Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.21 (
thymidine kinase
)
7,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Ectopic pituitary isografts (EPI) have been found to induce a high incidence of uterine
adenomyosis
in SHN mice. All the SHN mice given EPI in the right uterus at 40 days of age developed uterine
adenomyosis
, and more than 80% of mice showed the genesis of subserosal nodules, an advanced state of
adenomyosis
, 65 days after EPI. Activities of both thymidylate synthetase and
thymidine kinase
, i.e. DNA-synthesizing enzymes in de novo and salvage pathways of pyrimidine metabolism, respectively, were significantly increased in EPI-induced uterine
adenomyosis
to approximately 2-fold those in normal control uteri. Bromodeoxyuridine-immunoreactive cells were regarded as the cells in S phase, and the number in the endometrial epithelium and stroma in EPI-induced uterine
adenomyosis
was more than 1.5-fold that in normal control uteri. EPI may affect the genesis of uterine
adenomyosis
generally, but not locally, because there were no differences between the right uterus with EPI and the left without EPI in the incidence of
adenomyosis
, histology or DNA-synthesizing enzyme activities.
...
PMID:Increase of DNA synthesis in uterine adenomyosis in mice with ectopic pituitary isograft. 144 89
