Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

---

Query: EC:2.7.10.1 (ERK)
95,504 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The paper examines the allergen specific B-cell response in peripheral blood from patients undergoing immunotherapy with house dust mite extract. The 12 patients were part of a double blind placebo controlled study, and they were treated with either Dermatophagoides pteronyssinus (n = 4), Dermatophagoides farinae extract (n = 3) (Alutard SQ, ALK, Denmark) or placebo (n = 5). Blood was taken every fortnight on day seven after hyposensitization and tested for IgM, IgG, IgA and IgE antibody secreting cells (AbSC) to D. pteronyssinus and D. farinae allergens and for the total number of immunoglobulin secreting cells (IgSC). The data showed a maximum of approximately 120 Der f I+II specific AbSC/10(6) mononuclear cells (MNC). A comparison of specific AbSC to the major allergens of the two house dust mites demonstrated that there was no measurable species specificity in the B-cell response that could be correlated to immunotherapy with either of the two extracts. The specific IgM, IgG, and IgA response to Der f I+II was examined in the placebo (39 measurements) and the actively treated (56 measurements) groups, and the results demonstrated a significant rise in specific IgM and IgA AbSC following immunotherapy. The number of specific IgG AbSC did not change. There was a mean of less than one specific IgE AbSC/10(6) MNC, and no detectable change following the treatment. It is speculated that immunotherapy to inhalant allergens causes the induction of specific IgA AbSC. It would then be these partly differentiated plasma cells that are detected on their way to the bronchial or gut mucosa to exert their protective function mediated by allergen specific secretory IgA.
...
PMID:The allergen specific B-cell response during immunotherapy. 139 64

The introduction deals with the main characteristics of two representatives of high risk pregnancies: diabetes mellitus and EPH gestoses. Particular interest was shown in risks that may occur in pregnant diabetics, with which they must be acquainted. Some theories are given on the pathogenesis of EPH gestoses. The aim of our investigation was to determine the concentration at which immunoglobulins G, M and A pass in cord blood, amniotic fluid and urine, and whether there is a significant difference between control group and among pregnant diabetics or those with EPH gestoses. The investigation was performed by the nephelometric technique on the Immunochemistry Analyzer. Each group consisted of 20 women, with a total of 60. Immunoglobulins A, M and G were determined in the mothers' sera, cord blood or amniotic fluid. IgG was obtained in urine in measurable concentrations. A significant increase of IgG was found in the urine of pregnant diabetics. IgM was significantly increased in the sera of diabetic mothers. IgA was significantly increased in pregnant diabetics, while both high risk pregnancy groups had an increased IgA in cord blood. The values of IgA in amniotic fluid were decreased in the EPH gestoses group in comparison to the group of diabetics. The authors find these variations interesting and feel they should be followed in other high risk pregnancy groups.
...
PMID:[Laboratory study of patients with endemic nephropathy]. 191 48

Humoral and cellular immune response in schistosomiasis was studied pre and post praziquantel therapy. After treatment the mean anti SEA IgM and IgG and anti SWAP IgM levels in all cases showed significant reduction. In patients with high eosinophilic count anti SEA IgE and IgA were statistically decreased. Other specific antibodies showed negligible changes Cellular immune response was not affected.
...
PMID:Humoral and cellular immune response in schistosomiasis pre and post praziquantel therapy. 223 Mar 24

Antitrophoblastic antibodies were assessed by the bond with the antigen of syncytiotrophoblastic membranes according to Davies (ELISA system) in 17 nulligravidae, in 33 men and 70 pregnant women. The pregnancy was normal in 27 women in the Ist and in 32 in the IIIrd trimester, 11 women had signs of EPH gestosis. The incidence of antitrophoblastic antibodies rises significantly with the period of gestation, in women with toxaemia the values are reduced as compared with the group in the third trimester. The authors did not find a relationship between the values of these antibodies and the concurrently assessed level of immunoglobulin IgG, IgA and IgM. Possibilities of the development of toxic immunocomplexes during EPH toxaemia are discussed.
...
PMID:[Circulating antitrophoblast antibodies in normal pregnancy and in EPH gestosis]. 262 53

Complements C3 and C4, IgG, IgM, IgA and properdin factor B (PFB) were determined in maternal blood sera, sera from the umbilical cord and amniotic fluid in the group consisting of 30 healthy pregnant women and 30 patients with EPH gestoses. PFB and IgG were measured in urine, as well. Significant decrease of C3 complement in maternal sera and PFB in urine was found in the group with EPH gestoses, while a slight C4 complement enhancement was recorded in both maternal sera and the blood sera from the umbilical cord. PFB was conspicuously increased in maternal blood sera. IgG level was higher in the blood sera from the umbilical cord in comparison with that found in maternal sera in both groups examined. IgG, IgM and IgA levels were decreased in the group of patients with EPH gestoses in all fluids examined, while IgA level was significantly increased in the sera prepared from the blood from the umbilical cord.
...
PMID:The significant of complement and immunoglobulin determination in healthy pregnant women and patients with EPH gestoses. 323 58

