Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.21 (
thymidine kinase
)
7,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The potential of unleaded gasoline and
2,2,4-trimethylpentane
to induce gene locus mutation and sister-chromatid exchange in human lymphoblasts in vitro was determined. Neither unleaded gasoline, at its maximum tolerated concentration in the medium, nor
2,2,4-trimethylpentane
, at its limit of solubility, induced mutation at the
thymidine kinase
locus. Negative results were seen both in the presence and absence of a rat liver homogenate metabolizing system. Sister-chromatid exchange analyses of the cultures treated with unleaded gasoline and
2,2,4-trimethylpentane
were also negative. Therefore the carcinogenicity and nephrotoxicity of unleaded gasoline and
2,2,4-trimethylpentane
observed in vivo are not correlated with any marked genotoxicity in these in vitro tests.
...
PMID:Assessment of the genotoxic potential of unleaded gasoline and 2,2,4-trimethylpentane in human lymphoblasts in vitro. 394 56
