Gene/Protein Disease Symptom Drug Enzyme Compound
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We have detected transforming activity by a tumorigenicity assay using NIH3T3 cells transfected with DNA from a chronic myeloproliferative disorder patient. Here, we report the cDNA cloning of the corresponding oncogene, designated UFO, in allusion to the as yet unidentified function of its protein. Nucleotide sequence analysis of a 3116bp cDNA clone revealed a 2682-bp-long open reading frame capable of directing the synthesis of a 894 amino acid polypeptide. The predicted UFO protein exhibits characteristic features of a transmembrane receptor with associated tyrosine kinase activity. The UFO proto-oncogene maps to human chromosome 19q13.1 and is transcribed into two 5.0 kb and 3.2 kb mRNAs in human bone marrow and human tumor cell lines. The UFO locus is evolutionarily conserved between vertebrate species. A 4.0 kb mRNA of the murine UFO homolog is expressed in a variety of different mouse tissues. We thus have identified a novel element of the complex signaling network involved in the control of cell proliferation and differentiation.
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PMID:A novel putative tyrosine kinase receptor with oncogenic potential. 183 74

This paper summarizes the development of the concept of metachoric experiences from 1961 onwards. The name of metachoric experience was given to one in which the whole of the environment was replaced by a hallucinatory one, although this may provide a precise replica of the physical world and appear to be completely continuous with normal experience. Prior to 1968 three types of metachoric experiences had been recognized; lucid dreams, out-of-the-body experiences (OBEs) and false awakenings, all of which showed interrelationships. The Institute's 1968 appeal for apparitional experiences led to a recognition that many of these were probably metachoric. This was suggested among other things by certain cases in which the lighting of the whole field of view changes, thus indicating that the experience was completely hallucinatory. The study of apparitions led also to the concept of waking dreams, i.e. completely hallucinatory experiences which may be initiated and terminated without any awareness of discontinuity on the part of the subject. These experiences seem to be capable of considerable apparent extension in time, thus providing a possible explanation of some reports of UFO sightings and of some of the more anomalous experiences of psychical research. In this connection the paper discusses the well-known Versailles experience of Miss Moberly and Miss Jourdain, and a published case of C.G. Jung. In conclusion some of the most obvious similarities and differences between the different types of metachoric experiences are discussed.
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PMID:Waking dreams and other metachoric experiences. 237 88

Luminous phenomena and anomalous physical forces have been hypothesized to be generated by focal tectonic strain fields that precede earthquakes. If these geophysical processes exist, then their spatial and temporal density should be greatest during periods of protracted, localized UFO reports; they might be used as dosimetric indicators. Contemporary epidemiological data concerning the health risks of power frequency electromagnetic fields and radon gas levels (expected correlates of certain tectonic strain fields), suggest that increased incidence (odds ratios greater 1:3) of brain tumors and leukemia should be evident within "flap" areas. In addition the frequency of variants of temporal lobe lability, psychological depression and posttraumatic stress should be significantly elevated. UFO field investigators, because they have repeated, intermittent close proximity to these fields, are considered to be a particularly high risk population for these disorders.
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PMID:Geophysical variables and behavior: LIII. Epidemiological considerations for incidence of cancer and depression in areas of frequent UFO reports. 306 8

A strong temporal correlation was found between the numbers of reports of UFOs (unidentified flying objects) and nearby seismic activity within the Uinta Basin for the year 1967. The numbers of UFO reports per month during this classic UFO flap were correlated 0.80 with the sum of the earthquake magnitudes per month for events within 150 km of the report area. Numbers of UFO reports were not correlated significantly with earthquake activity at distances greater than 150 km but less than 250 km away. The strongest correlation occurred between UFO reports and nearby seismic activity within the same month but not for previous or consequent months. Close scrutiny of daily shifts in epicenters and reports of UFOs indicate that they occurred when the locus of successive epicenters shifted across the area. These analyses were interpreted as support for the existence of strain fields whose movements generate natural phenomena that are reported as UFOs.
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PMID:Geophysical variables and behavior: XXIII. Relations between UFO reports within the Uinta Basin and local seismicity. 398 23

The tectonic strain hypothesis for many reports of UFOs (UFORs), primarily odd luminosities and metallic-looking phenomena, has been criticized on the basis of inadequate data. This reply begins with the distinction between the empirical basis for the association between UFORs and seismic activity, the hypothesis, and laboratory experiments. It is emphasized that criticisms of data should be based upon empirical criteria rather than value judgments about scientific credibility. Multivariate and bivariate analyses have indicated systematic relationships between UFORs and earthquake measures within several different areas and for different historical periods. However, the physical mechanisms for the generation of individual UFO events and their relationship to UFORs require closer examination.
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PMID:Geophysical variables and behavior: XXVI. A response to Rutkowski's critique of the tectonic strain hypothesis for UFO phenomena. 400 Aug 76

