Gene/Protein Disease Symptom Drug Enzyme Compound
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In this paper are defined new data about distribution, controlling factors, metabolism and aspects of physiological function of pregnancy-specific beta 1-glycoprotein during the second half of pregnancy. In high-risk pregnancies with diabetes, Rh-incompatibility and intrauterine death SP-1 concentrations in amniotic fluid were significantly increased. By evaluation of maternal serum concentrations of SP-1 in cases of high-risk pregnancies with EPH-gestosis and fetal retardation relevant results could be demonstrated.
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PMID:[Pregnancy-specific beta-1-glycoprotein (SP-1) during the second half of pregnancy]. 42 88

It is a well-known fact that pregnancy and parturition, as well as the post-partum period and puerperium, present special problems in multiparae. Hence, we compared 203 of our multiparae with the total group of 3251 parturients in respect of these parameters in a retrospective study. The results were as follows: Pregnancy of multiparae is characterized by an increased incidence of monosymptomatic or polysymptomatic EPH gestosis and by diabetes mellitus. In multiparae it was considerably less often necessary to induce labour than with the other parturients. There was in increased incidence of premature rupture, meconium-stained fluid, funicular complications, vagino-operative birth and delivery in sectio. Reduced desire to nurse the baby was significant sign in multiparae. There was also a significant increase in stillbirths and in the delivery of children with a birth weight of more than 4000 g. There was no increased incidence of monstrosities.
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PMID:[Pregnancy and parturition in multiparae (retrospective study in 203 patients) (author's transl)]. 43 74

The Deoxycytidyl-Deaminase activity in the plasma of 75 woman with a normal or complicated pregnancy was estimated. The control group consisted of 20 healthy, non-pregnant woman. Only in the cases of pregnancies with trisymptomic toxaemia and chronic kidney diseases high enzyme activities were estimated. There are no timedependent changes in the enzym activity during a normal pregnancy. The estimation of the enzyme activity of DCMP-Deaminase in the plasma seems to be a valuable method for the registration of pregnant woman with classical EPH-Gestosis and chronic kidney diseases.
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PMID:[Desoxycytydil-deaminase activity in obstetrics]. 46 20

The maternal deaths occurring in the Kilimanjaro Christian Medical Center (KCMC), which serves as a supraregional reference hospital for the 5 regions of Northern and Central Tanzania, are reviewed for the 1971-1977 period and avoidable factors are discussed. All deaths occurring within the hospital during pregnancy or the first 6 weeks of the puerperium were included in this survey. Postmortem examination was performed in 35% of the cases. In the remaining cases the diagnosis was made on clinical grounds. During the period under review, there were 10 deaths among 83 cases, a mortality of 12%. The major cause of rupture was obstructed labor associated with a contracted pelvis or abnormal lie. 25% of the patients had had a previous cesarean section scar give way. 2 other deaths were attributed to anesthetic accidents and 1 was probably due to pulmonary embolism. The primary cause of death in the 7 remaining cases was hemorrhage (4) and sepsis (3). If deaths from ruptured uterus are to be avoided, early diagnosis is essential. 1044 cases of moderate and severe EPH gestosis (preeclampsia) were treated in KCMC during the period under review together with 54 cases of eclampsia. There were 5 deaths among the patients with eclampsia, a mortality of 9%. In addition to the 11 sepsis deaths there were 3 others included among the cases of ruptured uterus. There were 4 cases of septic abortion and 3 of those admitted to criminal interference. Preexisting anemia was a complicating factor in 5 cases, all of whom died within 15 minutes of arrival. There were 4 deaths among 251 cases of ruptured ectopic pregnancy. There were 10 deaths associated with cesarean section among 1271 sections peformed during the period under review. Deaths from associated diseases included the following: enterocolitis (12 deaths); renal and hypertensive disease (4 deaths); cardiac disease (2 deaths); anemia (2 deaths); malaria (2 deaths); tuberculous meningitis (2 deaths); and miscellaneous associated conditions (11 deaths).
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PMID:Maternal deaths in the Kilimanjaro region of Tanzania. 47 24

The ultrastructure of normal full-term placentae and of placentae of patients with EPH-gestosis was studied. To minimalize artificial changes puncture biopsies during cesarian section were performed. The main ultrastructural alterations in cases of EPH-gestosis can be summarized as follows: loss of the characteristic three-zonal pattern, increased deposits of fibrinoid, rarefication of microvilli, dilatation of the endoplasmic reticulum and of the Golgi apparatus.
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PMID:Ultrastructure of the syncytiotrophoblast of the human term placenta in EPH-gestosis. 52 88

