Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.21 (
thymidine kinase
)
7,561
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Herpes simplex virus type 1 was isolated from nine patients with herpes labialis who were not previously exposed to any antiviral agent. A significant variation in the growth of these isolates in
BSC1
cells in the presence of 5-iodo-2'-deoxyuridine and acyclovir was observed. One of the isolates was highly resistant to 5-iodo-2'-deoxyuridine and acyclovir and failed to induce significant activity of
thymidine kinase
in cultures. Herpesvirus reisolated from the same patient 3 1/2 years later did not show significant changes in its resistance to acyclovir, suggesting that the patient has a latent infection with a drug-resistant virus.
...
PMID:Isolation and characterization of herpes simplex virus resistant to nucleoside analogs. 165 55
