Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.1.1 (hexokinase)
 5,274 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
hexokinase 5231
ATP 1110
pyruvate kinase 728
phosphofructokinase 686
insulin 643
glucose-6-phosphate dehydrogenase 515
lactate dehydrogenase 490
glucokinase 489
ADP 384
Sep 373
Mol 361
Hexokinase 282
citrate synthase 260
glucose-6-phosphatase 251
glucose transporter 207
malate dehydrogenase 203
glycolytic enzyme 172
AMP 156
ATPase 150
phosphorylating 132
creatine kinase 130
6-phosphogluconate dehydrogenase 121
NADH 118
adenylate kinase 112
glycogen phosphorylase 107
phosphoglucose isomerase 103
glyceraldehyde-3-phosphate dehydrogenase 103
phosphatase 103
glycogen synthase 93
NADPH 92
hemoglobin 90
outer mitochondrial membrane 86
fructose-1,6-bisphosphatase 84
NAD 80
NADP 79
phosphoglycerate kinase 78
Glucokinase 77
fructokinase 76
glutamate dehydrogenase 75
enolase 73
pyruvate dehydrogenase 71
phosphoenolpyruvate carboxykinase 70
GLUT1 70
HKII 67
isocitrate dehydrogenase 66
6-phosphofructokinase 65
hexokinase II 64
superoxide dismutase 61
porin 61
aspartate aminotransferase 60
catalase 59
ATP:D-hexose 6-phosphotransferase 58
CO2 57
NAD+ 56
alkaline phosphatase 56
glucosamine 55
NMR 54
cytochrome c 54
glutathione peroxidase 52
FDG 50
HKI 50
hexokinase 2 50
glutathione reductase 49
Gen 49
PHI 47
LDH 46
hexokinase 1 44
glycerol kinase 43
GLUT4 43
voltage-dependent anion channel 43
NADP+ 41
glutaminase 41
endoplasmic reticulum 40
cytochrome 40
alcohol dehydrogenase 39
GSH 39
cytochrome c oxidase 39
glucagon 38
GTP 36
GLUT-4 36
glycerol-3-phosphate dehydrogenase 35
VDAC 35
Phosphofructokinase 34
GLUT-1 34
HK1 33
HK2 33
glucose dehydrogenase 32
acid phosphatase 32
membrane-bound 32
TCA 32
PFK 32
Bcl-2 32
GLUT2 32
Hexokinase-2 31
reductase 30
peroxidase 30
alanine aminotransferase 30
VDAC1 30
epididymal 29
triosephosphate isomerase 29
AMP-activated protein kinase 28
aldose reductase 26
glyceraldehyde 3-phosphate dehydrogenase 26
mTOR 26
SDS 25
acetylcholinesterase 25
polypeptide 25
3-hydroxyacyl-CoA dehydrogenase 25
pyruvate carboxylase 25
Pyruvate kinase 25
caspase-3 24
Glucose-6-phosphate dehydrogenase 24
apyrase 24
p53 24
amylase 24
fructose 1,6-bisphosphatase 23
serum albumin 23
insulin receptor 23
sorbitol dehydrogenase 22
adenosine triphosphatase 22
Bot 21
albumin 21
microsomal 21
Hexokinase II 21
spermatozoa 21
oxidoreductase 20
esterase 20
SOD 20
calmodulin 19
ATP synthase 19
trehalase 19
ROS 19
protein kinase B 19
erythroid 19
transketolase 18
CTP 18
dimeric 18
fatty acid synthase 18
AMPK 17
GLUT3 17
fumarase 17
pyruvate dehydrogenase kinase 17
phosphatidylinositol 3-kinase 17
phosphoglycerate mutase 17
cytokine 17
PDH 17
brain) 16
G6PD 16
carnitine palmitoyltransferase 16
TNF 16
thymidine kinase 16
gut 16
protein phosphatase 15
collagen 15
IRS-1 15
PI3K 15
alpha-amylase 15
alpha-glucosidase 15
GLUT-2 15
glucose transporter 3 15
more...