The analysis is completed. Through a series of propositions and hypothesized links between the reporting of UFO sightings and a particular kind of social position, the utility of social theory as a basis for explaining phenomena presumed to be in the domain of the physical sciences has been demonstrated. Nothing in the data rejects the possibility that some individuals have, in fact, seen objects propelled from another solar system or that all observations are of ill-understood or misperceived terrestrial phenomena. Empirical science, particularly social science, does not address itself to ultimate truth. What has been attempted here is the employment of a sociological theory to account successfully for observed regularity in patterns of UFO sightings. Another and reasonable, though not necessarily mutually exclusive, procedure for organizing social data might provide an equal degree of explanatory consistency. This analysis merely emphasizes the need to utilize such approaches outside the confines of laboratory groups and the more convenient and established domains of social science. Our analysis has presented just one application of sociological theory to the complex interplay among quasi-scientific phenomena, physical science knowledge, and human behavior in society.
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PMID:Status inconsistency theory and flying saucer sightings. 552 29

v-ryk is the oncogene in the avian acute oncogenic retrovirus RPL30, its cellular counterpart, c-ryk, is described in this report. To avoid the confusion caused by another gene with the same name, we renamed v-ryk to be v-eyk, thereby changing the proto-oncogene's name to c-eyk. c-eyk is expressed highly in chicken spleen and moderately in many other tissues including embryonic tissues. Its cDNA is 3061 base pairs encoding a receptor-type protein tyrosine kinase (PTK) of 974 amino acids. Compared to c-Eyk, v-Eyk is a truncated PTK lacking the extracellular and transmembrane regions of c-Eyk in addition to two amino acid changes. c-Eyk has two C2-type Ig domains and two FN-III domains in its extracellular region, forming a new subfamily of receptor-type PTK together with UFO/Axl/Ark. As suggested by Ig/Fn-III domains in many cell adhesion molecules, this subfamily of PTK may mediate cell-cell interaction.
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PMID:The proto-oncogene of v-eyk (v-ryk) is a novel receptor-type protein tyrosine kinase with extracellular Ig/GN-III domains. 750 87

The ARK (AXL, UFO) receptor is a member of a new family of receptor tyrosine kinases whose extracellular domain contains a combination of fibronectin type III and immunoglobulin motifs similar to those found in many cell adhesion molecules. ARK mRNA is expressed at high levels in the mouse brain, prevalently in the hippocampus and cerebellum, and this pattern of expression resembles that of adhesion molecules that are capable of promoting cell aggregation through homophilic or heterophilic binding. We report here the ability of the murine ARK receptor to mediate homophilic binding. Expression of the ARK protein in Drosophila S2 cells induces formation of cell aggregates consisting of ARK-expressing cells, and aggregation leads to receptor activation, with an increase in receptor phosphorylation. Homophilic binding does not require ARK tyrosine kinase activity, since S2 cells expressing a receptor in which the intracellular domain was deleted were able to undergo aggregation as well as cells expressing the wild-type ARK receptor. Similar results were obtained with NIH 3T3 and CHO cells expressing high levels of ARK, although in this case ARK expression appeared to be accompanied by constitutive activation. The purified recombinant extracellular domain of ARK can induce homotypic aggregation of coated fluorescent beads (Covaspheres), and this protein can also function as a substrate for adhesion by S2 and NIH 3T3 cells expressing ARK. These results suggest that ARK represents a new cell adhesion molecule that through its homophilic interaction may regulate cellular functions during cell recognition.
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PMID:The receptor tyrosine kinase ARK mediates cell aggregation by homophilic binding. 782 30

Aberrant function of protein kinases has been implicated in the development of melanoma. In an effort to define the molecular events involved in initiation and progression of this malignancy, we used RT-PCR to identify protein kinases in both normal and transformed melanocytes. Collectively, we identified seven clones corresponding to previously characterized protein kinases (JAK-1, TYK02, AXL/UFO, IGF1-R, KDR and FER) as well as the recently identified MLK-3/PTK1 protein kinase. Northern analysis was used to determine the expression pattern of each protein kinase in both normal melanocytes and a variety of melanoma cell lines. Relatively abundant levels of UFO/AXL and KDR mRNAs were observed in a subset of the melanoma cell lines whereas most of the remaining protein kinases were expressed at similar levels in both normal and transformed melanocytes.
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PMID:Protein kinases in normal and transformed melanocytes. 785 16

We report the identification of ligands for Tyro 3 (alternatively called Sky, rse, brt, or tif) and Axl (alternatively, Ark or UFO), members of a previously orphan family of receptor-like tyrosine kinases. These ligands correspond to protein S, a protease regulator that is a potent anticoagulant, and Gas6, a protein related to protein S but lacking any known function. Our results are reminiscent of recent findings that the procoagulant thrombin, a protease that drives clot formation by cleaving fibrinogen to form fibrin, also binds and activates intracellular signaling via a G protein-coupled cell surface receptor. Proteases and protease regulators that also activate specific cell surface receptors may serve to integrate coagulation with associated cellular responses required for tissue repair and growth, as well as to coordinate protease cascades and associated cellular responses in other systems, such as those involved in growth and remodeling of the nervous system.
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PMID:The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. 786 73


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