Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.10.1 (ERK)
 95,504 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Psychopathy, while perhaps the earliest and most recognized personality disorder, is the subject of intense debate about its nature and measurement. The most recent proposal on its structural nature suggests that it is a multifaceted construct, made up of at least four dimensions reflecting Interpersonal, Affective, Lifestyle, and Antisocial anomalies (Hare & Neumann, 2005, 2006). These dimensions are significantly interrelated, suggesting that they are indicators for a super-ordinate factor. The nature of this higher-order factor may reflect the unifying feature which comprehensively defines the disorder. To examine this super-factor, the current study used several very large data sets of male (N = 4865) and female (N = 1099) offenders, and forensic psychiatric patients (N = 965), who were assessed with the Psychopathy Checklist-Revised (PCL-R; Hare, 2003). Structural equation modeling results indicated that the four first-order factor dimensions could be explained by a single second-order cohesive super-factor.
 ...
PMID:The super-ordinate nature of the psychopathy checklist-revised. 1749 16

In our article by J. L. Skeem & D. J. Cooke, (2010), we outlined the dangers inherent in conflating the Psychopathy Checklist-Revised (PCL-R; R. Hare, 1991) with psychopathy itself. In their response, R. Hare and C. Neumann (2010) seemed to agree with key points that the PCL-R should not be confused with psychopathy and that criminal behavior is not central to psychopathy; at the same time, they said we provided no clear directions for theory or research. In this rejoinder, we clarify our argument that progress in understanding the unobservable construct of psychopathy hinges upon setting aside procrustean dependence on a monofocal PCL-R lens to test (a) actual theories of psychopathy against articulated validation hierarchies and (b) the relation between psychopathy and crime. In specifying these conceptual and applied directions, we hope to promote constructive dialogue, further insights, and a new generation of research that better distinguishes between personality deviation and social deviance.
 ...
PMID:One measure does not a construct make: directions toward reinvigorating psychopathy research--reply to Hare and Neumann (2010). 2052 70

Currently, there is no standard self-report measure of psychopathy in community-dwelling samples that parallels the most commonly used measure of psychopathy in forensic and clinical samples, the Psychopathy Checklist. A promising instrument is the Self-Report Psychopathy scale (SRP), which was derived from the original version the Psychopathy Checklist. The most recent version of the SRP (SRP-III; D. L. Paulhus, C. S. Neumann, & R. D. Hare, in press) has shown good convergent and discriminate validity and a factor structure similar to the current version of the Psychopathy Checklist (PCL-R; R. D. Hare, 1991, 2003). The analyses in the current study further investigated the viability of the SRP-III as a PCL-R-analogous measure of psychopathy in nonforensic and nonclinical samples by extending the validation process to a community sample. Using confirmatory factor analyses and logistic regressions, the results revealed that a four-factor oblique model for the SRP-III was most tenable, congruent with the PCL-R factor structure of psychopathy and previous research in which the SRP-III was administered to a student sample.
 ...
PMID:Validating the factor structure of the Self-Report Psychopathy scale in a community sample. 2151 88

Previous theory and research on the structural, longitudinal, and genetic nature of psychopathy have provided strong conceptual and empirical evidence that overt antisociality is a component of the psychopathy construct (Hare & Neumann, 2008, 2010; Lynam & Miller, 2012). However, determination of the strength of the association between antisociality and other psychopathic features has not been explored systematically. The current article draws on previously published large North American studies, as well as data from across the globe, to estimate the strength and pattern of the associations between overt antisociality and other psychopathic domains in a diverse set of samples. Structural equation modeling was used to estimate model parameters from samples that had data on either the Psychopathy Checklist-Instruments (PCL-R, PCL: YV, PCL: SV) or self-report assessments that have known latent structures (SRP, B-Scan 360). In addition, two relatively large samples (male offenders and young adult males), assessed with both the PCL-R and the SRP, provided an opportunity to examine the link between antisociality and the other psychopathy domains across different assessment methods. The overall findings indicate that the associations were moderate to strong, depending on the nature of the sample, and clearly indicate that antisociality is a core component of the psychopathy construct.
...
PMID:Antisociality and the Construct of Psychopathy: Data From Across the Globe. 2518 50

