Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.1.21 (thymidine kinase)
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Human Gene/Protein
TK2 protein 12.0
thymidine kinase 12.0
Alpha-tropomyosin 12.0
KLIP1 11.0
Carbamoylphosphate synthetase I 11.0
thymidine kinase-1 11.0
Interferon-induced protein with tetratricopeptide repeats 2 11.0
Thymidine kinase 10.8
TK1 10.8
TK2 10.7
LTK 10.6
TDP-glucose 4,6-dehydratase 10.5
AMY1C 10.5
MEF2B protein 10.5
TRAF interacting protein 10.5
thymidylate kinase 10.2
uridine kinase 10.2
TGF-beta activated kinase 10.0
neurexophilin 3 10.0
Neurexophilin 1 10.0
truncated progesterone receptor 10.0
deoxyguanosine kinase 10.0
thymidine kinase 2 9.8
STK1 9.8
RRE1 9.7
CNIB 9.7
MAGE-E1 9.7
NPH2 9.7
dihydrouracil dehydrogenase 9.6
dGK 9.6
arylformamidase 9.6
dTMP kinase 9.5
neurexophilin 1 9.5
deoxycytidine kinase 9.3
dCK 9.3
GANC 9.2
Cytoskeleton-associated protein 2 9.2
Cytochrome P450 4B1 9.2
dCMP deaminase 9.2
Kruppel-type zinc finger 9.0
truncated beta-globin 9.0
CCDC67 9.0
CCAAT-box-binding transcription factor 9.0
HCA1 8.9
dNT2 8.9
I-TRAF 8.9
GADD45 gamma 8.9
TUT1 8.9
thymidylate synthetase 8.8
EAPP 8.7
Deoxycytidine kinase 8.6
TAOK3 8.6
TSase 8.6
VIK 8.6
NBR2 8.6
HSA12 8.6
HSA6 8.6
CRYBP1 8.6
inosine monophosphate dehydrogenase 2 8.5
KA21 8.5
SPBP 8.5
thymidine phosphorylase 8.4
NR2B1 8.3
H-2RIIBP 8.3
KHK 8.3
tolloid-like 2 8.3
ZF5 8.3
TMEM135 8.3
TFDP3 8.3
aprt 8.3
MGR 8.2
chloride intracellular channel 4 8.1
CAT5 8.1
MTGR1 8.1
uridine phosphorylase 8.1
dNT-2 8.0
c-myc promoter binding protein 8.0
MuD 8.0
SIN3B 8.0
MAN2A1 8.0
RP15 8.0
UPRT 8.0
HAT 8.0
galactokinase 8.0
myocyte-specific enhancer factor 2 8.0
NRE-binding protein 8.0
thymidylate synthase 7.9
ICMT 7.8
FGAM synthetase 7.8
ATFa 7.8
hCS-L 7.8
HM5 7.8
alpha 1-chimaerin 7.7
RAB9A 7.7
high mobility group 1 protein 7.7
GALK 7.7
TNF-induced protein 7.7
mitochondrial uncoupling protein 1 7.7
mutated in colorectal cancers 7.6
HOX2 7.6
alpha3A 7.6
retinoic acid responsive 7.6
CLL1 7.6
G protein mRNA 7.6
Hox-1.4 7.6
TARS 7.6
CDC14B 7.6
pyrroline-5-carboxylate reductase 7.6
phosphoserine phosphatase 7.6
Interleukin-24 7.5
cathepsin W 7.5
ARIP2 7.5
CRIP 7.5
E2F-2 7.5
ILBP 7.5
TSE1 7.5
Deoxyguanosine kinase 7.5
DNA polymerase-alpha 7.4
Cytidine deaminase 7.4
adenylosuccinate synthase 7.4
GMP synthase 7.4
MNGIE 7.4
SENP5 7.4
G3B 7.4
TSH beta subunit 7.4
ribonucleotide reductase 7.4
TLL1 7.3
immunoglobulin kappa chain 7.3
CTP synthase 7.3
CMP kinase 7.3
methionine adenosyltransferase II 7.3
aldehyde oxidase 1 7.3
TKR 7.3
CALC 7.3
dUTPase 7.2
NPH4 7.2
GPR78 7.2
P5'N-1 7.2
CD34 molecule 7.2
TRE2 7.2
ECaC2 7.2
GCSh 7.2
gcv 7.2
histone H2a 7.2
platelet-derived growth factor A-chain 7.2
UDP-glucuronosyltransferase 2B7 7.2
UMPK 7.2
GK2 7.1
monocyte chemotactic protein-3 7.1
CDA1 7.1
2F1 7.1
nucleoside phosphorylase 7.0
adenylate kinase 2 7.0
TIEG 7.0
ATP1 7.0
HiNF-P 7.0
Early growth response protein 1 7.0
E2F transcription factor 3 7.0
PSMA7 7.0
Uridine phosphorylase 6.9
more...
