Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.1 (ERK)
 95,504 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The applicability of clinical examination was studied in women with symptoms of medium-advanced or advanced primary gestosis of subpopulation of T lymphocytes (CD3+, CD4+, CD8+) in the peripheral blood. Also studied was the usefulness of the proliferative activity of lymphocytes in in vitro cultures: spontaneous and mitogenic (PHA, ConA, PWM)--in the environment of fetal calf serum (FCS) and autologous sera: heat-inactivated and heat-non-inactivated. It has observed that the percentages of particular T Lymphocyte subpopulations and the proportion of CD4+ lymphocytes to CD8+ lymphocytes in the peripheral blood and the mitogenic activity of the heat-non in activated autologous serum in the test of lymphocyte spontaneous blastic transformation reveal a correlation with an enhancement of particular clinical symptoms of EPH gestosis and with the birth condition of newborns.
Ginekol Pol 1992
PMID:[Certain factors of cellular immunity in clinical evaluation of women with EPH gestosis symptoms]. 130 36

The spontaneous proliferative activity of lymphocytes and CD4+/CD8+ ratio has been estimated in normal and EPH gestosis-affected pregnancy; also the effects of autologous and allogenic sera on this lymphocyte activity was evaluated. Although in normal pregnancy there was a very low CD4+/CD8+ ratio, the spontaneous proliferative activity of lymphocytes and the effects of autologous sera exerted thereupon were the same in either healthy pregnant women or in non-pregnant controls, what indicates a normal cellular immunity in physiological pregnancy. In gestosis an increased proliferative activity of lymphocytes and very high CD4+/CD8+ ratio was observed, when referred to non-pregnant controls. The serum of normal pregnant women did not reveal any immunosuppressive features against the activity of both autologous lymphocytes and gestosis--affected pregnancy, whereas it clearly inhibited the lymphocyte proliferation in non-pregnant controls. A different model of the autologous sera effects on the lymphocyte activity in gestosis women--when compared with the other examined women--is an evidence for altered immuno-modulating parameters of the serum in question.
Ginekol Pol 1992
PMID:[Spontaneous proliferative activity of lymphocytes in normal and EPH gestosis complicated pregnancy]. 130 37

Among 30 pregnant women with EPH-gestosis activity of myeloperoxidase was significantly decreased and activity of acid phosphatase was not much increased. Results of scientific researches can confirm the fact of weakness of anti-infection immunity among women with EPH-gestosis in compare with healthy pregnant women.
Ginekol Pol 1992 Jun
PMID:[Activity of acidic granulocyte phosphatase and myeloperoxidase among women with EPH gestosis]. 133 34

The results of surgical treatment of 195 metacarpo-phalangeal joints in 132 rheumatoid patients were evaluated. The indications for each of three operative methods were presented with clinical assessment and Larsen, Dahle, Eek scale of radiological changes taken into consideration. The results of 137 synovectomies, 32 joint replacements and 24 arthroplasties in 88% were rated as good and fair. The advantages of early synovectomy as well as joint replacement in advanced arthritis were underlined.
Chir Narzadow Ruchu Ortop Pol 1990
PMID:[Surgical treatment of metacarpo-phalangeal joints in patients with rheumatoid arthritis]. 136 57

Conduction defect are known to delay and fragment the ecg signal and may be expected to cause changes on the signal-averaged ecg that mimic ventricular late potentials. The aim of our study was to asses whether signal-averaged ECG (SAE) identify patients (pts) with sustained ventricular tachycardia (VT) after myocardial infarction (MI) who display right or left bundle branch block (RBBB or LBBB). We studied 23 pts with RBBB and 25 pts with LBBB. SEA was recorded with bidirectional filters at 25-250 HZ and 40-250 Hz using Simson method. The total filtered QRS duration (QRSd), root mean square voltage in the terminal 40ms of the QRS (RMS40) and low amplitude signal duration less than 40uV (LAS40)) were measured. Signal-averaged parameters with a filter at 25-250 Hz were: [table: see text] Signal-averaged parameters with a filter at 40-259 Hz were: [table: see text] In conclusion SAE parameters do not allow separation of pts with sustained VT from pts with RBBB or LBBB after MI. These data indicate that conduction defects have effects on signal-averaged ecg parameters and may result in masking of ventricular late potentials.
Kardiol Pol 1992
PMID:[A method of averaged ECG signal does not identify patients with ventricular tachycardia in disorders of intraventricular conduction]. 158 19

Three cases of EPH-gestosis complicated with liver function and blood coagulation disorders (HELLP syndrome) are presented. The most frequent diagnostic errors and subsequent risk for both mother and fetus have also been discussed. Basing on the available literature, the safest management of pregnancy and delivery is critically assessed.
Pol Tyg Lek
PMID:[Liver function disorders and blood coagulation disorders in the course of EPH gestosis]. 166 67