Disease
cancer 343
diabetes 331
tumor 310
hyperglycemia 112
hepatocellular carcinoma 108
type 2 diabetes 58
breast cancer 51
hypoglycemia 48
GSH 41
carcinoma 40
Alzheimer's disease 39
ischemia 39
tumor growth 35
obesity 35
hyperinsulinemia 35
cold 30
glioma 29
depression 26
SDS 25
glucose intolerance 25
hemolytic anemia 23
tumor progression 19
MCF 18
leukemia 18
carcinogenesis 17
neuroblastoma 17
adenocarcinoma 16
tumorigenesis 16
Schistosoma mansoni 16
insulinoma 16
anemia 16
idiopathic thrombocytopenic purpura 15
hypertension 15
melanoma 15
colon cancer 14
SEM 14
worms 13
hyperthyroidism 13
dyslipidemia 12
dehydration 12
type 1 diabetes 12
metastases 12
hypothyroidism 12
cataract 11
mole 11
hyperlipidemia 11
mole 11
gastric cancer 10
sarcoma 10
colorectal cancer 10
lung cancer 10
fatty liver 9
Chagas 9
cystic fibrosis 9
squamous cell carcinoma 9
epididymis 9
liver cancer 9
sepsis 8
heart failure 8
cirrhosis 8
dementia 8
sepsis 8
uterus 8
chronic obstructive pulmonary disease 8
liver cancer 8
malaria 7
malnutrition 7
FAS 7
B-cell lymphoma 7
amebiasis 7
lymphoma 7
Parry 7
Parkinson's disease 6
rheumatoid arthritis 6
metabolic disorder 6
DBA 6
ovarian cancer 6
chronic lymphocytic leukemia 6
fits 6
seminal vesicles 6
chronic myeloid leukemia 6
non-small cell lung cancer 6
Blocking 6
lung carcinoma 5
coma 5
primary tumor 5
ALD 5
pH increased 5
hyperphagia 5
G6PD deficiency 5
epilepsy 5
glioblastoma 5
chronic lymphocytic leukemia 5
astrocytoma 5
multiple myeloma 5
HIV 5
aggressiveness 5
pancreatic cancer 5
retinitis pigmentosa 5
neuropathy 5
infectious diseases 5
pyruvate kinase deficiency 5
gestational diabetes mellitus 5
renal disease 5
myocardial ischemia 5
fibrosarcoma 5
Rous sarcoma 5
prostate cancer 5
myopathy 4
heart disease 4
Dissociation 4
multiple sclerosis 4
liver abscess 4
virus infection 4
Leukemia 4
cerebral ischemia 4
African trypanosomiasis 4
thalassemia 4
Testis 4
encephalopathy 4
retinoblastoma 4
thyroid cancer 4
medulloblastoma 4
Testis 4
stroke 4
SPS 4
Infection 4
Brown 4
amebic colitis 4
ventricular hypertrophy 4
SPS 4
adenoma 3
Mycobacterium 3
Hepatocellular carcinoma 3
primary biliary cirrhosis 3
pertussis 3
NAME 3
hemiparesis 3
leishmaniasis 3
liver disease 3
IVF 3
alcohol abuse 3
premenstrual syndrome 3
neoplastic transformation 3
PMS 3
Evans 3
EMT 3
lactic acidosis 3
STS 3
Ovary 3
cervical cancer 3
abortion 3
immaturity 3
ACP 3
lupus 3
Steroids 3
ATM 3
erythroblastopenia 3
encephalomyelitis 3
Hodgkin's disease 3
more...
