Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.1.1 (hexokinase)
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Human Gene/Protein
ATP:D-hexose 6-phosphotransferase 12.6
hexokinase 12.6
HKDC1 protein 12.6
GPR107 protein 12.6
EIF-2B 12.6
Hexokinase type I 12.4
hexokinase III 12.2
Hexokinase-2 12.2
Hexokinase 11.6
solute carrier family 2 (facilitated glucose transporter), member 3 11.6
GLUT-9 11.6
arrestin domain containing 4 11.6
hexokinase 4 11.6
G6d 11.6
kelch-like 12 11.6
hHK1 11.6
NADH dehydrogenase (ubiquinone) Fe-S protein 2 11.6
Kelch-like protein 7 11.6
Hexokinase III 11.6
hexokinase 3 11.5
HKDC1 11.2
HKII 11.1
N-Acetylglucosamine kinase 11.0
Hexokinase II 10.8
hexokinase 1 10.8
Nucleoside diphosphokinase 10.8
Kelch-like protein 12 10.6
HKI 10.5
6-phosphofructokinase 10.4
KID-1 10.4
ARRDC4 10.4
HK4 10.4
Hexokinase 1 10.4
glucose transporter 8 10.3
phosphofructokinase 10.3
Multiple inositol polyphosphate phosphatase 10.2
ORP-1 10.2
PHLPPL 10.2
LY6/PLAUR domain containing 4 10.2
phosphorylase, glycogen 10.1
Glucokinase 10.1
hexokinase II 10.1
HK3 10.1
phosphofructokinase 1 10.0
glucokinase 10.0
fructokinase 10.0
Lactose synthase 10.0
GPR107 9.9
GlcNAc kinase 9.8
fructose-bisphosphatase 9.8
ATP-dependent glucokinase 9.8
GIN1 9.8
pyruvate kinase 9.7
phosphoglyceromutase 9.7
HK1 9.6
hexokinase 2 9.6
ADP-dependent glucokinase 9.4
Fructose-bisphosphate aldolase 9.4
Glucose kinase 9.4
VDAC-2 9.4
SC13 9.4
ECRG1 9.4
stp2 9.4
sideroflexin 9.4
M/SCHAD 9.4
Phosphofructokinase 9.3
bisphosphoglycerate mutase 9.3
glycerokinase 9.3
FAM129A 9.2
Phosphoglucomutase 9.1
ATP:glycerol 3-phosphotransferase 9.1
phosphoglucose isomerase 9.1
fructose-1,6-bisphosphatase 9.1
VDAC1 9.0
glycolytic enzyme 9.0
Voltage-dependent anion channel 9.0
6-phosphogluconate dehydrogenase 9.0
VDAC 9.0
NAGK 9.0
GalNAc kinase 9.0
more...
Disease
Hexokinase deficiency 12.6
Chronic hemolytic anemia 10.2
HPLE 10.0
CLL variants 10.0
GST6 8.8
sideroblastosis 8.7
fructosuria 8.6
trisomy 10p 8.4
metastatic papillary thyroid cancer 8.0
Type V hyperlipoproteinemia 7.9
Pyridoxine deficiency 7.8
Biotin deficiency 7.6
pyruvate kinase deficiency 7.5
Disuse atrophy 7.4
pediatric liver cancer 7.2
Glycerol kinase deficiency 7.1
MODY2 7.1
preneoplastic state 6.9
Erythroleukemia 6.9
Hers 6.9
Mitochondrial DNA depletion 6.8
nervous disorder 6.7
erythroblastopenia 6.7
hereditary nonspherocytic hemolytic anemia 6.6
recurrent thyroid cancer 6.6
Parry 6.5
BHD 6.3
lobomycosis 6.0
renal glycosuria 5.9
Lederer 5.9
BHD 5.8
congenital hemolytic anemia 5.8
diphyllobothriasis 5.8
disorders of carbohydrate metabolism 5.7
viral carcinogenesis 5.6
amebic colitis 5.6
GHD 5.5
Peritoneum 5.5
Peritoneum 5.5
Jejunum 5.4
Pleura 5.3
lung neoplasm 5.3
Pleura 5.3
Krukenberg tumor 5.2
SPS 5.2
choroid plexus carcinoma 5.0
Insulinoma 4.9
nagana 4.9
paramyotonia 4.9
eosinopenia 4.9
Small intestine 4.9
fibrocystic breast disease 4.9
MERRF 4.9
diabetic coma 4.9
diabetic cataract 4.8
SPS 4.8
thalassemia minor 4.8
TNS 4.8
neurogenic hypertension 4.8
river blindness 4.7
MPE 4.7
vitamin B6 deficiency 4.7
insulinoma 4.7
Carcinosarcoma 4.6
Adenoma 4.6
Adenoma 4.6
Enzyme inhibition 4.6
yaws 4.6
fibrocystic disease 4.6
Testis 4.6
Testis 4.6
SME 4.5
AHL 4.5
PMS 4.5
hyperglycemia 4.5
G6PD deficiency 4.5
hereditary persistence of fetal hemoglobin 4.4
HMS 4.4
amebiasis 4.3
hyperinsulinemia 4.3
more...