The interlesional production of immunoglobulins and SEA-specific antibodies was examined in vitro in cultured hepatic granulomas isolated from Schistosoma mansoni-infected mice. Vigorous lesions of 8-wk and immunomodulated lesions of 20-wk infected mice were cultured in serum-free medium for 48 hr; the supernatant fluid was concentrated, dialyzed, and tested for immunoglobulins by immunodiffusion. Whereas cultures of vigorous granulomas contained only IgG1, those of immunomodulated lesions yielded IgG1, IgG2a, IgG2b, IgG3, and IgA immunoglobulins. Both types of lesions incorporated 14C-labeled leucine into IgM and IgG class immunoglobulins thus proving intralesional synthesis. The immunoglobulins also had specific anti-SEA activity proven by passive hemagglutination and in vivo PCA test. The kinetics of SEA-specific IgM and IgG antibody-forming granuloma lymphocytes was examined by the plaque assay after the dispersal of the lesions. At 8 wk of the infection the number of IgM antibody-producing lymphocytes was low and that of IgG was negligible. In subsequent weeks both IgM and IgG antibody-forming cells increased in numbers. The IgM producer cells peaked at 12 to 16 wk and by 32 wk they dropped to barely detectable levels. The IgG antibody-producing lymphocytes peaked in numbers in the immunomodulated lesions at 20 wk and also disappeared by 32 wk. The kinetics of the granuloma lymphocytes as well as the magnitude of their response differed from those of splenic cells. Intralesional antibody production may promote antigen sequestration, complex formation, and occasional tissue injury. The participation of locally produced antibodies in the modulation of the granulomatous inflammatory response remains to be established.
...
PMID:Modulation of granulomatous hypersensitivity. IV. Immunoglobulin and antibody production by vigorous and immunomodulated liver granulomas of Schistosoma mansoni-infected mice. 703 55

Mice with a primary infection of Schistosoma japonicum develop high levels of both total immunoglobulins and parasitic-specific antibodies, beginning about 1.5 wk after the onset of oviposition in the host. Radial immunodiffusion demonstrated an 18-fold, fivefold, and threefold increase in the levels of IgG1, IgM, and IgA, respectively, during the course of infection. Schistosoma japonicum-specific antibodies, as measured by an enzyme-linked immunoabsorbent assay, appeared and increased at about the same time as total immunoglobulins, and were predominantly of the IgG1 and IgM classes. The specific/ELISA response to a purified antigen from S. japonicum SEA was distinct from the total specific response to crude SEA. Hemagglutinating antibodies increased at 5 wk PI and remained at high levels for the duration of infection. Specific, circulating IgE measured by PCA appeared 6 wk PI, reaching a peak at 9 wk, and persisted at moderate levels throughout the infection period.
...
PMID:Serologic responses to Schistosoma japonicum: evaluation of total and parasite-specific immunoglobulins during the course of murine infection. 711 81

In pregnant women with EPH gestosis immunoglobulins in the serum, urine, amnionic fluid, and the umbilical cord serum were determined. The complement value was determined only in mother's serum. The control group consisted of pregnant women without any pathologic changes in the course of pregnancy and with a normal delivery. All children were normal. In the sera of pregnant women with EPH gestosis low IgG and IgM and normal IgA value were recorded. The total hemolytic activity of the complement was within normal, while the C3 component values was somewhat decreased. The finding of decreased IgG values could be explained, partly, by the permeability of the kidney and--the increased concentration of IgG in the urine and partly by the IgG binding into immunocomplexes. The decreased IgM values are assumed to be due to the IgM binding into EPH immunocomplexes. Normal complement values in EPH gestosis do not indicate an active immunologic reaction. Of special interest is the increased IgM level in the serum of the umbilical cord of children from women with EPH gestosis, which remains inexplicable but might suggest an intensified immunological challenge in the fetus.
...
PMID:[Immunoglobulins and complement in pregnant women with EPH gestosis (author's transl)]. 733 78

Specific IgA assays by ELISA technique for schistosomal cases of school age children (12-14 years), were performed before and 3 months after praziquantel treatment. Sera of the resistant cases (non-reinfected after chemotherapeutic cure) showed a significant higher titres of anti-soluble egg antigen (anti-SEA) and anti-soluble worm antigen preparation (anti-SWAP) IgA antibodies than that of reinfected schistosomal cases before and 3 months after treatment. Praziquantel therapy insignificantly (P > 0.05) increased anti-SEA and anti-SWAP IgA antibodies in the sera of schistosomal cases and 3 months after treatment. Anti-SEA IgA & IgE anti-SWAP IgA & IgE were correlated positively with each other among schistosomal cases either resistant or reinfected while anti-SEA and anti-SWAP IgA antibody levels of schistosomal cases with eosinophilia were significantly higher than that with normal eosinophilic counts. Anti-SEA IgA antibody titres of schistosomal cases were correlated negatively, before treatment, with intensity of infection but anti-SWAP IgA titres were not, which might indicates that anti-SEA IgA antibodies inhibit schistosomes for egg laying and subsequently pathological complications due to granuloma formation. The higher titres of specific IgA antibody of resistant cases, its positive correlation with IgE and its negative correlation with intensity of infection might support the role of IgA as an essential component of acquired (resistance) immunity to share with IgE in protection of cured schistosomal cases against reinfection.
...
PMID:Human resistance to reinfection with schistosomes. II. Specific IgA titres before & 3 months after praziquantel treatment. 784 15

Selected immunological parameters of peripheral blood leukocytes in 30 tb contracts and control group consisting of 30 healthy blood donors in similar age were examined. All contacts showed the exudate type Mantoux reaction (over 20 mm in diameter) and all revealed normal chest X-ray. No differences between both groups in total T cells, CD4, CD8 counts, CD4/CD8 ratio and in proliferative response to mitogens (PHA and Con A) were found. Tb contacts had the similar serum IgM and elevated IgG and IgA concentrations as compared with the controls. Tb contacts showed depressed granulocyte metabolic activity as measured by CL response to chemostatic peptide N-FORMYL-MET-LEU-PHE (FMLP) in comparison with control subjects.
...
PMID:[Evaluation of selected immunologic parameters in healthy persons infected with mycobacterium tuberculosis bacillus]. 792 Feb 80


1 2 3 4 5 6 7 Next >>

---