The influence of cardioplegic arrest (single or multidose cardioplegia) and subsequent long-term cold storage on myocardial high energy phosphate content was studied in 29 dogs divided into 6 groups of experiments. Three cardioplegic solutions were tested: Bretschneider HTK (intracellular-type solution), St. Thomas' Hospital and N.I.H. solutions (both extracellular-type solutions). In group I, II and III single dose cardioplegic arrest with respectively St. Thomas' Hospital, Bretschneider HTK and N.I.H. solutions was carried out and excised hearts were stored at 0.5 degrees C for 24 hours. In group IV-Bretschneider HTK and in group V-N.I.H. solutions were used for cardioplegic arrest and intermittent perfusion of the cooled hearts at 4, 8 and 12 hours of storage (multidose cardioplegia). In group VI, after cardioplegic arrest with Bretschneider HTK solution, different temperatures of storage (0.5 degrees C, 12 degrees C and 18 degrees C) were studied. Myocardial content of ATP and creatine phosphate was evaluated by means of bioluminescence techniques from serial left ventricular biopsies taken prior to aortic cross-clamping and after 1, 2, 3, 4, 5, 6, 8, 10, 12 and 24 hours. In group I ATP was significantly lower than in groups II and III after 6 h (p less than 0.005). After 24 hours of storage ATP-levels were significantly higher (p less than 0.05) after multidose Bretschneider HTK cardioplegia or N.I.H. cardioplegia than after single dose N.I.H. or St. Thomas' cardioplegia. There was no significant difference in ATP content between multidose Bretschneider and multidose N.I.H. cardioplegia.(ABSTRACT TRUNCATED AT 250 WORDS)
Mater Med Pol
PMID:Long-term preservation of donor hearts: the effect of intra- and extracellular-type of cardioplegic solutions on myocardial high energy phosphate content. 213 19

The influence was studied of different diets on the activity of cathepsin D (PSCatD), pepstatin (PIA) and leupeptin (LIA) insensitive acid autolytic activity (AAA), RNA, DNA and protein in skeletal leg muscle (LM) and liver of 37 mice. The diets affected the weight of the liver and content of protein in the liver and LM. The protein:DNA ratio was lowest on high carbohydrate (HC) and commercial (C) diets in both tissues and about 3 times higher in LM than in the liver. The RNA:protein ratio was highest in the high protein-fat (HPF) and recommended (R) diet fed groups. The RNA:DNA ratio was lowest on HC and C diets. In the liver, PSCatD, AAA, LIA were lowest on HPF, and highest on HC diets, but for PIA on high fat-protein (HFP) and C diets, respectively. The highest activities were correlated with the lowest percentage of protein and fat in the diets (low energy diets). For LM, the highest activities were found on a C diet and lowest for PSCatD on HEP but for AAA, PIA, LIA on HC diets. Cathepsin D accounted for about 70% of hemoglobin degradation in the liver and 66% in LM. In AAA, cathepsin D participates in 58.5% and 50.5% in the liver and LM inhibition, respectively, but leupeptin accounted for about 15% and 27% (in the presence of Mg++) of inhibition.
Acta Physiol Pol
PMID:Changes in cathepsin D, acid autolytic activity, RNA, DNA in skeletal muscle and liver of mouse kept on high protein, carbohydrate and lipid diets. 248 68

In 12 dogs the hearts after excision were perfused for 24 hours with Bretschneider HTK cardioplegic solution. Six of these hearts were used only to assess myocardial HEP and ultrastructure during 24 hours of conservation. In the next six dogs orthotopic heart transplantation was performed to evaluate functional outcome after prolonged preservation. After 24 hours of continuous perfusion of the donor heart the ATP level was completely comparable with control, preischemic value. Also ultrastructure of the myocytes was perfectly preserved. All transplanted hearts recovered completely upon reperfusion without a need of inotropic support. Good functional outcome after transplantation was correlated with about 70% of myocardial HEP content and intact ultrastructure of the myocytes. We concluded that continuous perfusion with Bretschneider HTK cardioplegic solution makes successful heart transplantation possible after 24 hours of preservation.
Mater Med Pol
PMID:Successful orthotopic heart transplantation in dogs after 24 hours of continuous perfusion with Bretschneider HTK cardioplegic solution. 251 48

The authors analysed perinatal mortality and the condition of 32 newborns of 30 pregnant women with a severe form of gestosis EPH, who did not react to therapy. In all the women the pregnancy was terminated prematurely between 29th and 37th week (not later than 7 days admission to hospital) because of threat to the fetus, threat to the pregnant woman due to renal failure or threat both to the fetus and the woman. In spite of the fact that the newborns had a lower birth weight in comparison with newborns born in the previous years, the above procedure led to the sixfold reduction of perinatal mortality. Fetal hypotrophia amounted to 43% and was ten times higher than in general population.
Ginekol Pol 1989 Apr
PMID:[Mortality of fetuses and newborns in gestosis EPH]. 280 79


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