Symptom
Anoxia 5.0
asterixis 4.9
testicular pain 4.1
starvation 4.1
POA 3.5
Decreased activity 3.5
polydipsia 3.5
polyuria 3.0
exhaustion 2.7
decreased appetite 2.4
hyperoxia 2.2
acute stress 2.0
hypocapnia 1.8
twitching 1.6
cachexia 1.1
acidity 1.0
fatigue 1.0
hypercapnia 0.6
agitation 0.6
hypothermia 0.5
anorexia 0.4
tremor 0.4
collapse 0.3
numbness 0.2
hunger 0.1
lethargy 0.1
hepatomegaly 0.1
flushing -0.1
anesthesia -0.1
myalgia -0.1
functional recovery -0.2
regurgitation -0.4
overweight -0.5
seizures -0.6
syncope -0.6
weakness -0.7
splenomegaly -0.7
insomnia -0.8
Ill -0.9
thinning -0.9
erythema -1.1
stigma -1.1
dyspnea -1.2
ataxia -1.4
vomiting -1.4
respiratory distress -1.7
discomfort -1.9
nausea -2.0
discomfort -2.0
headache -3.2
pain -3.9
Drug
Fructose-1,6-Diphosphate 12.6
Sodium Pentobarbital 11.0
Fructose-6-Phosphate 11.0
1,4-Dithiothreitol 9.1
Carboxyatractyloside 8.7
Iotrolan 8.1
Adenyl 7.9
Berberine chloride 7.8
Insulin glulisine 7.5
Lonafarnib 7.4
Naftidrofuryl 7.3
Cibacron Blue 7.0
1-Deoxynojirimycin 6.9
Penfluridol 6.9
Fructose 6.5
Ciglitazone 6.3
Cellulose acetate 6.1
Metrizamide 5.9
Glybenclamide 5.9
Marcaine 5.8
Icodextrin 5.8
Adenosine triphosphate 5.7
Pepstatin 5.6
Pyridoxal phosphate 5.4
Rasagiline 5.3
Fenbendazole 5.3
Pentostam 5.2
K-252a 5.1
NADH 5.1
Carbenoxolone 5.0
SMP 5.0
Thiopentone 4.9
Galactose 4.9
Gliclazide 4.7
ARA-C 4.7
Cytidine 4.7
citric acid 4.6
Thioridazine 4.6
Crystal Violet 4.6
Rasburicase 4.6
Pyridoxal 4.5
Bayer 4.5
Epoetin 4.5
Rosiglitazone 4.5
Salicylate 4.4
Clofibrate 4.4
Lactose 4.4
Epoetin alfa 4.3
Glide 4.3
Guanidine 4.2
Guanidine 4.2
Adenosine deaminase 4.1
Xylocaine 4.1
Piracetam 4.1
Wine 4.1
Rolipram 3.8
NAG 3.8
Liraglutide 3.8
Maltose 3.7
Papaverine 3.7
pyridoxal phosphate 3.6
Glucagon 3.5
TES 3.4
CDP 3.4
Helium 3.3
Serum albumin 3.3
Vitamin B 3.3
FAD 3.1
Portal 3.1
Gleevec 3.1
OTC 3.0
Amiloride 3.0
MgSO4 3.0
Glycerol 3.0
Bupivacaine 3.0
Diurnal 2.8
Leaf 2.8
Amiloride 2.7
lactose 2.7
DFP 2.7
more...
