Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.1.21 (thymidine kinase)
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Human Gene/Protein
thymidine kinase 12.0
Alpha-tropomyosin 12.0
TK2 protein 12.0
Interferon-induced protein with tetratricopeptide repeats 2 11.0
KLIP1 11.0
Carbamoylphosphate synthetase I 11.0
thymidine kinase-1 11.0
Thymidine kinase 10.8
TK1 10.8
TK2 10.7
LTK 10.6
AMY1C 10.5
TDP-glucose 4,6-dehydratase 10.5
TRAF interacting protein 10.5
MEF2B protein 10.5
thymidylate kinase 10.2
uridine kinase 10.2
neurexophilin 3 10.0
Neurexophilin 1 10.0
truncated progesterone receptor 10.0
TGF-beta activated kinase 10.0
deoxyguanosine kinase 10.0
thymidine kinase 2 9.8
STK1 9.8
CNIB 9.7
NPH2 9.7
MAGE-E1 9.7
RRE1 9.7
dihydrouracil dehydrogenase 9.6
dGK 9.6
arylformamidase 9.6
dTMP kinase 9.5
neurexophilin 1 9.5
deoxycytidine kinase 9.3
dCK 9.3
Cytochrome P450 4B1 9.2
GANC 9.2
Cytoskeleton-associated protein 2 9.2
dCMP deaminase 9.2
Kruppel-type zinc finger 9.0
CCAAT-box-binding transcription factor 9.0
CCDC67 9.0
truncated beta-globin 9.0
HCA1 8.9
dNT2 8.9
GADD45 gamma 8.9
I-TRAF 8.9
TUT1 8.9
thymidylate synthetase 8.8
EAPP 8.7
Deoxycytidine kinase 8.6
TSase 8.6
VIK 8.6
TAOK3 8.6
NBR2 8.6
HSA6 8.6
HSA12 8.6
CRYBP1 8.6
inosine monophosphate dehydrogenase 2 8.5
KA21 8.5
SPBP 8.5
thymidine phosphorylase 8.4
TMEM135 8.3
tolloid-like 2 8.3
NR2B1 8.3
H-2RIIBP 8.3
ZF5 8.3
KHK 8.3
TFDP3 8.3
aprt 8.3
MGR 8.2
chloride intracellular channel 4 8.1
CAT5 8.1
MTGR1 8.1
uridine phosphorylase 8.1
c-myc promoter binding protein 8.0
RP15 8.0
SIN3B 8.0
dNT-2 8.0
MAN2A1 8.0
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Disease
Bovine herpes mammillitis 10.5
Primary herpes simplex 10.5
herpes 2 10.5
Chronic herpes simplex 10.5
uterus hyperplasia 10.0
stage IIIB breast cancer 9.2
Raccoonpox 9.2
hereditary hyperbilirubinemia 9.2
ACV 9.0
HCA1 8.9
herpes simplex 8.9
RP15 8.9
CLL transformation 8.6
Increased drug resistance 8.2
viral enteritis 8.2
Corneal infection 8.2
Mouse Lymphoma 8.1
gliosarcoma 7.9
Swinepox 7.9
Goatpox 7.8
CCV 7.7
mammillitis 7.7
laryngotracheitis 7.6
GALK 7.5
ECA2 7.5
MNGIE 7.4
Fowlpox 7.3
Teratocarcinoma 7.3
herpes 7.2
Galactosialidosis 7.1
Liver regeneration 7.0
Varicella zoster 7.0
Aujeszky's disease 6.9
ocular herpes 6.9
Aujeszky 6.9
vaccinia 6.8
Shope fibroma 6.8
adult NHL 6.8
PGL3 6.8
Direct infection 6.8
HSV infection 6.7
varicella 6.7
DA3 6.6
suicide 6.6
chronic nasopharyngitis 6.6
Lumpy skin disease 6.5
mouse leukemia P388 6.5
Prostate tumor 6.4
preneoplastic state 6.4
pulmonary carcinoid tumor 6.4
RAT 6.3
MDK 6.3
CEM 6.3
salivary gland adenocarcinoma 6.2
cowpox 6.2
relapsed CML 6.2
Rous sarcoma 6.1
latent infection 6.0
Epithelioma 6.0
Acute retinal necrosis 5.9
TTP 5.9
AA2 5.9
EDIM 5.9
HTX 5.9
HTX 5.8
large cell lung cancer 5.7
immunocytoma 5.7
DHD 5.6
fibrous mesothelioma 5.6
HS3 5.6
African swine fever 5.6