The courses of the following three groups of pregnancies were studied in the context of 146 women, with twelve years, on average, having elapsed from their first pregnancies: 1. Normal pregnancies without EPH gestosis (58 cases); 2. Pregnancies with EPH gestosis (58 cases); 3. Pregnancies with eclampsia (30 cases). - All clinical findings and statistical calculations were evaluated by means of electronic data processing. - Average systolic and diastolic blood pressures were established in follow-up checks, usually twelve years from pregnancy. They were normal, following normal pregnancies. Statistically secured blood pressures measured from patients with gestosis or eclampsia during their first pregnancy were higher than those recorded from patients in a control group, but pathological values were established in but few cases. - The following, more specialised checks proved or particular importance for an evaluation of EPH gestosis and its effects on liver function following pregnancy: serum electrophoresis, thymol test, SGOT, SGPT, direct and indirect bilirubin, blood and urinary sugar, serum cholesterol, and total fats. - The above results are likely to show that EPH gestosis and its effects are relatively well tolerated by the liver. However, discrete disorders characterised by dysproteinaemia without cellular decay and icterus may occur in certain instances.
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PMID:[Late sequels EPH gestosis (author's transl)]. 53 46

In the period between 1966 and 1977 9,591 children were born at the UFK, Mannheim, and of these 1.008 were operative deliveries (10.5%). Out of these children, 99 of those delivered by section, 39 by forceps, 140 by vacuum and 67 spontaneous births were examined in an alphabetically determined group (R) for mental and motor development. The means used for the follow-up investigation were the Kramer-Binet Intelligence Test, and careful questioning of the parents on their children's early development. No connection between the type of delivery and intelligence quotient could be determined. A mean IQ of 114.4 was found for those delivered by section, 116.6 for those by forceps, and 117.7 for thos delivered by vacuum. The spontaneously-born children had an IQ of 108.7. The IQ results determined were correlated with the following data: EPH-gestosis, alteration in the child's heart sounds, protracted birth and Apga. No significant differences in the intelligence or any delayed motor development could be found in relation to the comparative group.
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PMID:[Psychomotor development of children born operatively by Caesarian section, vacuum or forceps in the period between 3 and 7 years (author's transl)]. 54 86

243 twinpregnancies of the university hospital at Hamburg between 1960 to 1969 have been analysed retrospectively (1960 to 1964 = Group A, 1965 to 1969 = Group B). It was found that the main risk factors of gemellary gravidity are the high rate of born before term babies the high rate of EPH-gestosis, and the high rate of perinatal mortality. 57 respectively 65% of all gemellipara had one or more symptoms of EPH-gestosis. Measured by birth weight (less than 2500 g = pre-term and small for gestational age infants) greater than 50% of the twins of group A and B were of low birth weight. The perinatal mortality of multiple pregnancy of all groups of birth weight was 11.6% in group A and 13.3% in group B. The perinatal mortality of not premature newborn with greater than 2500 g was 10 times lower and has been corrected from 1.1% (group A) to 0.5% (group B). Gemellipara, younger than 20 and elder than 30 years of age, show the maximum rate of perinatal mortality. Twins should be diagnosed in time of pregnancy. This allows pre-term hospitalisation with routine testing of placental function and if necessary prophylactic therapy of immature labour. This offers more promise to prevention of prematurity and leads to progress satisfactorily with multiple pregnancy.
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PMID:[Can the high percentage of premature twins be reduced? Thoughts based on an analysis of 243 twin births]. 56 Jul 71

805 narrative summaries from pregnancy, delivery and neonatal period were examined to find out factors which might influence physiological jaundice in the newborn period. The normal range of bilirubin is: 70% of all newborn babies have maximum bilirubin levels below 10 mg/100 ml, while 2.6 exceed 16 mg/100 ml as maximum. Under special conditions i. e. prematurity, small for date babies, male sex, very young and very old mother bilirubin is higher that normal. EPH-gestosis, high birth weight, stress during delivery, very small and very big placenta are followed by diminished bilirubin levels. These findings are discussed in detail.
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PMID:[The influence of exogenous and endogenous factors to physiological jaundice during neonatal period (author's transl)]. 56 99

Blood viscosity studies were carried out at regular intervals in 51 patients with normal pregnancy and in 27 patients with high risk pregnancy, i.e. with EPH-gestosis and placental insufficiency. During gestation the relative blood viscosity is significantly increased compared to 15 normal non-pregnant women. At a corrected hematocrit of 45% we found a direct correlation to plasma fibrinogen and to the blood sedimentation rate. Although the whole blood viscosity does not indicate any change in normal pregnant women, there is, however, a viscosity increase in the last trimester of high risk pregnancies. Additionally a mathematical model of the oxygen diffusion in the placental cotyledo demonstrates rapid decrease of the oxygen partial pressure in the maternal intervillous channel if the microcirculation of the "Placenton" is impaired.
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PMID:[Changes in the blood rheology and their influence on the oxygen diffusion in normal and pathological pregnancies (author's transl)]. 57 82


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