Enzyme
hexokinase 12.6
mannitol-1-phosphatase 10.9
aldose-6-phosphate reductase 10.3
glucose-1-phosphate cytidylyltransferase 10.2
EC 2.3.1.14 10.2
phosphofructokinase 10.2
fructokinase 10.1
N-acetylglucosamine kinase 10.1
HK3 10.1
glucokinase 10.0
mannokinase 9.9
pyruvate kinase 9.7
oxoglutarate dehydrogenase 9.6
L-arabinitol dehydrogenase 9.6
phosphoglucose isomerase 9.5
2,3-bisphosphoglycerate phosphatase 9.5
phosphoglyceromutase 9.5
polyphosphate glucokinase 9.5
phosphoglucomutase 9.5
ADP-dependent glucokinase 9.4
triokinase 9.4
phosphofructokinase 1 9.4
ketohexokinase 9.3
EC 2.4.1.11 9.3
6-phosphogluconate dehydrogenase 9.0
6-phosphogluconate dehydrogenase 9.0
octanol dehydrogenase 9.0
glucose-6-phosphatase 9.0
glucose-6-phosphate dehydrogenase 8.9
phosphomannose isomerase 8.9
L-rhamnulose kinase 8.9
EC 2.7.7.9 8.8
glycerol kinase 8.8
3-oxoacid CoA-transferase 8.8
PEP phosphatase 8.8
gluconate dehydrogenase 8.7
fructose 1,6-bisphosphatase 8.6
mannitol dehydrogenase 8.6
mannitol dehydrogenase 8.6
3-hydroxyacyl-CoA dehydrogenase 8.6
EC 1.1.1.47 8.6
HK2 8.5
citrate synthase 8.5
adenylate kinase 8.5
aldolase 8.5
gluconokinase 8.4
nucleoside diphosphokinase 8.4
EC 2.7.1.90 8.4
erythritol kinase 8.4
3-hydroxyacyl-CoA dehydrogenase 8.3
UDP glucosyltransferase 8.3
sucrose synthase 8.3
propionate kinase 8.2
mannitol 1-phosphate dehydrogenase 8.2
arabitol dehydrogenase 8.2
EC 1.1.1.82 8.2
EC 1.1.1.40 8.2
pyranose oxidase 8.2
trehalose 6-phosphate phosphatase 8.2
malate dehydrogenase 8.2
phosphoglycerate kinase 8.2
glucose permease 8.1
inosine kinase 8.1
6-phosphogluconolactonase 8.1
EC 1.1.1.38 8.1
N-acetylglucosamine-6-phosphate deacetylase 8.1
beta-hydroxybutyrate dehydrogenase 8.1
glycerol 3-phosphate dehydrogenase 8.1
ribulose 5-phosphate 3-epimerase 8.0
glucosamine-6-phosphate deaminase 8.0
maltose phosphorylase 8.0
acetate kinase 7.8
glycerol-3-phosphate dehydrogenase 7.8
mutarotase 7.8
phosphorylase 7.8
glutamic dehydrogenase 7.8
glycerol-3-phosphate dehydrogenase 7.7
2-keto-3-deoxy-6-phosphogluconate aldolase 7.7
pyruvate dehydrogenase phosphatase 7.7
trehalose phosphate synthase 7.7
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Compound
N-Acetylneuraminic acid 9-phosphate 12.6
C6H12S 11.6
3-Chloromethylthiochromone-1,1-dioxide 11.6
Agaricic acid 11.6
Triethyloxonium tetrafluoroborate 11.0
Pentoxyl 10.6
Echitamine 10.0
2,5-Anhydro-D-mannitol 10.0
6-Deoxy-D-glucose 9.6
Pelentan 9.6
Hymenoxon 9.4
Glucose 6-phosphate 9.3
L-Ribulose 5-phosphate 9.2
hept-2-ulose 9.1
Isopulegol 9.0
F6P 8.9
F6P 8.9
C6H12O6 8.9
glucose-6-phosphate 8.9
Diadenosine pentaphosphate 8.9
Isopulegol 8.9
Mannoheptulose 8.8
ethyl 3,4-dihydroxybenzoate 8.8
6-phosphogluconolactone 8.7
HKP 8.6
Turanose 8.5
Turanose 8.5
1H-indazole-3-carboxylic acid 8.5
Pyruvate kinase 8.4
Deoxyelephantopin 8.4
Cytochalasin A 8.2
6-phosphogluconate 8.2
fructose-1-phosphate 8.2
TREHALOSE 8.0
3-mercapto-1,2-propanediol 8.0
hexose 8.0
hexose 8.0
hexose 8.0
Ethyl Violet 7.9
hexos-2-ulose 7.9
hexos-2-ulose 7.9
mannitol-1-phosphate 7.8
Ribose 5-phosphate 7.8
Xylulose 7.7
Berberine chloride 7.7
Procion Yellow 7.6
Aminoantipyrine 7.6
hexose 7.6
2,3-diphosphoglycerate 7.5
Glyceraldehyde 7.5
C6H12O6 7.5
dihydroxyacetone-phosphate 7.5
pentose 7.4
pentose 7.4
C6H12O6 7.4
Atractyloside 7.4
Phenamil 7.4
pentose 7.4
C12H12N2 7.4
pentose 7.4
Neocuproine 7.4
D-Glyceraldehyde 7.3
Trehalose-6-phosphate 7.3
Brusatol 7.3
p-CA 7.2
Melarsoprol 7.2
fructose-6-P 7.2
D-Glyceraldehyde 7.2
Phosphorylase a 7.2
dADP 7.2
Mipafox 7.1
D-allose 7.1
dimethyl succinate 7.1
GDP-glucose 7.1
2-Deoxy-D-glucose 7.0
6-aminonicotinamide 7.0
Tetrahydrocurcumin 6.9
Digitonin 6.9
Mannose 6.8
ADP-glucose 6.8
more...