Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.10.1 (
ERK
)
95,504
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Neutral endopeptidase (
NEP
; EC 3.4.24.11) efficiently hydrolyses many neuropeptides. To determine the distribution of
NEP
, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of
NEP
in each cell type of human peripheral blood leukocytes. The activity of
NEP
assessed by an
NEP
inhibitor phosphoramidon-sensitive Met5-enkephalin degrading activity was present in neutrophils (59.0 +/- 9.1 pmol/min 10(6) cells); however, the
NEP
activity was virtually absent in mononuclear cells, eosinophils and basophils.
Common acute lymphoblastic leukemia
antigen (CALLA) detected immunocytochemically with three anti-CALLA antibodies, whose amino acid sequence has been shown to be identical with that of
NEP
, was also found only in neutrophils, but not in other blood leukocytes. It is suggested that
NEP
might regulate the neuropeptide-induced activation of human neutrophils.
...
PMID:[Neutral endopeptidase activity in human peripheral blood leukocytes]. 237 83