Stretches 5.6
DHD 5.6
Herpesvirus infection 5.6
HLP 5.5
congenital immunodeficiency 5.5
Adenovirus 5.5
Posterior capsule opacification 5.5
AT3 5.4
AT3 5.4
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Symptom
Purulent nasal discharge 9.5
breast hyperplasia 6.9
eye discharge 6.0
penile lesion 5.9
peri-menopausal 4.5
Fluctuation 3.8
POA 3.0
swollen joints 3.0
HSA 2.5
neuralgia 2.3
skin irritation 2.0
ophthalmoplegia 1.9
decreased appetite 1.8
hyperoxia 1.7
starvation 1.7
tonic-clonic seizure 1.7
incoordination 1.2
oliguria 1.2
lethargy 1.1
sneezing 1.1
splenomegaly 1.1
flushing 1.0
rhinorrhea 0.9
tachypnea 0.7
hepatomegaly 0.5
bone pain 0.4
colic 0.4
functional recovery 0.3
exertional dyspnea 0.3
anorexia 0.3
diarrhea 0.2
cerebellar ataxia 0.2
memory loss 0.2
hemiplegia 0.1
chills -0.0
wheezing -0.2
respiratory distress -0.2
cachexia -0.4
agitation -0.5
erythema -0.6
arthralgia -0.8
hypothermia -1.0
syncope -1.1
seizures -1.4
nausea -1.5
back pain -1.5
sleepiness -1.6
acidity -1.8
ataxia -1.9
vomiting -1.9
weakness -2.2
pain -2.4
discomfort -2.4
discomfort -2.5
analgesia -2.7
collapse -2.8
abdominal pain -2.9
anesthesia -3.1
fatigue -3.6
Drug
Carbazeran 10.5
Lobucavir 10.2
Hivid 9.2
Bidisomide 9.0
Eniluracil 8.9
Eniluracil 8.9
Proflavin 8.7
Carbetimer 8.7
Ganciclovir 8.7
Advexin 8.6
5-Iododeoxyuridine 8.6
Acyclovir 8.1
Zovirax 7.8
HPMPC 7.7
PMEA 7.6
Foscavir 7.6
5-Fluorouridine 7.5
Sodium dichloroacetate 7.5
Sodium phenylbutyrate 7.2
Valganciclovir 7.1
Deoxyadenosine 7.1
G418 7.0
Ara-A 6.8
AZT 6.7
AC2 6.6
AZT 6.5
Lenograstim 6.3
PFA 6.1
TFT 6.1
ddI 5.8
Cytidine 5.8
Cidofovir 5.5
Azacytidine 5.5
DNase I 5.3
Aztec 5.3
FSH-beta 5.1
FSH-beta 5.0
Photofrin II 5.0
KAN 4.9
PPA 4.8
AraC 4.8
FSH-beta 4.8
AVC 4.6
Casodex 4.5
Tenofovir 4.4
Tween 60 4.3
Diamminedichloroplatinum 4.3
NOV 4.3
Mutagen 4.3
FCV 4.2
Gel 4.1
-deoxyadenosine 4.0
MRC 4.0
Furan 3.9
Etoposide 3.9
Gramicidin 3.9
CDP 3.8
Norplant 3.8
Glide 3.7
IFN-beta 3.7
Filgrastim 3.6
Vorinostat 3.6
Secretin 3.5
ATV 3.5
Tannic acid 3.5
PMPA 3.4
Filgrastim 3.4
Doyle 3.4
Pemetrexed 3.4
Aminoguanidine 3.3
Retinoic acid 3.3
beta-Galactosidase 3.3
Trifluoperazine 3.2
Photofrin 3.2
Fludarabine 3.2
Emodin 3.2
CPT-11 3.1
TAT 3.1
ICI 3.1
Reserpine 3.1
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Enzyme
thymidine kinase 12.0
dTMPase 11.5
EC 4.1.2.23 11.5
3'-deoxyribonucleotidase 11.0
ADP:dThd phosphotransferase 11.0
Dm-dNK 10.6
EC 2.4.2.2 10.5
thymidylate kinase 10.2
uridine kinase 10.1
deoxyguanosine kinase 10.0
nucleoside phosphotransferase 9.9
deoxyadenosine kinase 9.6
deoxycytidine kinase 9.5
dCMP deaminase 9.2
cytosine deaminase 9.2
STK 9.0
uracil phosphoribosyltransferase 8.7
thymidine phosphorylase 8.4
deoxycytidine deaminase 8.4
thymidylate synthase 8.3
uridine phosphorylase 8.0
galactokinase 8.0
orotate phosphoribosyltransferase 7.8
trans-N-deoxyribosylase 7.7
chloramphenicol acetyltransferase 7.6
