Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.1 (ERK)
 95,504 document(s) hit in 31,850,051 MEDLINE articles (0.08 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
ERK 26251
EGFR 13873
HER2 11271
Mol 7521
MAPK 7296
tyrosine kinase 7100
Sep 5880
MEK 5878
p38 5454
PCL 5068
AKT 4790
ERK1 4665
JNK 4570
epidermal growth factor receptor 4537
PI3K 4331
MET 4235
KIT 4073
p53 3808
RET 3280
VEGFR2 3078
receptor tyrosine kinase 2991
BRAF 2757
ALK 2644
vascular endothelial growth factor 2495
FLT3 2438
mTOR 2431
cytokine 2373
VEGF 2119
KRAS 2058
anaplastic lymphoma kinase 1986
FGFR1 1884
estrogen receptor 1813
KDR 1700
EGF 1689
ERBB2 1676
neu 1665
epidermal growth factor 1606
caspase-3 1605
collagen 1603
insulin 1599
TNF 1519
PDGFR 1491
MAP kinase 1400
Bcl-2 1386
IL-6 1350
extracellular signal-regulated kinase 1350
MEK1 1313
mitogen-activated protein 1283
NET 1274
STAT3 1258
PTEN 1255
FGFR2 1247
PDGFRA 1197
FGFR3 1122
ATP 1109
EGF receptor 1039
VEGFR-1 1034
PIK3CA 1031
IGF1R 1020
CD34 1019
c-fms 1000
PKC 987
c-Jun 955
progesterone receptor 951
RAF 938
ERK2 930
cyclin D1 927
p21 914
phosphatidylinositol 3-kinase 871
catenin 865
E-cadherin 851
phosphatase 834
c-kit 832
hepatocyte growth factor 832
AP-1 826
PEG 824
erbB-2 814
Ki-67 807
tumor necrosis factor 805
lipopolysaccharide 802
MAP 797
vascular endothelial growth factor receptor 788
HER3 763
NRAS 761
proto-oncogene 751
ROS 743
CREB 738
PDGF 723
HEP 714
FGF 711
Raf-1 709
IL-8 697
tyrosine kinase receptor 696
platelet-derived growth factor 687
hormone receptor 686
ROS1 664
p65 658
LPS 654
PARP 639
platelet-derived growth factor receptor 617
NEP 608
MYC 605
lymphoid 604
fibronectin 603
vimentin 592
STAT 586
MMP-9 585
AXL 582
osteogenic 582
IFN 578
CD4 573
fused 569
NMR 567
threonine 566
FISH 556
histone 550
IRR 549
FAK 542
inducible nitric oxide synthase 540
NPM1 539
matrix metalloproteinase 538
COX-2 537
insulin-like growth factor 525
CD44 513
CDK4 504
CD117 503
brain-derived neurotrophic factor 502
chemokine 496
CD8 496
Vascular endothelial growth factor 495
c-fos 493
c-Met 488
extracellular signal-regulated kinase 1 483
JAK2 481
PKA 479
CD31 477
ACS 475
FGF receptor 475
HGF 475
mast cell 474
BRCA1 474
Rho 461
endoplasmic reticulum 452
p27 451
PD-L1 447
IL-10 443
TLR4 442
ACH 439
AML 437
tyrosine kinase 3 435
cage 427
EML4 427
RET proto-oncogene 427
neuregulin 424
proteasome 423
MMP-2 422
Met 422
protein kinase B 421
nodal 420
alkaline phosphatase 418
more...