Disease
Chronic herpes simplex 10.5
Bovine herpes mammillitis 10.5
Primary herpes simplex 10.5
herpes 2 10.5
uterus hyperplasia 10.0
stage IIIB breast cancer 9.2
Raccoonpox 9.2
hereditary hyperbilirubinemia 9.2
ACV 9.0
HCA1 8.9
herpes simplex 8.9
RP15 8.9
CLL transformation 8.6
Increased drug resistance 8.2
viral enteritis 8.2
Corneal infection 8.2
Mouse Lymphoma 8.1
gliosarcoma 7.9
Swinepox 7.9
Goatpox 7.8
CCV 7.7
mammillitis 7.7
laryngotracheitis 7.6
GALK 7.5
ECA2 7.5
MNGIE 7.4
Fowlpox 7.3
Teratocarcinoma 7.3
herpes 7.2
Galactosialidosis 7.1
Liver regeneration 7.0
Varicella zoster 7.0
Aujeszky's disease 6.9
ocular herpes 6.9
Aujeszky 6.9
vaccinia 6.8
Shope fibroma 6.8
adult NHL 6.8
PGL3 6.8
Direct infection 6.8
HSV infection 6.7
varicella 6.7
DA3 6.6
suicide 6.6
chronic nasopharyngitis 6.6
Lumpy skin disease 6.5
mouse leukemia P388 6.5
Prostate tumor 6.4
preneoplastic state 6.4
pulmonary carcinoid tumor 6.4
RAT 6.3
MDK 6.3
CEM 6.3
salivary gland adenocarcinoma 6.2
cowpox 6.2
relapsed CML 6.2
Rous sarcoma 6.1
latent infection 6.0
Epithelioma 6.0
Acute retinal necrosis 5.9
TTP 5.9
AA2 5.9
EDIM 5.9
HTX 5.9
HTX 5.8
large cell lung cancer 5.7
immunocytoma 5.7
DHD 5.6
fibrous mesothelioma 5.6
HS3 5.6
African swine fever 5.6
Stretches 5.6
DHD 5.6
Herpesvirus infection 5.6
HLP 5.5
congenital immunodeficiency 5.5
Adenovirus 5.5
Posterior capsule opacification 5.5
AT3 5.4
AT3 5.4
AT3 5.4
AT3 5.4
AT3 5.4
AT3 5.4
AT3 5.4
AT3 5.4
AT3 5.4
CMD1 5.4
encephalomyelopathy 5.4
herpes labialis 5.4
Friend leukemia 5.4
Peliosis hepatis 5.4
ADA deficiency 5.3
in situ breast cancer 5.3
genital herpes 5.3
Faber 5.3
recurrent NSCLC 5.3
Herpes simplex encephalitis 5.3
TTP 5.3
Malignant glioma 5.3
vaginal infection 5.2
genital infection 5.2
monkeypox 5.2
Superinfection 5.2
mammary tumor 5.1
embryonal carcinoma 5.1
eye cancer 5.1
CAE 5.1
ACTH-dependent Cushing's syndrome 5.0
Tumour necrosis 5.0
CAE 5.0
reticuloendotheliosis 5.0
Alveolar rhabdomyosarcoma 5.0
AIDS-related lymphoma 5.0
refractory cancer 5.0
Askin tumor 5.0
cytomegalovirus 5.0
Trachea 4.9
Trachea 4.9
Lesch-Nyhan syndrome 4.9
Photosensitization 4.9
glioma 4.9
Trachea 4.9
Primary liver cancer 4.9
MCL 4.9
Lymphocytic infiltration 4.8
TAS 4.8
pituitary tumor 4.8
HRA 4.8
CP1 4.8
salivary gland cancer 4.7
hormone refractory prostate cancer 4.7
Rinderpest 4.7
mastopathy 4.7
Frontal lobe 4.7
PSN 4.7
leptomeningeal metastases 4.7
metastatic ovarian cancer 4.6
Alpers 4.6
OCM 4.5
Bianchi 4.5
Epstein 4.5
brain tumor 4.5
neurofibrosarcoma 4.5
adrenocortical cancer 4.5
DBA2 4.5
RAEB-T 4.5
gingivostomatitis 4.5
oophoritis 4.5
Dedifferentiation 4.5
Zinc deficiency 4.4
blepharitis 4.4
TCO 4.4
paramyotonia 4.4
US1 4.4
Vesicular stomatitis 4.3
brain cancer 4.3
keratitis 4.3
CNS tumors 4.3
toxic adenoma 4.3
more...
