Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: EC:2.7.1.1 (hexokinase)
 5,274 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In previous papers we reported that the earlier peak time (PT) in radiorespiratory during feeding with 3'-methyl-4-(dimethylamino)azobenzene(3'-Me-DAB) is due to activation of the hexose monophosphate (HMP) pathway together with hepatic cell proliferation reflecting the toxic effects of this carcinogen. In this study, we investigated the correlation between the results of radiorespiratory and the levels of enzyme activities of HMP pathway in regenerating rat liver in connection with hepatic cell proliferation. [3H]Thymidine incorporation into rat liver DNA and the activities of hexokinase (HK) and glucose-6-phosphate dehydrogenase(G-6-PD) reached a maximum at the 3rd day after partial hepatectomy. On radiorespirometry using [U-14C] glucose, the peak time (PT) was much earlier at the 2nd to 3rd day after partial hepatectomy. The peak height (PH) decreased to less than 1/2 of the initial level at the 2nd, but began to recover from the 3rd day. The yield value (YV) remained below the initial level for 4 days after the operation.
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PMID:Radiorespirometric analysis of glucose metabolism in the rat during feeding with 3'-methyl-4-(dimethylamino)azobenzene--radiorespirometry after partial hepatectomy. 12 May 61

The methods for proof and determination of urinary glucose practiced in the GDR are discussed and in a comparative determination confronted to the hexokinase method (Glucoquant). Apart from this the Biophan-G stripe was compared with the multi-test stripes Ecur-test (Boehringer) and N-multistix (Ames). The methods of urinary glucose which are declared as obligatory for the GDR in the DAB 7 (D. L.) do no more correspond to the present level of knowledge. The Biophan-G stripe is the exception. By means of Ecur-test and N-multistix an in every case a 98 per cent correct semiquantitative evaluation was obtained in 250 different urines, in the Biophan-G stripe a 94 per cent evaluation.
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PMID:[Development of methods for the qualitative and quantitative determination of urinary glucose]. 734 11