Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.10.1 (
ERK
)
95,504
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
LRRC4/
NGL
-2 (
Leucine rich repeat containing 4
/Netrin-G ligand-2), a relatively specific expressed gene in brain tissue, is a member of the LRRC4/
NGL
(netrin-G ligand) family and belongs to the superfamily of LRR proteins. LRRC4/
NGL
-2 regulates neurite outgrowth and lamina-specific dendritic segmentation, suggesting that LRRC4/
NGL
-2 is important for the development of the nervous system. In addition, LRRC4/
NGL
-2 has been identified as a tumor suppressor gene. The overexpression of LRRC4/
NGL
-2 suppresses glioma cell growth, angiogenesis and invasion through complicated signaling regulation networks. LRRC4/
NGL
-2 also has the ability to form multiphase loops with miRNA, transcription factors and gene methylation modification; the loss of LRRC4/
NGL
-2 function may be an important event in multiple biological processes in gliomas. In summary, LRRC4/
NGL
-2 is a critical gene in the normal development and tumorigenesis of the nervous system.
...
PMID:Function and mechanism of tumor suppressor gene LRRC4/NGL-2. 2552 88