Symptom
Purulent nasal discharge 9.5
breast hyperplasia 6.9
eye discharge 6.0
penile lesion 5.9
peri-menopausal 4.5
Fluctuation 3.8
POA 3.0
swollen joints 3.0
HSA 2.5
neuralgia 2.3
skin irritation 2.0
ophthalmoplegia 1.9
decreased appetite 1.8
hyperoxia 1.7
starvation 1.7
tonic-clonic seizure 1.7
incoordination 1.2
oliguria 1.2
lethargy 1.1
sneezing 1.1
splenomegaly 1.1
flushing 1.0
rhinorrhea 0.9
tachypnea 0.7
hepatomegaly 0.5
bone pain 0.4
colic 0.4
functional recovery 0.3
exertional dyspnea 0.3
anorexia 0.3
diarrhea 0.2
cerebellar ataxia 0.2
memory loss 0.2
hemiplegia 0.1
chills -0.0
wheezing -0.2
respiratory distress -0.2
cachexia -0.4
agitation -0.5
erythema -0.6
arthralgia -0.8
hypothermia -1.0
syncope -1.1
seizures -1.4
nausea -1.5
back pain -1.5
sleepiness -1.6
acidity -1.8
ataxia -1.9
vomiting -1.9
weakness -2.2
pain -2.4
discomfort -2.4
discomfort -2.5
analgesia -2.7
collapse -2.8
abdominal pain -2.9
anesthesia -3.1
fatigue -3.6
Drug
Carbazeran 10.5
Lobucavir 10.2
Hivid 9.2
Bidisomide 9.0
Eniluracil 8.9
Eniluracil 8.9
Carbetimer 8.7
Proflavin 8.7
Ganciclovir 8.7
5-Iododeoxyuridine 8.6
Advexin 8.6
Acyclovir 8.1
Zovirax 7.8
HPMPC 7.7
PMEA 7.6
Foscavir 7.6
5-Fluorouridine 7.5
Sodium dichloroacetate 7.5
Sodium phenylbutyrate 7.2
Valganciclovir 7.1
Deoxyadenosine 7.1
G418 7.0
Ara-A 6.8
AZT 6.7
AC2 6.6
AZT 6.5
Lenograstim 6.3
PFA 6.1
TFT 6.1
ddI 5.8
Cytidine 5.8
Cidofovir 5.5
Azacytidine 5.5
DNase I 5.3
Aztec 5.3
FSH-beta 5.1
Photofrin II 5.0
FSH-beta 5.0
KAN 4.9
PPA 4.8
AraC 4.8
FSH-beta 4.8
AVC 4.6
Casodex 4.5
Tenofovir 4.4
Tween 60 4.3
Diamminedichloroplatinum 4.3
NOV 4.3
Mutagen 4.3
FCV 4.2
Gel 4.1
-deoxyadenosine 4.0
MRC 4.0
Furan 3.9
Etoposide 3.9
Gramicidin 3.9
CDP 3.8
Norplant 3.8
Glide 3.7
IFN-beta 3.7
Filgrastim 3.6
Vorinostat 3.6
Secretin 3.5
ATV 3.5
Tannic acid 3.5
PMPA 3.4
Filgrastim 3.4
Doyle 3.4
Pemetrexed 3.4
Aminoguanidine 3.3
Retinoic acid 3.3
beta-Galactosidase 3.3
Trifluoperazine 3.2
Photofrin 3.2
Fludarabine 3.2
Emodin 3.2
CPT-11 3.1
TAT 3.1
ICI 3.1
Reserpine 3.1
Leucovorin 3.1
Dihydro 3.0
Orphan 3.0
MDS 2.9
DHT 2.9
Emodin 2.9
Sulpiride 2.8
Urokinase 2.8
Triad 2.8
TTC 2.8
R1881 2.7
Arsenic trioxide 2.7
CCL 2.7
Forskolin 2.7
Phosphatidylserine 2.6
Adenosine deaminase 2.6
