Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: EC:2.7.1.1 (
hexokinase
)
5,274
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The structure of the gene for the Type III isozyme of human
hexokinase
is nearly identical to that of previously characterized genes for other isozymes of
hexokinase
. The most striking difference is that the 5'-untranslated sequence and the initial coding sequence are contained in two exons in the Type III
hexokinase
gene but in a single exon in genes for the other isozymes. Sequence at the transcriptional start site for rat Type III
hexokinase
(S. Sebastian, J. A. White, and J. E. Wilson, 1999, J. Biol. Chem. 274, 31700-31706) is conserved in the human gene, as is an
Oct-1
site, in reverse orientation, approximately 30 bp upstream from the start site. This site has been shown to regulate transcription of both human and rat genes for Type III
hexokinase
. Comparison of the genes for the various mammalian isozymes of
hexokinase
indicates that a major feature in the evolution of this isozyme family has been acquisition of alternative first exons.
...
PMID:The human gene for the type III isozyme of hexokinase: structure, basal promoter, and evolution. 1167 72
