Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.10.1 (
ERK
)
95,504
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Human MENA(11a) (hMENA(11a)), an epithelial-associated isoform of the actin binding protein
enabled homolog
(ENAH, also known as mammalian ENA [MENA]), is upregulated and phosphorylated following the activation of human epidermal growth factor receptor (HER) 1,
HER2
, and
HER3
. Here, we reveal a novel role of this isoform in sustaining cell survival and propose hMENA(11a) as a marker of
HER3
activation and resistance to phosphatidylinositol-3-kinase inhibition therapies.
...
PMID:hMENA(11a), a hMENA isoform sending survival signals. 2730 5