kynurenine formamidase 7.6
phosphoserine phosphatase 7.6
succinyl-CoA synthetase 7.5
dUTPase 7.5
ribonucleotide reductase 7.4
ribonucleotide reductase 7.4
dTTPase 7.3
GMP synthase 7.3
CTP synthase 7.1
dCTPase 7.1
dihydropyrimidine dehydrogenase 7.0
hypoxanthine-guanine phosphoribosyltransferase 6.9
dCTP deaminase 6.9
UMP kinase 6.9
hygromycin B phosphotransferase 6.8
dCTP deaminase 6.7
CMP kinase 6.7
firefly luciferase 6.7
adenine phosphoribosyltransferase 6.7
GK2 6.6
guanylate kinase 6.5
proline oxidase 6.5
orotidine-5'-phosphate decarboxylase 6.5
dihydropyrimidine dehydrogenase 6.4
DNA polymerase 6.4
IMP dehydrogenase 6.4
formamidase 6.2
GTI 6.1
phosphopentomutase 6.1
GMP synthetase 5.8
ornithine decarboxylase 5.7
dihydrofolate reductase 5.7
nucleoside diphosphokinase 5.7
cytidine deaminase 5.7
esterase D 5.7
beta-agarase 5.6
3'-phosphatase 5.6
aspartate transcarbamylase 5.6
purine nucleoside phosphorylase 5.6
asparaginyl-tRNA synthetase 5.6
carboxypeptidase G2 5.5
tyrosine aminotransferase 5.5
adenylosuccinate lyase 5.5
beta-galactosidase 5.4
coagulation factor VIIa 5.4
adenosine kinase 5.3
sucrase 5.3
S1 nuclease 5.3
adenylosuccinate synthetase 5.3
methylthioadenosine phosphorylase 5.2
folylpolyglutamate synthetase 5.2
amidophosphoribosyltransferase 5.1
penicillopepsin 5.1
5'-nucleotidase 5.1
oligopeptidase B 5.1
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Compound
Methylmercuric hydroxide 12.0
2,4-diethoxypyrimidine 11.0
Masteril 11.0
Disperse Blue 7 11.0
6-Methoxypurine 10.7
2,6-pyridinediol 10.5
C10H15N3O4 10.5
2,4-pyridinediol 10.5
Ara-T 10.4
5-Fluoro-2'-deoxycytidine 10.0
C24H14 10.0
Decachlorobiphenyl 10.0
Disperse Red 11 9.7
C20H24O6 9.7
cholest-5-en-3beta-yl 9.5
C24H14 9.5
Penciclovir 9.1
Disperse Blue 3 9.0
butyl methanesulfonate 9.0
6-Chloropurine 9.0
Indanthrene Blue RS 8.9
tribromoacetaldehyde 8.9
tribromoacetaldehyde 8.9
Eugeniin 8.7
Epimestrol 8.7
1,5-anhydrohexitol 8.7
3-cyclohexene-1-carboxylic acid 8.7
C.I. Disperse Blue 1 8.7
Trifluorothymidine 8.7
tribromoacetaldehyde 8.6
phosphonoacetic acid 8.2
1,5-anhydrohexitol 8.1
Acyclovir 8.1
Deoxycytidine 8.1
5-methyl-cytidine 8.0
2-methyl-2-cyclohexen-1-one 7.9
2-Acetylpyridine 7.9
NMHE 7.9
Prunetin 7.9
Moxestrol 7.9
TTP 7.8
Deoxyuridine 7.8
Methapyrilene 7.7
5-FC 7.7
Thymidine 7.7
1,5-isoquinolinediol 7.6
Anabasine 7.6
Anabasine 7.5
d4T 7.5
Anabasine 7.5
MMPR 7.5
3-methoxybenzoic acid 7.3
TMP 7.3
FUMP 7.2
4,6-dichloropyrimidine 7.2
Ponasterone A 7.2
dibenzo[def,p]chrysene 7.2
dUMP 7.2
DR-1 7.1
Deoxyadenosine 7.1
ara-AMP 7.1
ara-AMP 7.1
Kryptofix 2.2 7.1
Foscarnet 7.1
PRPP 7.1
4-methyl-1,2,3-thiadiazole 7.0
dCTP 7.0
1843U89 7.0
Vidarabine 6.9
PPA 6.9
ZD1694 6.9
2-iodoethyl 6.8
Blasticidin S 6.8
DHPG 6.8
Salvarsan 6.8
3-methoxybenzamide 6.7
FUDR 6.7
AZT 6.7
4-methylpiperidine 6.6
4-methylpiperidine 6.6
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