Disease
cancer 25120
tumor 21111
breast cancer 10031
PCL 5083
lung cancer 3798
carcinoma 3663
tumor growth 3226
non-small cell lung cancer 3099
tumorigenesis 2910
metastases 2746
adenocarcinoma 2738
acute myeloid leukemia 2629
tumor progression 2047
leukemia 1874
melanoma 1852
colorectal cancer 1805
carcinogenesis 1584
hepatocellular carcinoma 1495
gastric cancer 1196
MCF 1193
squamous cell carcinoma 1173
glioblastoma 1120
lymphoma 1055
glioma 1048
metastatic breast cancer 1030
prostate cancer 964
lung carcinoma 913
stromal tumors 898
ovarian cancer 855
diabetes 834
gastrointestinal stromal tumor 813
Alzheimer's disease 757
colon cancer 753
medullary thyroid carcinoma 752
neuroblastoma 736
HEP 714
primary tumor 709
ischemia 702
multiple endocrine neoplasia 683
pancreatic cancer 673
anaplastic large cell lymphoma 669
hypertension 618
sarcoma 608
obesity 564
renal cell carcinoma 563
achondroplasia 546
chronic myeloid leukemia 526
aggressiveness 512
multiple myeloma 495
tumor angiogenesis 486
atherosclerosis 484
thyroid cancer 477
HGF 476
Leukemia 464
depression 456
HIV 448
psychopathy 440
bladder cancer 434
pheochromocytoma 428
papillary thyroid cancer 419
brain metastases 399
ABL 378
glioblastoma multiforme 369
ductal carcinoma 367
mastocytosis 364
liver cancer 349
ATM 345
brain tumor 340
stroke 333
acute lymphoblastic leukemia 327
cold 324
Hodgkin's disease 321
dysplasia 316
osteosarcoma 312
myelodysplastic syndrome 311
Blocking 309
asthma 305
MEN 2 303
heart failure 303
Hippel 303
rheumatoid arthritis 302
SEM 295
Parkinson's disease 292
GSH 284
B-cell lymphoma 283
epithelial ovarian cancer 281
WT1 280
pertussis 278
mammary tumor 276
small cell lung cancer 276
anemia 274
APC 269
type 2 diabetes 268
Melanoma 265
aggression 263
SCID 262
posttraumatic stress disorder 260
myeloproliferative disorders 254
ductal carcinoma in situ 250
solid tumor 249
leukemogenesis 247
EMT 245
osteoporosis 244
cervical cancer 244
craniosynostosis 240
liver metastases 233
liver cancer 229
Glioblastoma 227
myocardial infarction 226
acute promyelocytic leukemia 218
neutropenia 217
MEN 2B 217
addiction 214
eosinophilia 209
schizophrenia 207
Epstein 206
Luminal 206
arthritis 206
endometrial cancer 205
retinoblastoma 203
thalassemia 203
metastatic melanoma 202
sepsis 201
cardiovascular disease 197
infectious diseases 195
rash 194
residual disease 193
T-cell lymphoma 193
sepsis 193
fibrosarcoma 190
Hepatocellular carcinoma 187
DM1 187
adenoma 187
hyperglycemia 187
uterus 186
immunodeficiency 185
skin cancer 184
virus infection 184
chronic lymphocytic leukemia 181
influenza 177
osteoarthritis 176
herpes simplex 169
cognitive impairment 169
astrocytoma 164
lung metastases 164
acute leukemia 163
hematologic malignancies 161
bone metastases 160
head and neck cancer 158
mole 157
minimal residual disease 156
tumor initiation 154
plaque 153
preeclampsia 153
chronic lymphocytic leukemia 152
SDS 149
chronic obstructive pulmonary disease 148
NOD 148
Neuroblastoma 147
colitis 147
more...