Raloxifene 2.5
Estrogens 2.5
GEO 2.4
Silica 2.4
TAC 2.4
Irinotecan 2.4
IL-2 2.3
PTC 2.3
Adenosine triphosphate 2.2
CSF 2.2
EE2 2.1
Sodium nitroprusside 2.1
Bifidobacterium 2.1
Prednisone 2.0
THF 2.0
uPA 2.0
G-CSF 2.0
DHT 1.9
IFN-gamma 1.9
Glycerol 1.9
L-tyrosine 1.8
RFP 1.8
Azithromycin 1.8
Vitamin B12 1.8
DPA 1.7
Pronase 1.7
ZnCl2 1.7
ZnCl2 1.7
BLM 1.6
Meth 1.6
IL-1ra 1.6
Asn 1.5
Growth hormone 1.5
Bortezomib 1.5
Sorafenib 1.5
Growth hormone 1.5
Adriamycin 1.4
Ranitidine 1.4
Ginseng 1.4
Tacrolimus 1.3
ampicillin 1.3
Kenyan 1.3
Bevacizumab 1.3
Docetaxel 1.3
p75 1.1
Theophylline 1.1
ADR 1.0
ROS 1.0
ACT 1.0
caffeine 1.0
Paraffin 0.9
nitroglycerin 0.9
Herceptin 0.9
Fraction 0.7
ROC 0.7
Nitric Oxide 0.7
ETS 0.7
Fluorescein 0.6
Alanine 0.6
lysine 0.6
Rituximab 0.6
ABC 0.5
Vitamin A 0.5
CaCl2 0.4
more...
Enzyme
thymidine kinase 12.0
dTMPase 11.5
EC 4.1.2.23 11.5
ADP:dThd phosphotransferase 11.0
3'-deoxyribonucleotidase 11.0
Dm-dNK 10.6
EC 2.4.2.2 10.5
thymidylate kinase 10.2
uridine kinase 10.1
deoxyguanosine kinase 10.0
nucleoside phosphotransferase 9.9
deoxyadenosine kinase 9.6
deoxycytidine kinase 9.5
dCMP deaminase 9.2
cytosine deaminase 9.2
STK 9.0
uracil phosphoribosyltransferase 8.7
thymidine phosphorylase 8.4
deoxycytidine deaminase 8.4
thymidylate synthase 8.3
uridine phosphorylase 8.0
galactokinase 8.0
orotate phosphoribosyltransferase 7.8
trans-N-deoxyribosylase 7.7
chloramphenicol acetyltransferase 7.6
kynurenine formamidase 7.6
phosphoserine phosphatase 7.6
succinyl-CoA synthetase 7.5
dUTPase 7.5
ribonucleotide reductase 7.4
ribonucleotide reductase 7.4
dTTPase 7.3
GMP synthase 7.3
CTP synthase 7.1
dCTPase 7.1
dihydropyrimidine dehydrogenase 7.0
hypoxanthine-guanine phosphoribosyltransferase 6.9
dCTP deaminase 6.9
UMP kinase 6.9
hygromycin B phosphotransferase 6.8
dCTP deaminase 6.7
CMP kinase 6.7
firefly luciferase 6.7
adenine phosphoribosyltransferase 6.7
GK2 6.6
guanylate kinase 6.5
proline oxidase 6.5
orotidine-5'-phosphate decarboxylase 6.5
dihydropyrimidine dehydrogenase 6.4
DNA polymerase 6.4
IMP dehydrogenase 6.4
formamidase 6.2
GTI 6.1
phosphopentomutase 6.1
GMP synthetase 5.8
ornithine decarboxylase 5.7
dihydrofolate reductase 5.7
nucleoside diphosphokinase 5.7