Symptom
starvation 70
fatigue 17
anesthesia 17
exhaustion 15
seizures 9
collapse 6
acidity 5
polydipsia 4
hypothermia 4
tremor 4
weakness 4
hyperoxia 4
polyuria 4
anorexia 3
agitation 3
acute stress 3
overweight 3
Anoxia 3
pain 3
dyspnea 2
hypercapnia 2
functional recovery 2
vomiting 2
cachexia 2
insomnia 1
respiratory distress 1
nausea 1
testicular pain 1
numbness 1
hepatomegaly 1
hunger 1
Decreased activity 1
twitching 1
ataxia 1
regurgitation 1
thinning 1
POA 1
erythema 1
Ill 1
asterixis 1
lethargy 1
flushing 1
splenomegaly 1
stigma 1
syncope 1
hypocapnia 1
headache 1
discomfort 1
decreased appetite 1
myalgia 1
discomfort 1
Drug
NADH 123
citric acid 41
Fructose 28
Leaf 25
ROS 19
ascorbate 19
lactose 18
vitamin E 14
lysine 14
Cibacron Blue 10
Adenosine triphosphate 8
FAD 8
Gel 7
Cardiovasc 7
Glucagon 7
NH3 6
Metrizamide 6
Portal 6
Bayer 6
DNase I 5
Galactose 5
CaCl2 5
NAG 5
CaCl2 5
Adriamycin 5
pyridoxal phosphate 5
CSF 5
CaCl2 5
caffeine 4
Asn 4
Lactose 4
Nephron 4
CDP 4
Glutathione 4
Biopolymers 3
MAP 3
Rosiglitazone 3
Nephron 3
Alanine 3
Dermatol 3
Cellulose acetate 3
Ethanol 3
Vitamin A 3
Glycerol 3
PTH 2
Amiloride 2
Salicylate 2
Captopril 2
IL-2 2
Glide 2
Adenosine deaminase 2
ABC 2
Serum albumin 2
SMP 2
MRC 2
ALA 2
Gleevec 2
Vitamin B 2
Bifidobacterium 2
Check 2
MgSO4 2
Wine 2
Diurnal 2
Carboxyatractyloside 2
Clofibrate 2
Iotrolan 2
Naftidrofuryl 2
K-252a 2
Amiloride 2
9-THC 1
PCB 1
Imatinib 1
Growth hormone 1
Marcaine 1
Adenyl 1
Diphenhydramine 1
Fraction 1
Pyridoxal 1
Bevacizumab 1
Piracetam 1
Thioridazine 1
HCG 1
Heme 1
nitroglycerin 1
Maltose 1
Fenbendazole 1
Cetuximab 1
Pentostam 1
DMAP 1
-deoxyadenosine 1
Rasburicase 1
CTX 1
Sodium Pentobarbital 1
Ginseng 1
niacin 1
Honey 1
VCR 1
ARA-C 1
Guanidine 1
ETS 1
Dial 1
OTC 1
Carbenoxolone 1
Spectrum 1
Berberine chloride 1
Insulin glulisine 1
Parkin 1
Indomethacin 1
FeCl3 1
1-Deoxynojirimycin 1
balanced salt solution 1
OTC 1
Epoetin alfa 1
Cytidine 1
Fructose-6-Phosphate 1
Papaverine 1
Lonafarnib 1
ETA 1
Gliclazide 1
Glybenclamide 1
Capsicum 1
Ciglitazone 1
Bupivacaine 1
Pyridoxal phosphate 1
Xylocaine 1
Fructose-1,6-Diphosphate 1
Rolipram 1
Parkin 1
Growth hormone 1
Rasagiline 1
Kenyan 1
Crystal Violet 1
Liraglutide 1
Mutagen 1
TES 1
IFN-gamma 1
DFP 1
Forskolin 1
Luteinizing 1
Thiopentone 1
Helium 1
Simvastatin 1
Itraconazole 1
Guanidine 1
Tacrolimus 1
Spectrum 1
1,4-Dithiothreitol 1
Pepstatin 1
Albumin 1
CCL 1
Epoetin 1
ADR 1
Penfluridol 1
Icodextrin 1
Enzyme
hexokinase 5274
phosphofructokinase 757
pyruvate kinase 729
glucose-6-phosphate dehydrogenase 612
lactate dehydrogenase 522
glucokinase 493
citrate synthase 266
glucose-6-phosphatase 255
malate dehydrogenase 217
phosphorylase 208
phosphoglucose isomerase 207
aldolase 201
ATPase 180
phosphoglucomutase 158
creatine kinase 152
glyceraldehyde-3-phosphate dehydrogenase 152
glyceraldehyde-3-phosphate dehydrogenase 131
6-phosphogluconate dehydrogenase 124
6-phosphogluconate dehydrogenase 124
