Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.1.1 (hexokinase)
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Human Gene/Protein
HKDC1 protein 12.6
hexokinase 12.6
GPR107 protein 12.6
EIF-2B 12.6
ATP:D-hexose 6-phosphotransferase 12.6
Hexokinase type I 12.4
hexokinase III 12.2
Hexokinase-2 12.2
Hexokinase 11.6
GLUT-9 11.6
hexokinase 4 11.6
G6d 11.6
hHK1 11.6
Hexokinase III 11.6
solute carrier family 2 (facilitated glucose transporter), member 3 11.6
NADH dehydrogenase (ubiquinone) Fe-S protein 2 11.6
kelch-like 12 11.6
arrestin domain containing 4 11.6
Kelch-like protein 7 11.6
hexokinase 3 11.5
HKDC1 11.2
HKII 11.1
N-Acetylglucosamine kinase 11.0
Hexokinase II 10.8
hexokinase 1 10.8
Nucleoside diphosphokinase 10.8
Kelch-like protein 12 10.6
HKI 10.5
6-phosphofructokinase 10.4
Hexokinase 1 10.4
ARRDC4 10.4
HK4 10.4
KID-1 10.4
glucose transporter 8 10.3
phosphofructokinase 10.3
ORP-1 10.2
PHLPPL 10.2
LY6/PLAUR domain containing 4 10.2
Multiple inositol polyphosphate phosphatase 10.2
phosphorylase, glycogen 10.1
more...
Disease
Hexokinase deficiency 12.6
Chronic hemolytic anemia 10.2
HPLE 10.0
CLL variants 10.0
GST6 8.8
sideroblastosis 8.7
fructosuria 8.6
trisomy 10p 8.4
metastatic papillary thyroid cancer 8.0
Type V hyperlipoproteinemia 7.9
Pyridoxine deficiency 7.8
Biotin deficiency 7.6
pyruvate kinase deficiency 7.5
Disuse atrophy 7.4
pediatric liver cancer 7.2
Glycerol kinase deficiency 7.1
MODY2 7.1
Erythroleukemia 6.9
preneoplastic state 6.9
Hers 6.9
Mitochondrial DNA depletion 6.8
nervous disorder 6.7
erythroblastopenia 6.7
recurrent thyroid cancer 6.6
hereditary nonspherocytic hemolytic anemia 6.6
Parry 6.5
BHD 6.3
lobomycosis 6.0
renal glycosuria 5.9
Lederer 5.9
BHD 5.8
congenital hemolytic anemia 5.8
diphyllobothriasis 5.8
disorders of carbohydrate metabolism 5.7
viral carcinogenesis 5.6
amebic colitis 5.6
GHD 5.5
Peritoneum 5.5
Peritoneum 5.5
Jejunum 5.4
more...
Symptom
Anoxia 5.0
asterixis 4.9
testicular pain 4.1
starvation 4.1
POA 3.5
Decreased activity 3.5
polydipsia 3.5
polyuria 3.0
exhaustion 2.7
decreased appetite 2.4
hyperoxia 2.2
acute stress 2.0
hypocapnia 1.8
twitching 1.6
cachexia 1.1
acidity 1.0
fatigue 1.0
hypercapnia 0.6
agitation 0.6
hypothermia 0.5
anorexia 0.4
tremor 0.4
collapse 0.3
numbness 0.2
hunger 0.1
lethargy 0.1
hepatomegaly 0.1
flushing -0.1
anesthesia -0.1
myalgia -0.1
functional recovery -0.2
regurgitation -0.4
overweight -0.5
seizures -0.6
syncope -0.6
weakness -0.7
splenomegaly -0.7
insomnia -0.8
Ill -0.9
thinning -0.9
more...