Symptom
pain 701
diarrhea 388
fatigue 267
nausea 195
starvation 180
seizures 153
vomiting 137
headache 108
functional recovery 102
abdominal pain 99
anesthesia 87
weakness 77
collapse 75
cough 75
splenomegaly 73
dyspnea 72
overweight 68
anorexia 54
analgesia 53
exhaustion 48
respiratory distress 46
constipation 45
hypothermia 44
discomfort 43
discomfort 40
hyperoxia 38
erythema 37
anosmia 37
flushing 34
thinning 30
acidity 29
back pain 28
ataxia 28
dizziness 27
HSA 26
decreased appetite 25
asthenia 24
memory loss 24
tremor 24
nausea and vomiting 24
bone pain 24
chest pain 23
hepatosplenomegaly 22
distraction 22
arthralgia 22
cachexia 22
chills 22
Ill 21
shortness of breath 21
low back pain 21
skin damage 21
insomnia 20
angina 19
hepatomegaly 19
dry skin 18
epigastric pain 18
hemoptysis 17
myalgia 17
syncope 17
Neuropathic pain 14
hypercapnia 14
Scratch 14
nipple discharge 14
nipple discharge 14
acute stress 14
agitation 14
Welt 11
fasciculation 11
skin irritation 11
acute pain 11
exertional dyspnea 10
orofacial pain 10
dysuria 10
pelvic pain 10
lethargy 9
night sweats 9
pallor 9
abdominal discomfort 8
hunger 8
muscle cramps 8
wheezing 8
irregular bleeding 8
cancer pain 8
sore throat 7
ENT 7
acute abdominal pain 7
hopelessness 7
hoarseness 7
ACHE 7
hypotonia 7
acute abdomen 7
DNA marker 7
chronic constipation 7
paresis 7
colic 6
stigma 6
dysarthria 6
despair 6
dry eye 6
spasticity 6
regurgitation 6
polyuria 6
paraparesis 6
menopausal symptoms 5
neck pain 5
hip pain 5
tinnitus 5
vertigo 5
sleepiness 5
dystonia 5
Depressive symptoms 5
bloating 5
bradykinesia 5
fever of unknown origin 5
numbness 5
paresthesia 5
spasm 4
periorbital edema 4
eds 4
Fluctuation 4
apathy 4
alexithymia 4
peri-menopausal 4
cerebellar ataxia 4
myoclonus 4
rhinorrhea 4
knee pain 4
heartburn 3
hemiplegia 3
sneezing 3
blurred vision 3
stridor 3
general problem 3
POA 3
CSR 3
neurological disability 3
masculinization 3
Stiffness 3
abnormal gait 3
leg pain 3
Gastrointestinal symptoms 3
Burning 3
hypertonia 3
microbial colonization 3
peau d'orange 3
flank pain 3
neuralgia 3
body pain 3
productive cough 3
lightheadedness 3
cyanosis 3
chest tightness 2
abdominal fullness 2
clubbing 2
hot flashes 2
throat irritation 2
Decreased activity 2
Inflammatory pain 2
nasal discharge 2
hyperemesis gravidarum 2
more...
Drug
ENT 1283
Herceptin 1075
MAP 878
ROS 738
Imatinib 483
Dermatol 449
CSF 359
Gefitinib 358
lysine 349
IL-2 293
Gleevec 267
PTC 257
Cetuximab 241
Sorafenib 233
IFN-gamma 215
Erlotinib 213
DM1 184
ETS 171
Bevacizumab 138
Monit 138
Cardiovasc 130
ICI 122
NVP 114
uPA 97
Gel 95
GEO 91
MTC 85
G-CSF 83
Angiotensin II 82
Dasatinib 82
Taxol 82
ROC 76
EE2 75
ascorbate 75
ABC 71
TEL 71
CAM 71
Pertuzumab 68
Docetaxel 68
p75 68
KGF 64
vitamin E 62
Leaf 61
Paraffin 60
MRC 57
Tarceva 56
Mutagen 56
PTH 55
CTX 51
caffeine 50
MDS 49
Vandetanib 48
CTC 45
Midostaurin 45