cytidine deaminase 5.7
esterase D 5.7
beta-agarase 5.6
3'-phosphatase 5.6
aspartate transcarbamylase 5.6
purine nucleoside phosphorylase 5.6
asparaginyl-tRNA synthetase 5.6
carboxypeptidase G2 5.5
tyrosine aminotransferase 5.5
adenylosuccinate lyase 5.5
beta-galactosidase 5.4
coagulation factor VIIa 5.4
adenosine kinase 5.3
sucrase 5.3
S1 nuclease 5.3
adenylosuccinate synthetase 5.3
methylthioadenosine phosphorylase 5.2
folylpolyglutamate synthetase 5.2
amidophosphoribosyltransferase 5.1
penicillopepsin 5.1
5'-nucleotidase 5.1
oligopeptidase B 5.1
myo-inositol-1-phosphate synthase 5.0
prolinase 4.9
formyltetrahydrofolate synthetase 4.9
dihydroorotase 4.9
adenosine deaminase 4.8
S-adenosylmethionine decarboxylase 4.8
adenosine deaminase 4.8
RNase P 4.8
methylenetetrahydrofolate dehydrogenase 4.8
adenylate kinase 4.8
proton-translocating ATPase 4.8
carbamoylphosphate synthetase 4.8
phosphoglycerate kinase 4.8
luciferase 4.7
oxaloacetate decarboxylase 4.7
nucleotidase 4.6
AMP deaminase 4.6
DNase 4.6
ornithine aminotransferase 4.5
deoxyribonuclease 4.5
deoxyribonuclease 4.5
invertase 4.4
GLO 4.4
endonuclease 4.4
HCS 4.4
poly(ADP-ribose) glycohydrolase 4.3
uridyltransferase 4.3
arylamine N-acetyltransferase 4.3
dihydrodiol dehydrogenase 4.2
exonuclease I 4.2
NCED 4.2
guanase 4.2
GAS 4.1
PRPP synthetase 4.1
HVS 4.1
phosphoenolpyruvate carboxykinase 4.1
spermidine/spermine N1-acetyltransferase 4.1
prostate-specific membrane antigen 4.1
MCS 4.0
S-adenosyl-L-homocysteine hydrolase 4.0
nucleoside hydrolase 3.9
phosphoenolpyruvate carboxykinase 3.9
alpha-glucosidase 3.9
MTD 3.8
prolyl hydroxylase 3.8
DNA ligase 3.8
DNA ligase 3.8
TdT 3.7
CPS 3.7
hexokinase 3.7
carboxylesterase 3.7
polynucleotide kinase 3.6
proteinase-3 3.6
argininosuccinate synthetase 3.6
tryptophanase 3.6
prostate-specific antigen 3.6
phosphoenolpyruvate carboxykinase 3.6
topoisomerase 3.6
lactase 3.6
phosphomannose isomerase 3.6
ACAT 3.5
fructokinase 3.5
pyruvate kinase 3.5
PRE 3.5
microsomal epoxide hydrolase 3.4
topoisomerase 3.4
MDH 3.4
TSA 3.4
Thy1 3.4
arginase 3.3
methionine synthase 3.3
deaminase 3.3
reverse transcriptase 3.3
MDH 3.3
tryptophan 2,3-dioxygenase 3.3
PTR 3.3
sucrase-isomaltase 3.3
choline kinase 3.3
BMT 3.3
PDK1 3.2
more...