Drug
Fructose-1,6-Diphosphate 12.6
Sodium Pentobarbital 11.0
Fructose-6-Phosphate 11.0
1,4-Dithiothreitol 9.1
Carboxyatractyloside 8.7
Iotrolan 8.1
Adenyl 7.9
Berberine chloride 7.8
Insulin glulisine 7.5
Lonafarnib 7.4
Naftidrofuryl 7.3
Cibacron Blue 7.0
1-Deoxynojirimycin 6.9
Penfluridol 6.9
Fructose 6.5
Ciglitazone 6.3
Cellulose acetate 6.1
Metrizamide 5.9
Glybenclamide 5.9
Marcaine 5.8
Icodextrin 5.8
Adenosine triphosphate 5.7
Pepstatin 5.6
Pyridoxal phosphate 5.4
Rasagiline 5.3
Fenbendazole 5.3
Pentostam 5.2
K-252a 5.1
NADH 5.1
Carbenoxolone 5.0
SMP 5.0
Thiopentone 4.9
Galactose 4.9
Gliclazide 4.7
ARA-C 4.7
Cytidine 4.7
citric acid 4.6
Thioridazine 4.6
Crystal Violet 4.6
Rasburicase 4.6
more...
Enzyme
hexokinase 12.6
mannitol-1-phosphatase 10.9
aldose-6-phosphate reductase 10.3
EC 2.3.1.14 10.2
glucose-1-phosphate cytidylyltransferase 10.2
phosphofructokinase 10.2
fructokinase 10.1
N-acetylglucosamine kinase 10.1
HK3 10.1
glucokinase 10.0
mannokinase 9.9
pyruvate kinase 9.7
oxoglutarate dehydrogenase 9.6
L-arabinitol dehydrogenase 9.6
phosphoglucose isomerase 9.5
2,3-bisphosphoglycerate phosphatase 9.5
phosphoglyceromutase 9.5
polyphosphate glucokinase 9.5
phosphoglucomutase 9.5
ADP-dependent glucokinase 9.4
triokinase 9.4
phosphofructokinase 1 9.4
ketohexokinase 9.3
EC 2.4.1.11 9.3
6-phosphogluconate dehydrogenase 9.0
6-phosphogluconate dehydrogenase 9.0
octanol dehydrogenase 9.0
glucose-6-phosphatase 9.0
glucose-6-phosphate dehydrogenase 8.9
phosphomannose isomerase 8.9
L-rhamnulose kinase 8.9
EC 2.7.7.9 8.8
glycerol kinase 8.8
3-oxoacid CoA-transferase 8.8
PEP phosphatase 8.8
gluconate dehydrogenase 8.7
fructose 1,6-bisphosphatase 8.6
mannitol dehydrogenase 8.6
mannitol dehydrogenase 8.6
3-hydroxyacyl-CoA dehydrogenase 8.6
more...
Compound
N-Acetylneuraminic acid 9-phosphate 12.6
C6H12S 11.6
Agaricic acid 11.6
3-Chloromethylthiochromone-1,1-dioxide 11.6
Triethyloxonium tetrafluoroborate 11.0
Pentoxyl 10.6
2,5-Anhydro-D-mannitol 10.0
Echitamine 10.0
Pelentan 9.6
6-Deoxy-D-glucose 9.6
Hymenoxon 9.4
Glucose 6-phosphate 9.3
L-Ribulose 5-phosphate 9.2
hept-2-ulose 9.1
Isopulegol 9.0
F6P 8.9
F6P 8.9
C6H12O6 8.9
glucose-6-phosphate 8.9
Isopulegol 8.9
Diadenosine pentaphosphate 8.9
Mannoheptulose 8.8
ethyl 3,4-dihydroxybenzoate 8.8
6-phosphogluconolactone 8.7
HKP 8.6
1H-indazole-3-carboxylic acid 8.5
Turanose 8.5
Turanose 8.5
Pyruvate kinase 8.4
Deoxyelephantopin 8.4
Cytochalasin A 8.2
6-phosphogluconate 8.2
fructose-1-phosphate 8.2
TREHALOSE 8.0
3-mercapto-1,2-propanediol 8.0
hexose 8.0
hexose 8.0
hexose 8.0
Ethyl Violet 7.9
hexos-2-ulose 7.9
more...