An influential neurobiological model of personality is the Reinforcement Sensitivity Theory, which postulates how basic motivational systems (behavioral activation system [BAS], behavioral inhibition system [BIS]) can help account for the development and expression of individual differences in personality. Earlier research has documented a link between psychopathic personality and the BIS/BAS scale (Carver & White, 1994), which was developed to measure the behavioral inhibition and activation systems. However, no studies have examined how latent BIS/BAS factors and the 4 empirically derived Psychopathy Checklist-Revised (PCL-R) psychopathy factors (Hare & Neumann, 2008) are associated across different cultures. In the current study, structural equation modeling was used to determine how the 4 PCL-R factors were able to predict BIS/BAS factors using 2 large independent samples of male offenders (North American N = 908; Swedish N = 242). The results were in line with theory and revealed a negative relationship between the PCL-R Affective factor and the BIS factor as well as positive relationships between the PCL-R Antisocial and Lifestyle factors with the BAS factor. Overall, the results of the current study provide evidence of cross-cultural generalizability for the associations between the PCL-R factors and the BIS-BAS factors. Taken together, the PCL-R psychopathy factors were able to account for meaningful variance in the BIS-BAS factors and further support a dimensional approach to understanding the psychopathy construct across cultures.
 ...
PMID:A latent variable analysis of the Psychopathy Checklist-Revised and behavioral inhibition system/behavioral activation system factors in North American and Swedish offenders. 2586 35

The current study employed both latent variable- and person-centered approaches to examine psychopathic traits in a large sample of sex offenders (N = 958). The offenders, who had committed a range of sexual crimes, had been assessed with the Psychopathy Checklist-Revised (PCL-R; Hare, 2003). Structural equation modeling results indicated that the four-factor model of psychopathy (Hare, 2003; Neumann, Hare, & Newman, 2007) provided good representation of the dimensional nature of psychopathic traits across the sample of offenders, and that the PCL-R factors significantly predicted sexual crimes. In particular, the Affective and Antisocial psychopathy factors each predicted sexually violent crimes. Latent profile analysis results revealed evidence for a 4-class solution, with the subtypes showing distinct PCL-R facet profiles, consistent with previous research. The four subtypes were validated using sexual crime profiles. The prototypic psychopathy subtype (high on all 4 PCL-R facets) evidenced more violent sexual offenses than did the other subtypes. Taken together, the results demonstrate how variable- and person-centered approaches in combination can add to our understanding of the psychopathy construct and its correlates. (PsycINFO Database Record
 ...
PMID:Using latent variable- and person-centered approaches to examine the role of psychopathic traits in sex offenders. 2840 57

Theory and accumulating data suggest systematic heterogeneity among offenders with psychopathic traits. Several empirical investigations converge on the nature of subtypes, but little is known about differences in treatment responsivity. We have used the 4-facet model of the Psychopathy Checklist-Revised (PCL-R) to provide a framework for detecting subtypes. The present study used the full range of PCL-R scores in a sample of male violent offenders (N = 190) to replicate subtypes found in a partly overlapping sample by Neumann, Vitacco, and Mokros (2016), using Latent Profile Analysis (LPA), and subsequently to examine potential differences in treatment responsivity. Four subtypes emerged. Within the prototypical psychopathic group, the distinction between intent-to-treat and completers was crucial. Prototypical psychopathic offenders were significantly more likely to drop out, but completers appeared to proceed through the different phases of treatment in much the same way as the other groups. Clearly, more research is needed to elucidate treatment interfering mechanisms and their associated patient characteristics, particularly for the prototypical psychopathic group. Developing therapeutic strategies to improve treatment compliance is a necessary step in the development of specialized treatment programs for these difficult patients. (PsycINFO Database Record (c) 2018 APA, all rights reserved).
 ...
PMID:Treatment responsiveness of replicated psychopathy profiles. 3027 68

Valid measurement of psychopathic traits in females using the Psychopathy Checklist Revised (PCL-R) continues to be an under researched topic. Previous latent variable and other psychometric studies have raised questions concerning the structure and predictive effects of psychopathic traits in females. New cross-cultural research finds good support for a four-factor model of psychopathy in females and the predictive effects of the psychopathy factors (Declercq, Carter, & Neumann, 2015; Neumann, Hare, & Pardini, 2015). Nevertheless, additional research is needed on females, especially individuals from diverse cultural backgrounds. We investigated the factor structure and construct validity of the PCL-R in a female Hispanic sample (n = 155). Confirmatory factor analysis showed that the four-factor model provided an adequate fit. Furthermore, structural equation modelling revealed significant negative and positive predictive effects, respectively, between general personality (Agreeableness and Conscientiousness), and indifferent/abusive parenting with the broad syndrome of psychopathy.
 ...
PMID:Structural analysis of the PCL-R and relationship to BIG FIVE personality traits and parenting characteristics in an Hispanic female offender sample. 3033 75