Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.1 (ERK)
 95,504 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The objective of these studies was to set up a reliable radioimmunoassay (RIA) for staphylococcal enterotoxins A, B, and C (SEA, SEB, and SEC) in a food system. Significant differences (95% confidence limits) were obtained between the 0- and 1-ng/ml enterotoxin standards, so the sensitivity of the RIAs was 1 ng/ml. Polystyrene tubes coated with anti-SEB and stored at 4 degrees C were unstable. The percentage of iodinated SEB bound to these tubes decreased at a rate of 0.33%/day, in contrast to the rate of 0.07%/day obtained with tubes prepared the day before the analyses. Satisfactory precision and maximum sensitivity were obtained by using six replicates for each sample and freshly coated tubes. The antisera used for coating the tubes were reused four times and were frozen between coatings. The process of drum drying mashed potatoes containing 1 mug of SEB per g of mashed potatoes inactivated 83% (wt/wt) of the SEB. Statistical quality control parameters were used to insure that RIAs were performing reliably with a sensitivity of 1 ng/ml. Over 450 samples of potato flakes and granules, which represented different production lots from 12 different manufacturers, were examined for SEA, SEB, and SEC. No enterotoxins were detected.
Appl Environ Microbiol 1977 Dec
PMID:Statistical analysis and quality control in radioimmunoassays for staphylococcal enterotoxins A, B, and C. 7 35

Cultured cells (chicken embryo liver cells and rat embryo fibroblasts) were treated with triparanol (MER-29) for various lengths of time. Both types of cells have developed numerous membranous whorls-myeloid bodies in the cytoplasm. Various stages in myeloid bodies development are described. Acid phosphatase activity was cytochemically demonstrated within the myeloid bodies, indicating their lysosmal nature. This activity appeared only at a late stage of the myeloid bodies formation.
Virchows Arch B Cell Pathol 1975 Dec 19
PMID:Myeloid bodies formation in triparanol treated cultured cells. 17 85

Since the brain processings can be expressed by ballistic or ramp systems, the brain entropy is herein analysed in respect to the distributions of the internal ((MS)1) and external messages ((ME)E) conveyed through the sensory systems. In such a context, it is shown that a first partition (through a primary folding) is established between the neural systems involved in the processings related with the external (RSE) and internal (BSI) environments. Indeed, secondary foldings in both RSE and BSI due to non-homogeneities in (MS)E and (MS)1 are discussed. Finally, the results are extended to the neural phenomena during the brain's embriogenic growth.
An Acad Bras Cienc 1979 Dec
PMID:Brain's entropy partitions. 23 87

The delayed intradermal test and migration inhibition tests were used to assess the delayed hypersensitivity in patients with BHF and simple intestinal bilharziasis using SEA. All bilharzial patients gave a positive intradermal test. The specificity of the intradermal test using SEA is demonstrated clearly by the negative response in all control groups.
Tropenmed Parasitol 1979 Dec
PMID:Cell mediated immune (CMI) responsiveness to soluble egg antigen (SEA) and its relation to the occurrence of schistosomal hepatosplenic disease in patients with schistosomiasis mansoni. 53 16

This report addresses the effects of coal-derived trace and radioactive elements. A summary of our current understanding of health and environmental effects of trace and radioactive elements released during coal mining, cleaning, combustion, and ash disposal is presented. Physical and biological transport phenomena which are important in determining organism exposure are also discussed. Biological concentration and transformation as well as synergistic and antagonistic actions among trace contaminants are discussed in terms of their importance in mobility, persistence, availability, and ultimate toxicity. The consequences of implementing the President's National Energy Plan are considered in terms of the impact of the NEP in 1985 and 2000 on the potential effects of trace and radioactive elements from the coal fuel cycle. Areas of needed research are identified in specific recommendations.
Environ Health Perspect 1979 Dec
PMID:Potential health and environmental effects of trace elements and radionuclides from increased coal utilization. 54 Jun 19

