childhood large cell lymphoma 8.4
MLVI2 8.4
Inflammatory fibroid polyps of stomach 8.4
AML with recurrent genetic abnormality 8.4
Bowen's disease, pagetoid 8.4
genetics of medullary thyroid cancer 8.4
Mesenchymal Neoplasm 8.4
Reactive mastocytosis 8.4
HEP 8.4
PCL 8.4
JWS 8.0
VMCM 7.9
KAL2 7.9
SM-AHNMD 7.6
Pilocytic Astrocytoma 7.4
Say-Meyer syndrome 7.4
Glycogen-rich carcinoma 7.4
low-grade salivary gland carcinoma 7.4
Cystic hypersecretory carcinoma 7.4
adult brainstem glioma 7.4
High altitude polycythemia 7.4
adenosquamous cell lung cancer 7.4
MEN 2B 7.3
Medullary Thyroid Carcinoma 7.2
chronic eosinophilic leukemia 7.2
MEN 2 7.1
mast cell leukemia 7.1
Secretory Carcinoma 7.1
achondroplasia 7.0
anaplastic large cell lymphoma 7.0
HSAN IV 6.9
Pulmonary granulomatosis 6.8
more...
Symptom
Oral pruritus 8.4
Increased skin sensitivity 8.4
retracted nipple 6.8
Braxton Hicks contractions 5.6
High weight 4.1
Respiratory abnormalities 4.0
unable to sleep 3.9
difficulty with urination 3.6
Erythema annulare centrifugum 3.6
Sore 3.6
Scratch 3.6
peau d'orange 3.5
Intermenstrual bleeding 3.4
ACHE 3.3
hyperosmia 3.3
breast hyperplasia 3.3
nipple discharge 3.2
Inflammatory pain 3.2
nipple discharge 3.1
anosmia 3.0
Spotting 2.9
peri-menopausal 2.9
decreased appetite 2.8
stomach cramps 2.8
irregular bleeding 2.8
Beau's lines 2.7
BHS 2.6
Severe diarrhea 2.6
dry skin 2.6
female puberty 2.5
GI irritation 2.4
periorbital edema 2.4
eye discharge 2.3
Skin symptoms 2.3
skin damage 2.2
No toxic effect 2.0
Lhermitte's sign 2.0
prominent nose 2.0
Motor dysfunction 2.0
delayed language development 2.0
more...
Drug
ERLOTINIB 8.4
Diapid 8.4
Cetyl-Trimethyl-Ammonium 8.4
Pelitinib 8.4
Mubritinib 8.1
Midostaurin 7.9
Pertuzumab 7.4
Condurango 7.4
Herceptin 7.3
Lestaurtinib 7.3
Tykerb 7.2
Tandutinib 7.2
Vandetanib 6.9
Nicergolin 6.8
Tiqueside 6.8
Timefurone 6.8
Poliglecaprone 25 6.8
Gefitinib 6.6
Erlotinib 6.6
Tarceva 6.4
Cetuximab 6.4
Efipladib 6.4
D-Aspartic Acid 6.4
Antirabies serum 6.4
Panitumumab 6.3
Motesanib 6.3
Nexavar 6.2
Rimexolone 6.1
Mudanpi 6.1
Ecadotril 6.1
Imatinib 6.0
Sunitinib malate 6.0
Gleevec 6.0
Dexamethasone acetate 5.9
MTC 5.8
Fudosteine 5.8
Xaliproden 5.8
Vatalanib 5.7
Sorafenib 5.7
Axitinib 5.7
more...
Enzyme
ERK 8.4
STK 8.2
L-rhamnonate dehydratase 7.4
L-rhamnonate dehydratase 7.4
MEK 7.0
zingipain 6.8
L-rhamnose 1-dehydrogenase 6.8
succinyl-CoA synthetase 6.7
dipeptidyl-dipeptidase 6.4
D-2-hydroxy acid dehydrogenase 6.4
STK11 6.1
mitogen-activated protein kinase 5.9
sorbose dehydrogenase 5.7
complement subcomponent C1r 5.6
prenylated protein methyltransferase 5.4
DAT 5.4
MEKK1 5.3
STK13 5.2
MAP 5.2
HK3 5.2
DNA 3'-phosphatase 5.2
acylcarnitine hydrolase 5.0
CobS 4.9
phosphatidylinositol-4,5-bisphosphate 3-kinase 4.9
hepsin 4.9
hepsin 4.9
inositol 3-kinase 4.9
gamma-butyrobetaine hydroxylase 4.8
matrix metalloproteinase 10 4.8
matriptase 4.8
matriptase 4.8
phosphatidylinositol 3-kinase 4.7
CD10 4.7
CEP 4.6
focal adhesion kinase 4.5
STK4 4.5
GK2 4.5
phosphoinositide 3-kinase 4.5
meprin B 4.5
STK2 4.4
more...
Compound
C15H20O 8.4
C15H20O 8.4
Iodinin 8.4
1-Propylagroclavine tartrate 8.4
C15H20O 8.4
C25H30N2O5 8.4
C15H20O 8.4
HEP 8.4
C15H20O 8.4
C15H20O 8.4
Strebloside 8.4
2-(trifluoromethyl)-10H-phenothiazine 8.4
C15H20O 8.4
4-(3-chloropropyl)morpholine 8.4
Isobutyl methacrylate 8.4
1,3,7-Trihydroxyxanthone 8.4
C15H20O 8.4
TIF 8.4
Ethyl Malonate 8.4
C15H20O 8.4
C15H20O 8.4
C15H20O 8.4
Spiclomazine 8.4
2-Keto-L-gulonic acid 7.9
2,4,5-trichloropyrimidine 7.8
4-fluoro-2-methylphenol 7.4
C7H14N2O3 7.4
C15H20O 7.4
14H-dibenzo[a,j]xanthene 7.4
C7H14N2O3 7.4
C11H14O6 7.4
C7H14N2O3 7.4
Neoastilbin 7.4
C13H18N2 7.4
C7H14N2O3 7.4
C15H20O 7.4
C7H14N2O3 7.4
1,2,3,4,5,6-hexabromocyclohexane 7.4
C7H14N2O3 7.4
C7H14N2O3 7.4
more...