Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: EC:2.7.10.1 (ERK)
 95,504 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Since the brain processings can be expressed by ballistic or ramp systems, the brain entropy is herein analysed in respect to the distributions of the internal ((MS)1) and external messages ((ME)E) conveyed through the sensory systems. In such a context, it is shown that a first partition (through a primary folding) is established between the neural systems involved in the processings related with the external (RSE) and internal (BSI) environments. Indeed, secondary foldings in both RSE and BSI due to non-homogeneities in (MS)E and (MS)1 are discussed. Finally, the results are extended to the neural phenomena during the brain's embriogenic growth.
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PMID:Brain's entropy partitions. 23 87

We tested a model of the process of becoming involved with drugs during junior high. The sample included 698 students who were not using alcohol, cigarettes, or marijuana during Grade 7 (T1); the follow-up data points were 12 and 15 months later (T2 and T3). The final model, which predicted 72% of the variance in drug use at T3, provides support for hypotheses drawn from both social and cognitive theories. Weak familial and school attachments fostered use by increasing the likelihood of exposure to pro-drug social influences (drug use offers); weak bonds with school also directly affected cognitive motivations (lower resistance self-efficacy [RSE] and more positive outcome expectancies). In turn, social influences at T1 played a dominant role in initial use at T2, but cognitive motivations were also significant. At T3, prior use assumed the most prominent position. Drug-specific measures of RSE and expected use directly affected later use of that substance. The results indicate that both generic and drug-specific effects are needed to explain adolescent drug use. Implications for prevention programs are discussed.
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PMID:On becoming involved with drugs: modeling adolescent drug use over time. 128 57

One hundred black hospitalized tuberculosis (TB) patients (75 males and 25 females) were interviewed to ascertain levels of depression and self-esteem. The standard of literacy for 65% of the sample was such that they were unable to complete a self-report inventory. Reliability (internal consistency) was good for the 21-item Beck Depression Inventory (BDI: r = 0.79), the 13-item shortened BDI (ABDI: r = 0.76) and the Rosenberg Self-Esteem scale (RSE: r = 0.78). There was a significant positive relationship between the BDI and the ABDI (r = 0.92, P = 0.0001). The recommended ABDI cut-off scores established no depression for 32 patients, mild depression for 22 patients, moderate depression for 38 patients and severe depression for 8 patients. There were significant negative relationships between the BDI and the RSE (r = -0.54, P = 0.0001), and between the ABDI and the RSE (r = -0.56, P = 0.0001). Self-esteem scores dropped in accordance with category of depression, revealing that low self-esteem is a characteristic feature of depression. It was concluded that the ABDI was a reliable, rapid, initial screening device for depression in black persons with low literacy levels.
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PMID:Depression and self-esteem: rapid screening for depression in black, low literacy, hospitalized tuberculosis patients. 143 14

To assess the performance of FLAG and RSE NMR angiography 22 aortoiliac (AI) and 22 femoropopliteal (FP) angiograms in 11 healthy males, mean age 38 +/- 7.6 years, were acquired. The image quality was graded in a blinded fashion by two independent readers. The readers grades were not statistically different (kappa = 0.5696). The representation of diagnostic images was 6/11 FLAG and 8/11 RSE AI as well as 8/11 FLAG and 8/11 RSE FP. On back-to-back comparison six RSE AI and seven RSE FP were graded better than their FLAG counterparts. Although these differences did not achieve a statistical significance RSE NMR angiography provided consistently better images and appears preferable for imaging of the peripheral vascular system in normal subjects.
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PMID:Aortoiliac and femoropopliteal phase-based NMR angiography: a comparison between FLAG and RSE. 223 17

Congenitally deaf college students were asked to generate rhymes to 50 target words. Results of the investigation indicate that it is possible for deaf individuals to develop the sensitivity to the phonologic structure of the words necessary for rhyming: Approximately half of the responses generated correct rhymes. Of these correct rhymes, the majority were orthographically similar to their target (c.g., BLUE-glue and TIE-lie), although 30% were orthographically dissimilar to their targets (e.g., BLUE-through and TIE-sky), indicating an ability to generate rhymes independent of orthographic structure. Errors were analyzed in an attempt to determine the basis on which the subjects generated rhymes. Evidence of both orthographic and speech-related strategies were obtained.
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PMID:Rhyme generation by deaf adults. 270 95

The possible influence of neurogenic factors on respiratory and circulatory responses to continuous static (CSE), rhythmic static (RSE), and dynamic (DE) exercises was studied in 15 healthy young men. Ventilation (VE), oxygen uptake (VO2), cardiac output (Q), and blood pressure (BP) were measured during the steady-state of the exercise. For a given VO2, VE, and respiratory frequency (f) enhanced significantly with increasing frequency of RSE, and for the same frequency, the responses of these variables to RSE were significantly higher than those for DE. Although a similar trend was observed in heart rate (HR) and Q responses to exercises, it was not as strong as for ventilatory responses. These results lead to the conclusion that ventilation and circulation during exercise may be influenced by some neurogenic factors mediated either centrally or peripherally.
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PMID:Neurogenic factors affecting ventilatory and circulatory responses to static and dynamic exercise in man. 368 98