The thermal consequences of coal utilization are most meaningfully assessed in comparison with the form of power generation replaced by coal which is most likely nuclear. The different effects are influenced by siting decisions and the intrinsic thermal efficiencies of the two fuel systems. Nuclear power plants discharge 50% more waste Rheat to the atmosphere through cooling towers or to a water body than coal-fired plants. Coal-fired plants require about 2/3 as much water as nuclear power plants. Nearly every property of water is affected nonlinearly by temperature, and biological effects may amplify these changes because protein denaturation takes place more rapidly above 30 degrees C and these high temperatures affect bactericidal and viricidal activity of chlorine compounds. Usually algal populations change from a dominance of diatoms and green algae to dominance by blue-green algae. All organisms experience elevated metabolic rates at higher temperatures which may affect total energy needs, foraging ability, reproduction, migration and susceptibility to disease. Intake structures inevitably draw many organisms into the cooling system of a power plant, but the number and kind are influenced by its location, configuration, and mode of operation. Use of water recirculation systems reduces water use and with it, the number of organisms entrained. Mechanical damage in the cooling system to small organisms is generally low, but fish and their larvae and eggs may be seriously damaged. Discharge effects may also be severe but are generally local. The near field, where there are strong shear velocities and rapid temperature changes are particularly stressful to fish, and stringent limitations on the timing and strength of discharges may be required to reduce these stresses to nondamaging levels. Off-stream cooling systems may increase cloudiness, ground fog, precipitation, temperature and local winds, but these effects generally extend no further than 1000 m even in winter. There is considerable potential for using condenser cooling water for agricultural and aquacultural purposes such as irrigation, frost protection, undersoil heating, greenhouse heating and climate control. However, over the next few decades little of this waste heat is likely to be used creatively. The thermal consequences of implementing NEP are locally serious but do not pose regional problems. Creative use of the waste heat for aquaculture, agriculture, cogeneration, and power for energy intensive industries can be a powerful means of mitigating undesirable effects.
Environ Health Perspect 1979 Dec
PMID:Thermal pollution consequences of the implementation of the president's energy message on increased coal utilization. 54 Jun 23

Indomethacin inhibits prolactin liberating effects by MET-enkefalin-NH2, a synthetic analogue of MET-enkefalin, both in intact and in ovariectomized, estradiol benzoate treated rats. The introduction of PGE1 increases the intensity of this effect. It is therefore possible to suppose that the PGs are involved as intermediaries of the prolactin relasing effect induced by MET-ENH-NH2.
Boll Soc Ital Biol Sper 1979 Dec 15
PMID:[Inhibitory effects of indomethacin on prolactin liberation induced with peptides with opium-like activity]. 54 65

The response to prolonged antigen exposure and the potentiation of airway resistance increase to ACH challenge, after this exposure, were studied on sixteen boxer dogs. One group of animals presented fatigue to A.E. after 3 hours of exposure. This group developed an increased response to ACH aerosol after fatigue to antigen was present. In a second group of dogs, absence of fatigue during prolonged exposure to allergen was observed. A growing tendency of Edyn (as an index of airway resistance) was observed after 5 hours of exposure. The therapeutical influence of bilateral vagus blockade was tested in these last animals. Blockade of nervus vagus released airway obstruction during prolonged allergen exposure and no bronchoconstriction was observed after ACH challenge during blockade.
Res Exp Med (Berl) 1977 Dec 15
PMID:Fatigue of airway obstruction during long-term exposure to allergen aerosol. 59 97

1. Conflicting qualitative evidence exists concerning the effects on chemoreceptor activity of some drugs which influence the cholinergic system. Quantitative evidence has been obtained in the present study which should resolve the conflict. 2. Experiments were performed in pentobarbitone-anaesthetized cats in which the activity of chemoreceptor units in the sinus nerve was used to assess chemoreceptor responses. The effects of drugs on responses to I.A. ACH and NaCN were determined from dose-response data obtained from several animals and expressed as mean dose ratios 3. The chemoreceptor response to ACh was slightly inhibited by atropine, alpha- and beta-bungarotoxin and HC-3, almost completely suppressed by mecamylamine, and markedly potentiated by physostigmine. 4. Concomitant responses to NaCN were unaffected by atropine, beta-bungarotoxin, mecamylamine or physostigmine. There was a slight inhibition following alpha-bungarotoxin and a potentiation after HC-3. 5. The results do not support the theory that ACh is an excitatory sensory transmitter in the carotid body.
J Physiol 1977 Dec
PMID:A quantitative study of the effects of cholinergic drugs on carotid chemoreceptors in the cat. 59 57

Nine patients with advanced cancer who were receiving the methanol extraction residue of BCG (MER-BCG) intradermally or intratumorally underwent biopsies from the injected sites or from locally enlarged lymph nodes. Most preparations showed a chronic granulomatous reaction consisting of lymphocytes, histiocytes, and epithelioid cells as well as either Langhans's or foreignbody type giant cells, or both. The degree of granuloma formation and giant cell infiltration varied. In only one case did the reactions consist merely of chronic lymphocytic and histiocytic inflammation with no granuloma formation. Examination of melanoma nodules injected with MER showed, in addition to granulomas, large numbers of giant cells penetrating the tumour.
J Clin Pathol 1977 Dec
PMID:Granuloma formation in patients after injection of methanol extraction residue (MER-GCG). 60 61


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