Compound
Methylmercuric hydroxide 12.0
Masteril 11.0
Disperse Blue 7 11.0
2,4-diethoxypyrimidine 11.0
6-Methoxypurine 10.7
2,4-pyridinediol 10.5
C10H15N3O4 10.5
2,6-pyridinediol 10.5
Ara-T 10.4
Decachlorobiphenyl 10.0
C24H14 10.0
5-Fluoro-2'-deoxycytidine 10.0
C20H24O6 9.7
Disperse Red 11 9.7
cholest-5-en-3beta-yl 9.5
C24H14 9.5
Penciclovir 9.1
Disperse Blue 3 9.0
6-Chloropurine 9.0
butyl methanesulfonate 9.0
tribromoacetaldehyde 8.9
Indanthrene Blue RS 8.9
tribromoacetaldehyde 8.9
C.I. Disperse Blue 1 8.7
3-cyclohexene-1-carboxylic acid 8.7
Epimestrol 8.7
1,5-anhydrohexitol 8.7
Eugeniin 8.7
Trifluorothymidine 8.7
tribromoacetaldehyde 8.6
phosphonoacetic acid 8.2
1,5-anhydrohexitol 8.1
Acyclovir 8.1
Deoxycytidine 8.1
5-methyl-cytidine 8.0
Prunetin 7.9
2-Acetylpyridine 7.9
Moxestrol 7.9
NMHE 7.9
2-methyl-2-cyclohexen-1-one 7.9
TTP 7.8
Deoxyuridine 7.8
Methapyrilene 7.7
5-FC 7.7
Thymidine 7.7
1,5-isoquinolinediol 7.6
Anabasine 7.6
Anabasine 7.5
d4T 7.5
Anabasine 7.5
MMPR 7.5
3-methoxybenzoic acid 7.3
TMP 7.3
FUMP 7.2
4,6-dichloropyrimidine 7.2
Ponasterone A 7.2
dibenzo[def,p]chrysene 7.2
dUMP 7.2
DR-1 7.1
Deoxyadenosine 7.1
ara-AMP 7.1
ara-AMP 7.1
Kryptofix 2.2 7.1
Foscarnet 7.1
PRPP 7.1
4-methyl-1,2,3-thiadiazole 7.0
dCTP 7.0
1843U89 7.0
Vidarabine 6.9
PPA 6.9
ZD1694 6.9
Blasticidin S 6.8
2-iodoethyl 6.8
DHPG 6.8
Salvarsan 6.8
3-methoxybenzamide 6.7
FUDR 6.7
AZT 6.7
4-methylpiperidine 6.6
4-methylpiperidine 6.6
4-methylpiperidine 6.6
BUdR 6.6
Theaflavin 6.5
ICRF 159 6.5
ICRF 159 6.5
ICRF 159 6.5
Aminopterin 6.5
dGTP 6.5
Ara-A 6.5
dCDP 6.4
PMEA 6.4
Oxyresveratrol 6.4
Tiazofurin 6.4
PMEG 6.4
CB 1954 6.3
3-Deazaneplanocin 6.3
Cyd 6.2
Uridine 6.2
TIF 6.2
dUDP 6.2
PTSM 6.2
IDU 6.1
2-NP 6.1
H-69 6.1
TDP 6.1
2-butenyl 6.1
Potassium bromate 6.0
dATP 6.0
TFT 6.0
2-butenyl 6.0
Disperse Red 1 6.0
Diflubenzuron 6.0
TMP 5.9
TMP 5.9
Valacyclovir 5.9
TMP 5.8
Dibromodulcitol 5.8
dCMP 5.8
IDC 5.7
4-phenylpiperidine 5.7
hexitol 5.7
hexitol 5.7
Mimosine 5.7
2-NP 5.7
Cidofovir 5.7
hexitol 5.6
pyrimidine 5.6
Deoxyguanosine 5.6
Mimosine 5.6
pyrimidine 5.6
dGDP 5.6
beta-tocopherol 5.6
Iodo 5.6
DCH 5.5
2(5H)-furanone 5.5
Terazosin 5.5
5-Methylcytosine 5.5
WR-1065 5.4
FUR 5.3
hexanamide 5.3
1,2-dimethylhydrazine 5.2
Hydroxyurea 5.2
Puromycin 5.2
Didanosine 5.2
N-F 5.1
Thymine 5.1
2,5-dihydrofuran 5.1
Piperidine 5.0
PC-2 5.0
3TC 5.0
6-Thioguanine 5.0
A 150 5.0
2,2,4-trimethylpentane 5.0
uridine 5.0
dihydrofolate 4.9
WY-14,643 4.9
Captan 4.9
CAT 4.9
CAT 4.9
Dibutyryl cyclic AMP 4.9
more...