Asn 44
Activin 43
NADH 43
Heme 41
Adriamycin 39
Panitumumab 39
Everolimus 39
TAK 37
Ethanol 37
TAT 37
Asthma 37
CPT-11 36
Retinoic acid 36
ADM 35
Fulvestrant 35
ALA 33
Simvastatin 33
ADR 32
Arsenic trioxide 32
Gelatin 32
Nephron 31
Ouabain 30
anti-CD33 29
CCL 29
ETA 29
Indomethacin 28
Fluorescein 28
Estrogens 28
Bortezomib 28
RFP 28
PCP 27
G418 27
Sunitinib malate 27
Histamine 26
CDX 26
nitroglycerin 26
CTX 26
CDX 26
Pemetrexed 26
Albumin 26
Rituximab 25
CTX 25
IL-11 25
Tykerb 25
TTC 24
lactose 24
Norplant 24
Nexavar 23
Alliance 23
citric acid 23
TAC 23
Forskolin 23
IFN-beta 22
Nitric Oxide 22
DNase I 22
Vitamin E 21
CTC 21
NH3 21
Growth hormone 21
THF 21
Growth hormone 20
Axitinib 20
ampicillin 20
PDL 20
Glucagon 20
Taxotere 20
Lovastatin 19
Epigallocatechin 19
Alanine 19
Oxaliplatin 18
Emodin 17
EPA 17
Emodin 17
DHT 17
TiO2 17
DHT 17
Itraconazole 16
Portal 16
Fluorescein 16
ZnO 16
Spectrum 15
Dial 15
FAD 14
Vinorelbine 14
CoCl2 14
Glutathione 14
CoCl2 14
Irinotecan 14
Fragment 14
Biopolymers 13
HCG 13
Gastro 13
SiO2 13
Check 13
Vorinostat 13
Etoposide 12
Isotretinoin 12
Retinoic Acid 12
IL-1ra 12
Silica 12
PDGF B-chain 12
HCH 12
DEX 12
Cremophor EL 12
Triclosan 11
Troglitazone 11
more...
Enzyme
ERK 95504
mitogen-activated protein kinase 16661
MEK 6869
focal adhesion kinase 3081
protein kinase 3041
protein kinase C 1847
caspase-3 1219
luciferase 980
phosphatidylinositol 3-kinase 871
MAP 799
CD10 738
PARP 697
ACS 476
proteasome 437
alkaline phosphatase 418
AMP-activated protein kinase 407
phosphoinositide 3-kinase 396
superoxide dismutase 364
AMPK 353
phospholipase C 353
cdc2 338
calcineurin 333
catalase 328
reverse transcriptase 306
AMPK 304
GSK 304
peroxidase 289
NADPH oxidase 288
RNA polymerase 277
ATPase 276
caspase-9 275
APC 273
NADPH oxidase 258
urokinase-type plasminogen activator 246
IKK 245
collagenase 241
MEKK1 224
caspase-8 223
glutathione S-transferase 208
thrombin 201
lactate dehydrogenase 189
trypsin 186
DAT 181
MMP 174
alanine aminotransferase 174
P-glycoprotein 160
CaMKII 149
NO synthase 147
PDK1 145
NOS 143
succinate dehydrogenase 141
topoisomerase 135
ACE 134
aspartate aminotransferase 131
topoisomerase 130
STK 127
succinyl-CoA synthetase 124
renin 117
phospholipase A2 115
adenylate cyclase 111
lipase 107
tyrosinase 104
CD13 104
thymidine kinase 103
RNase 100
tryptase 100
STK11 99
glutathione peroxidase 96
RNase 94
protein phosphatase 2A 94
tyrosine hydroxylase 93
transcriptase 92
MIP 90
lysozyme 88
neuraminidase 88
phosphodiesterase 85
acetylcholinesterase 81
DNA methyltransferase 78
plasmin 78
NQO1 77
DCF 76
granzyme B 73
MMP-3 72
cathepsin K 67
AST 66
phospholipase D 62
MDR 61
glyceraldehyde-3-phosphate dehydrogenase 61
PKG 60
GRK5 59
CEP 57
matrix metalloproteinase 2 54
CEP 54
guanylate cyclase 54
CYP3A4 53
matrix metalloproteinase 9 52
farnesyltransferase 50
heme oxygenase 48