The growth of tick cells in Leibovitz's L--15 medium supplemented with various concentrations of fetal bovine serum (FBS), tryptose phosphate broth (TPB), and tick egg extract (TEE) was evaluated using a protein assay. A continuous cell line from Rhipicephalus appendiculatus (RA 243) was compared with young lines of cells isolated from embryos of R. appendiculatus (RAE 25) and Rhipicephalus sanguineus (RSE 8). We found fetal bovine serum and tryptose phosphate broth both to be essential supplements. The addition of tick egg extract further stimulated growth. The yield of cellular protein in both young and continuous lines of tick cells increased as a function of the concentration of tryptose phosphate broth from 0 to 10%, and fetal bovine serum from 2.5 to 20%. The growth of the RA 243 line correlated negatively with the size of the inoculum and positively with the concentration of fetal bovine serum, as the greatest increase in cell protein was obtained when cells were seeded at a low density into a medium containing 20% fetal bovine serum. The addition of an extract prepared from eggs of R. sanguineus or Hyalomma excavatum improved yields of cultures and promoted cell growth at low population densities. The protein yield increased as a function of tick egg extract concentration, but 0.8% inhibited growth of the RA 243 line. The RA 243 line could be propagated in a medium supplemented with 10% tryptose phosphate broth, 5% fetal bovine serum, and 0.5% tick egg extract.
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PMID:Effect of medium supplements on tick cells in culture. 713 Nov 99

"Sky" is a putative receptor tyrosine kinase predominantly expressed in the brain. Sky, like Axl/Ufo/Ark and c-Eyk, has an extracellular domain composed of two immunoglobulin-like domains and two fibronectin type III domains. Immunoblot analysis using an antibody raised against a C-terminal peptide of Sky identified a 98-kDa Sky protein in COS cells transfected with sky cDNA (COS/sky cells). A 98-kDa protein in the immunoprecipitates with anti-Sky antibody was autophosphorylated on tyrosine, by in vitro kinase reaction. When the lysates of COS/sky cells were immunoprecipitated with anti-Sky antibody and immunoblotted with an anti-phosphotyrosine antibody, a 60-kDa phosphotyrosine-containing protein, in addition to the tyrosine-phosphorylated Sky, was detected. Using the anti-Src antibody, which is reactive to Src, Fyn and Yes, we obtained evidence for an association between the Src family tyrosine kinase and the tyrosine-phosphorylated Sky receptor. These results suggest that the Src family kinase may play an important role in signal transduction of the Sky receptor.
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PMID:Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase. 753 95

Sky (also called Rse, Brt, and Tyro3) is a member of a subfamily of related receptor tyrosine kinases, including Axl/Ufo/Ark and c-Eyk/Mer. We obtained evidence that Gas6 (the product of growth arrest-specific gene 6) is a ligand of the Sky receptor tyrosine kinase. Gas6, but not protein S (an anticoagulant protein structurally similar to Gas6), specifically bound to the soluble form of Sky (Sky-Fc), composed of the extracellular domain of Sky fused to the Fc domain of human immunoglobulin G1. The native and recombinant Gas6, but not protein S, stimulated tyrosine phosphorylation of Sky ectopically expressed in Chinese hamster ovary cells. Stimulation of Sky in response to Gas6 was inhibited by Sky-Fc. The half-maximal concentration of Gas6 that stimulated Sky was about 1 nM. Thus, Gas6 as a ligand for Sky specifically binds to and stimulates Sky receptor tyrosine kinase.
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PMID:Stimulation of sky receptor tyrosine kinase by the product of growth arrest-specific gene 6. 755 88

Fifty-nine patients with occlusive disease of the aorto-iliac and femoro-popliteal arteries were investigated prospectively by intravenous (IV) or intraarterial (IA) digital subtraction angiography (DSA) and magnetic resonance angiography (MRA). This was accomplished using a two-dimensional (2D) Inflow- (59 patients) and a 2D Phase Contrast- (RSE--rapid sequential excitation) sequence (29 patients). The spectrum of pathology included stenoses < 50%, stenoses 50-89%, stenoses 90-99%, occlusions, aneurysms and status following reconstructive surgery. MRA- and DSA-examinations were evaluated by four radiologists. The diagnoses were made by consent decisions of a radiologist and a vascular surgeon based on clinical and radiological findings. Diagnostic performance of IA-DSA was superior to all other imaging modalities. Vascular delineation of 2D Inflow-MRA was comparable to that of IV-DSA. The image quality of RSE-MRA was not adequate for diagnosis. In conclusion, 2D Inflow-MRA is a promising method for evaluating abdominal and peripheral arteriosclerotic disease. Interpretation of MR-angiograms, however, requires profound knowledge of MRA-techniques, X-ray angiography and hemodynamics.
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PMID:Diagnostic performance of digital subtraction angiography (DSA) and magnetic resonance angiography (MRA): preliminary results in vascular occlusive disease of the abdominal and lower-extremity arteries. 771 92


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