glyceraldehyde-3-phosphate dehydrogenase 116
succinate dehydrogenase 116
adenylate kinase 115
glyceraldehyde-3-phosphate dehydrogenase 110
phosphoglycerate kinase 103
glyceraldehyde-3-phosphate dehydrogenase 103
invertase 95
pyruvate dehydrogenase 87
phosphoenolpyruvate carboxykinase 87
phosphoenolpyruvate carboxykinase 83
phosphoenolpyruvate carboxykinase 83
protein kinase 80
glutamate dehydrogenase 79
glutamate dehydrogenase 79
glutamate dehydrogenase 79
glucose oxidase 77
aspartate aminotransferase 75
enolase 75
isocitrate dehydrogenase 73
isocitrate dehydrogenase 73
pyruvate dehydrogenase 72
pyruvate dehydrogenase 71
superoxide dismutase 69
fructokinase 68
glycerol-3-phosphate dehydrogenase 66
glycerol-3-phosphate dehydrogenase 64
catalase 64
alkaline phosphatase 56
cytochrome oxidase 54
glycerol kinase 53
glutathione peroxidase 53
fructose 1,6-bisphosphatase 52
alanine aminotransferase 52
glutathione reductase 50
alcohol dehydrogenase 44
3-hydroxyacyl-CoA dehydrogenase 43
AMP-activated protein kinase 43
glutaminase 43
alpha-ketoglutarate dehydrogenase 42
peroxidase 40
diaphorase 40
PGM 40
sucrose synthase 40
alpha-glucosidase 36
3-hydroxyacyl-CoA dehydrogenase 36
histidine kinase 33
acetylcholinesterase 33
HK2 33
acid phosphatase 32
glucose dehydrogenase 32
trypsin 31
CPR 29
phosphomannose isomerase 28
ATP synthase 28
pyruvate carboxylase 27
aldose reductase 26
apyrase 26
mitogen-activated protein kinase 25
calcineurin 25
sorbitol dehydrogenase 24
luciferase 23
AMPK 23
succinic dehydrogenase 23
phosphoglyceromutase 23
protein kinase C 21
CPT 21
fumarase 21
oxoglutarate dehydrogenase 21
trehalase 19
PDK1 19
complex I 19
acyl-CoA dehydrogenase 18
acetate kinase 18
transketolase 18
phosphatidylinositol 3-kinase 17
lactic acid dehydrogenase 17
AMPK 17
beta-hydroxybutyrate dehydrogenase 17
gamma-glutamyl transpeptidase 16
ERK 16
thymidine kinase 16
focal adhesion kinase 16
alpha-amylase 15
acetyl-CoA carboxylase 15
PDH 15
ACE 15
caspase-3 15
collagenase 14
acyl-CoA dehydrogenase 14
adenosine deaminase 14
phosphoenolpyruvate carboxylase 14
phosphofructokinase 1 13
lipase 13
adenosine deaminase 13
NADPH-diaphorase 13
aconitase 13
glutamine synthetase 13
sucrase 12
mannitol dehydrogenase 12
beta-galactosidase 12
pyruvate decarboxylase 12
diaphorase 12
glutathione S-transferase 12
6-phosphofructo-2-kinase 11
chymotrypsin 11
aldehyde dehydrogenase 11
ketohexokinase 11
GSK 11
lysozyme 11
ACS 10
MDH 10
EC 1.1.1.40 10
MDH 10
MTD 10
cholinesterase 10
mannitol dehydrogenase 10
isocitrate lyase 9
aldehyde dehydrogenase 9
lipoprotein lipase 9
xanthine oxidase 9
EC 2.7.7.9 9
galactokinase 9
reverse transcriptase 9
aldehyde dehydrogenase 9
glycerol 3-phosphate dehydrogenase 9
aldehyde dehydrogenase 9
nucleoside diphosphokinase 9
firefly luciferase 9
phosphodiesterase 9
aldehyde dehydrogenase 9
NQO1 9
SPS 9
monoamine oxidase 9
urease 9
glutamic dehydrogenase 8
RNase 8
urease 8
AMP deaminase 8
NADPH oxidase 8
adenylate cyclase 8
AST 8
more...