beta-galactosidase 48
GRK2 48
farnesyltransferase 48
creatine kinase 47
demethylase 47
isocitrate dehydrogenase 47
caspase-1 46
isocitrate dehydrogenase 46
cathepsin B 45
aldehyde dehydrogenase 44
sphingosine kinase 44
aldehyde dehydrogenase 43
matriptase 43
sialidase 43
myosin light chain kinase 43
cathepsin D 42
prostate-specific antigen 42
thymidylate synthase 42
tissue plasminogen activator 41
TOR 40
MPP 40
thyroid peroxidase 39
aldehyde dehydrogenase 38
TACE 38
aldehyde dehydrogenase 38
aldehyde dehydrogenase 38
elastase 38
histone acetyltransferase 37
TAT 37
ALDH 37
acid phosphatase 35
firefly luciferase 35
complex I 35
CPT 35
caspase-7 34
caspase-7 34
chloramphenicol acetyltransferase 33
ribonuclease 33
ribonuclease 33
CPT 33
ornithine decarboxylase 33
CPT 33
arginase 33
PTPase 32
matriptase 32
neutrophil elastase 31
endonuclease 31
kinesin 30
glyceraldehyde-3-phosphate dehydrogenase 30
glutathione reductase 29
lipoxygenase 29
HK2 28
gamma-glutamyl transpeptidase 28
enolase 28
hyaluronidase 28
DNase 28
hexosaminidase 28
polo-like kinase 1 28
PCP 27
endothelin-converting enzyme 27
furin 27
p80 27
more...
Compound
DNA 7325
Dec 6419
MEK 5768
tyrosine 5536
methionine 4612
Clin 3636
oxygen 2420
calcium 1887
water 1583
TNF 1519
glucose 1327
PEG 1217
MDA 1202
MTT 1153
ATP 1112
serine 1104
PEG 1092
phosphate 947
cAMP 933
threonine 890
acetate 851
MAP 834
sodium 805
nitric oxide 780
HEP 714
cysteine 699
hydrogen 635
arginine 553
lysine 496
ACS 478
ACS 475
sulfate 457
retinoic acid 398
BCR 389
glutamate 389
alanine 386
ABL 385
leucine 375
Insulin 374
Phe 370
iron 359
ethanol 329
GTP 315
zinc 313
GSH 294
GSH 294
salt 286
iodine 282
urea 281
AMP 280
PMA 276
nitrogen 273
Asp 270
NH2 268
His 265
THP 264
THP 264
PLA 262
PMA 247
N-acetylcysteine 247
H2O2 245
potassium 242
Tyrosine 233
bromide 230
TIF 228
TNM 228
galactose 224
Luminal 211
pyrimidine 209
PGE 208
Cardiol 205
pyrimidine 203
Estrogen 195
Estrogen 195
COS 191
proline 183
TEM 182
DAT 181
Gly 179
5-HT 176
Curcumin 171
Pac 167
silver 166
CAM 164
Ang II 162
SDS 162
PGE2 161
Cbl 160
Thyroid 160
methanol 158
cGMP 151
quinazoline 149
quinazoline 149
creatinine 148
ADP 147
tryptophan 145
DDP 145
NMDA 143
copper 141
ammonium 137
Adriamycin 137
ADP 136
ADP 136
ADR 136
Vimentin 135
ASA 133
boron 130
glutamine 127
valine 126
5-FU 126
ICI 126
CO2 120
vitamin D 118
DSM 117
ATF 116
SEE 114
glycerol 114
Collagen 113
formaldehyde 111
ALP 110
hyaluronic acid 108
Angiotensin II 106
NAD 104
SCC 103
tryptophan 102
TPA 101
DFS 100
CAP 100
TPA 99
acetic acid 98
Paclitaxel 97
aspartic acid 97
dUTP 97
silicon 96
Rapamycin 95
DMSO 94
tryptophan 94
tryptophan 94
Panam 93
Tamoxifen 93
Tamoxifen 93
CAT 93
GABA 92
pyridine 92
glutamic acid 91
CAT 91
CAT 91
Ile 90
carbonate 90
GABA 90
TOF 89
aspartic acid 89
MTS 88
MTC 86
Hemoglobin 86
CAP 86
cadmium 85
aspartic acid 85
aspartic acid 84
NAD 83
more...