Compound
glucose 3092
ATP 1111
phosphate 953
galactose 421
ADP 409
ADP 384
ADP 384
Dec 376
oxygen 308
hexose 282
glucose-6-phosphate 276
hexose 249
hexose 249
hexose 249
Clin 203
pentose 183
pentose 179
pentose 179
pentose 179
water 169
AMP 166
DNA 147
sodium 145
calcium 144
NAD 136
NADH 122
NADP 122
glutamate 106
glycerol 104
acetate 98
CoA 98
NADPH 94
NADPH 92
Mg2+ 86
NAD 80
glutamine 77
ethanol 75
alanine 72
CO2 72
Insulin 72
nitrogen 64
hydrogen 62
alloxan 58
sulfate 57
Lactate 55
UTP 48
urea 47
DEAE 47
2-oxoglutarate 46
salt 45
GSH 44
GSH 44
cAMP 43
ammonium 43
Sucrose 43
GlcNAc 42
nicotinamide 42
potassium 41
Glycogen 41
cysteine 41
alcohol dehydrogenase 40
ammonia 40
2,3-diphosphoglycerate 40
Glucose 6-phosphate 39
xylose 37
GTP 36
TCA 36
phosphocreatine 34
adenylate 33
tyrosine 32
acetyl-CoA 32
cyanide 31
SDS 30
leucine 30
UDP 30
Fructose 29
serine 29
UDP-glucose 28
arginine 26
6-phosphogluconate 25
Pyruvate kinase 25
lysine 25
zinc 24
methionine 24
phosphorus 24
Triton X-100 24
fluorine 24
DPG 23
uridine 23
iron 23
tryptophan 22
DPG 22
tryptophan 22
tryptophan 21
H2O2 21
copper 21
tryptophan 21
Flux 21
creatinine 21
STZ 20
pyridine 20
NH2 20
nitrate 20
manganese 20
PEG 20
isocitrate 19
GAL 19
EDTA 19
MgCl2 19
cadmium 18
CTP 18
GAP 18
EDTA 18
D-glucosamine 17
His 17
threonine 17
Asp 17
aluminum 17
MDA 17
Mannose 17
TNF 16
bromide 16
PDH 16
nitric oxide 16
ITP 15
Cardiol 15
Diabetol 15
MTT 15
Pyruvate 14
pyrimidine 14
Phe 14
ABA 14
pyrimidine 14
acrylamide 13
Tris 13
GSSG 13
Starch 13
succinic acid 12
PEG 12
GDP 12
ABA 12
Tris 12
salicylic acid 11
phosphoric acid 11
fructose-6-P 11
PEP 11
acetic acid 11
palmitoyl-CoA 10
Glucosamine 10
Dexamethasone 10
Trehalose 9
chromium 9
DBA 9
fructose-1-phosphate 9
APAP 9
aldehyde 9
PNP 9
Gly 9
Glutamate 9
PPi 9
more...